The Multifaceted B Cell Response in Allergen Immunotherapy
While allergen immunotherapy (AIT) for IgE-mediated diseases holds curative potential, the considerable heterogeneity in clinical outcomes may relate to the complex mechanisms of tolerance. The regulation of humoral immunity by AIT contributes to the suppression of allergic responses. Recent findings have revealed novel roles for IgA and IgG antibodies in the induction of tolerance. These mechanisms synergize with their ability to block allergen-IgE binding and mediate inhibitory signaling of effector cells of the allergic response. In addition, the regulatory activity of B cells in AIT extends beyond IL-10 secretion and induction of IgG4. Here, we review the evolution of the B cell response during AIT with special emphasis on the novel protective mechanisms entailing humoral immunity.
KeywordsB cell immunity Allergen immunotherapy Blocking IgG antibodies IgA response B regulatory cells Allergy
We thank Dr. Bert Ruiter, Dr. Oscar Palomares, and Mr. Yosef Ellenbogen for critical review of the manuscript. Dr. Jiménez-Saiz is a Juan de La cierva – Incorporación scholar granted by the Spanish Ministry of Economy and Competitivity. Dr. Patil is a Principal Investigator at the Center for Inflammatory and Immunological Diseases at Massachusetts General Hospital and Harvard Medical School and is supported by the National Institutes of Health K23AI121491 grant from National Institutes of Allergy and Infectious Diseases.
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Conflict of Interest
Drs. Jiménez-Saiz and Patil declare no conflict of interest. Dr. Patil reports grants from National Institutes of Health, National Institutes of Allergy and Infectious Diseases.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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