T Regulatory Cell Biology in Health and Disease
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Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3 (FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host-commensal flora interaction, and facilitating tissue repair. Their deficiency and/or dysfunction trigger unbridled autoimmunity and inflammation. A growing number of monogenic defects have been recognized that adversely impact Treg cell development, differentiation, and/or function, leading to heritable diseases of immune dysregulation and autoimmunity. In this article, we review recent insights into Treg cell biology and function, with particular attention to lessons learned from newly recognized clinical disorders of Treg cell deficiency.
KeywordRegulatory T (Treg) cell T conventional cell (Tconv) Immune dysregulation Autoimmunity IPEX IPEX like
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Conflict of Interest
Talal Chatila and Fayhan Alroqi declare that they have no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by the authors.
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