Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

  • Saman Sabounchi
  • Jenna Bollyky
  • Kari Nadeau
Food Allergy (T Green, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Food Allergy


There has been significant increase in the prevalence of atopy over the past decade that cannot be explained by genetic predisposition. Environmental factors including nutrition, the uterine environment, and lifestyle factors are known to play a role in gene expression through epigenetic modifications. In this article, we review the literature on the environmental impact on epigenetic modulation of atopic diseases including asthma, food allergy, eczema, and allergic rhinitis. Recent public release of epigenomic data for hundreds of human tissues provides a powerful resource for further investigation of the molecular basis of atopic diseases.


Epigenetics Atopy Environmental factors Food allergy Nutrition Uterine life 


Compliance with Ethics Guidelines

Conflict of Interest

Saman Sabounchi, Jenna Bollyky, and Kari Nadeau declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Pediatrics, Division of Allergy, Immunology, and RheumatologyStanford University School of MedicineStanfordUSA

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