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Next-Generation Approaches for the Treatment of Food Allergy

  • Immunotherapy and Immunomodulators (Brian Vickery, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

IgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance.

Recent Findings

Oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) will likely be integrated into clinical practice as part of food allergy management in the near future. Newer approaches, such as sublingual immunotherapy (SLIT), modified proteins, lysosomal-associated membrane protein DNA (LAMP DNA) vaccines, and the use of immunomodulatory agents, are early in development and depending on results, could also become important treatment options.

Summary

This is a review of novel approaches to the treatment of food allergy that are currently under investigation, including the use of SLIT, modified proteins, probiotics, Chinese herbal supplements, biologic therapies, and DNA vaccines, as well as a summary of the current status of OIT and EPIT.

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  1. Division of Pediatric Allergy and Immunology, Department of Pediatrics, John Hopkins University School of Medicine, 600 N. Wolfe St., CMSC 1102, Baltimore, MD, 21287, USA

    Jennifer A. Dantzer & Robert A. Wood

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  1. Jennifer A. Dantzer
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Dr. Dantzer reports grants from NIH, grants from Aimmune, and personal fees from Maryland Chapter of the American Academy of Pediatrics, outside the submitted work; Dr. Wood reports grants from NIH, from Aimmune, from Astellas, from DBV, from Sanofi, from regeneron, and other from Up To Date, outside the submitted work.

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Dantzer, J.A., Wood, R.A. Next-Generation Approaches for the Treatment of Food Allergy. Curr Allergy Asthma Rep 19, 5 (2019). https://doi.org/10.1007/s11882-019-0839-5

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