New and Potential Treatments for Atopic Dermatitis: Biologicals and Small Molecules

  • Mario Sánchez-BorgesEmail author
  • Arnaldo Capriles-Hulett
  • Jose Antonio Ortega-Martell
  • Ignacio Ansotegui Zubeldia
Allergic Skin Diseases (Luz Fonacier and Andreas Wollenberg, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Allergic Skin Diseases


Purpose of Review

An update on new therapies currently approved or potentially useful in the future for the management of patients suffering moderate-to-severe atopic dermatitis.

Recent Findings

New pathogenic mechanisms involved in atopic dermatitis have permitted to propose novel therapeutic approaches devised to control the inflammatory process observed in involved cutaneous tissues by neutralizing mediators, cytokines, and their receptors.


Recent research findings have disclosed important and previously unrecognized pathogenic mechanisms that have resulted in innovative targeted therapies, such as dupilumab, and potentially other biologicals and small molecules. Further studies should permit the sub-classification of patients according to the relevance of different mediators and inflammatory cells. It can be concluded that the treatment of atopic dermatitis has entered into the era of personalized/precision medicine.


Atopic dermatitis Biologicals Dupilumab Eczema Small molecules Treatment 



Investigator Global Assessment


Eczema Area and Severity Index


Thymus stromal lymphopoietin


Innate lymphoid cell


Scoring of Atopic Dermatitis



Investigator’s funds.

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Mario Sánchez-Borges
    • 1
    • 2
    Email author
  • Arnaldo Capriles-Hulett
    • 1
  • Jose Antonio Ortega-Martell
    • 3
  • Ignacio Ansotegui Zubeldia
    • 4
  1. 1.Allergy and Clinical Immunology DepartmentCentro Médico Docente La TrinidadCaracasVenezuela
  2. 2.Clínica El AvilaCaracasVenezuela
  3. 3.School of MedicineAutonomous University of Hidalgo StatePachucaMexico
  4. 4.Department of Allergy and ImmunologyHospital QuironsaludBilbaoSpain

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