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Immune-Microbiota Interactions: Dysbiosis as a Global Health Issue

  • Alan C. Logan
  • Felice N. Jacka
  • Susan L. PrescottEmail author
Immune Deficiency and Dysregulation (DP Houston and C Kuo, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Immune Deficiency and Dysregulation

Abstract

Throughout evolution, microbial genes and metabolites have become integral to virtually all aspects of host physiology, metabolism and even behaviour. New technologies are revealing sophisticated ways in which microbial communities interface with the immune system, and how modern environmental changes may be contributing to the rapid rise of inflammatory noncommunicable diseases (NCDs) through declining biodiversity. The implications of the microbiome extend to virtually every branch of medicine, biopsychosocial and environmental sciences. Similarly, the impact of changes at the immune-microbiota interface are directly relevant to broader discussions concerning rapid urbanization, antibiotics, agricultural practices, environmental pollutants, highly processed foods/beverages and socioeconomic disparities—all implicated in the NCD pandemic. Here, we make the argument that dysbiosis (life in distress) is ongoing at a micro- and macro-scale and that as a central conduit of health and disease, the immune system and its interface with microbiota is a critical target in overcoming the health challenges of the twenty-first century.

Keywords

Microbiome Immune development Allergic disease Obesity Neurodevelopment Probiotics Early-life nutrition Pregnancy 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Prescott declares that she is in the Scientific Advisory Boards of Danone and the Nestle Nutrition Institute. Dr. Logan declares consulting fees from Genuine Health. Dr. Jacka reports no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Alan C. Logan
    • 1
    • 4
  • Felice N. Jacka
    • 1
    • 2
    • 4
  • Susan L. Prescott
    • 1
    • 3
    Email author
  1. 1.International Inflammation Network (in-FLAME) of the World Universities NetworkPerthAustralia
  2. 2.School of MedicineDeakin UniversityMelbourneAustralia
  3. 3.School of Paediatrics and Child Health, Perth Children’s HospitalUniversity of Western AustraliaPerthAustralia
  4. 4.International Society for Nutritional Psychiatry ResearchMelbourneAustralia

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