Nanotechnologies for In Vitro IgE Testing
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Purpose of Review
This review discusses the recent advances in the development of IgE antibody assays based on nanotechnologies. IgE blood testing is an important part of the diagnostic workup of IgE-mediated hypersentivity. We also address the challenges in moving from an academic proof-of-concept to a product routinely used by allergy experts.
Several nanotechnologies have been applied to the field of IgE testing: nanoparticles are used either as a support to capture analytes or as a detection tool to enhance the measurement signal. Nanofluidics allows to reduce assay time by enhancing molecular interaction.
Nanotechnologies bring forth new methods for in vitro IgE testing. Substantial advantages such as lower sample volume, shorter assay time, simplified procedures, and lower analytic sensitivity, without affecting test precision and accuracy, can be achieved thanks to nanotechnologies.
KeywordsIgE blood test Allergy diagnosis Nanotechnology Nanofluidics Nanoparticles
Compliance with Ethical Standards
Conflict of Interest
The first author has a patented nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods issued; a patented apparatus and method for detecting and measuring biomolecular interactions; and is one of the inventors of the nanofluidic technology described in the text.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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