BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?
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Purpose of Review
The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.
Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions.
Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests.
KeywordsBasophil activation test BAT Hypersensitivity reactions Drug allergy
Statement of Contribution
All authors meet the three conditions:
(1) Substantial contributions to conception of the study
(2) Drafting the article and revising it critically for important intellectual content
(3) Final approval of the version to be published
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflicts of interest relevant to this manuscript.
I confirm that this paper has been read and approved by all the co-authors, and that no conflicts of interest exist regarding its publication.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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