IgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review

  • Albert Wu
  • Nicholas H Andrew
  • Alan A McNab
  • Dinesh Selva
Autoimmunity (TK Tarrant, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Autoimmunity


In recent years, IgG4-related ophthalmic disease (IgG4-ROD) has emerged as a common cause of orbital inflammation, accounting for a substantial proportion of idiopathic orbital inflammation and lymphoid hyperplasia. The last pooled analysis of published cases was conducted in 2012, but a large number of new cases have been added to the literature since then. In this review, we present the demographic, clinical, histological, and treatment data for 172 published cases of biopsy-confirmed IgG4-ROD. Results are accompanied by a review of the relevant literature.


Immunoglobulin G4 Orbital Orbit Ocular Dacryoadenitis Lacrimal 


Compliance with Ethics Guidelines

Conflict of Interest

Albert Wu, Nicholas H. Andrew, Alan A. McNab, and Dinesh Selva declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Albert Wu
    • 1
  • Nicholas H Andrew
    • 1
  • Alan A McNab
    • 2
  • Dinesh Selva
    • 1
  1. 1.South Australian Institute of OphthalmologyUniversity of AdelaideAdelaideAustralia
  2. 2.Centre for Eye Research AustraliaUniversity of MelbourneMelbourneAustralia

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