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Prospects for Monoclonal Antibody Therapy in Pediatric Asthma

  • August Generoso
  • Christine Muglia-Chopra
  • John Oppenheimer
Pediatric Allergy and Immunology (W Dolen, Section Editor)
  • 240 Downloads
Part of the following topical collections:
  1. Topical Collection on Pediatric Allergy and Immunology

Abstract

Purpose of Review

The profile of biologic therapies for asthma is growing rapidly. We discuss how to match the proper pediatric patient with the most effective therapy.

Recent Findings

Currently available biologic therapies are most effective in patients with T2 high asthma. Newer drugs are currently being studied which target TSLP and interleukin 33. These newer drugs may provide options for asthmatics who do not respond to the current anti-IgE, anti-IL5, and anti-IL4/13 therapies.

Summary

Asthma is a heterogeneous disease which can be driven by different inflammatory mediators in different patients. To select the most effective biologic therapy for a pediatric patient, the asthma phenotype must first be determined. The steep cost of biologics limits their use, which makes proper pairing of patient to therapy even more crucial. Presently, several therapies exist for T2 high asthma, but it is hoped in the future that development of drugs effective for T2 low asthmatics will be available as well.

Keywords

Asthma Children Pediatrics Biologic therapy T2 high 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • August Generoso
    • 1
  • Christine Muglia-Chopra
    • 1
  • John Oppenheimer
    • 1
  1. 1.Rutgers New Jersey Medical SchoolThe State University of New JerseyNewarkUSA

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