Rhinoviruses and Their Receptors: Implications for Allergic Disease

  • Yury A. BochkovEmail author
  • James E. Gern
Allergens (RK Bush and JA Woodfolk, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Allergens


Human rhinoviruses (RVs) are picornaviruses that can cause a variety of illnesses including the common cold, lower respiratory tract illnesses such as bronchitis and pneumonia, and exacerbations of asthma. RVs are classified into three species, RV-A, B, and C, which include over 160 types. They utilize three major types of cellular membrane glycoproteins to gain entry into the host cell: intercellular adhesion molecule 1 (ICAM-1) (the majority of RV-A and all RV-B), low-density lipoprotein receptor (LDLR) family members (12 RV-A types), and cadherin-related family member 3 (CDHR3) (RV-C). CDHR3 is a member of cadherin superfamily of transmembrane proteins with yet unknown biological function, and there is relatively little information available about the mechanisms of RV-C interaction with CDHR3. A coding single nucleotide polymorphism (rs6967330) in CDHR3 could promote RV-C infections and illnesses in infancy, which could in turn adversely affect the developing lung to increase the risk of asthma. Further studies are needed to determine how RV infections contribute to pathogenesis of asthma and to develop the optimal treatment approach to control asthma exacerbations.


Human rhinovirus Cellular receptor ICAM-1 LDLR CDHR3 Asthma Allergy 



This work was supported by the following NIH grants: UM1 AI114271, U19 AI104317, and P01 HL070831.

Compliance with Ethical Standards

Conflict of Interest

Dr. Bochkov declares no conflict of interest. Dr. Gern has served as a consultant to PREP Biopharm Inc., Janssen, and Regeneron and has received a lecture honorarium from Boehringer Ingelheim.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of PediatricsSchool of Medicine and Public Health, University of Wisconsin-MadisonMadisonUSA
  2. 2.Department of MedicineSchool of Medicine and Public Health, University of Wisconsin-MadisonMadisonUSA

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