Recombinant Allergens for Diagnosis of Cockroach Allergy

  • L. Karla Arruda
  • Michelle C. R. Barbosa
  • Ana Beatriz R. Santos
  • Adriana S. Moreno
  • Martin D. Chapman
  • Anna Pomés
ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS)
Part of the following topical collections:
  1. Topical Collection on Allergens

Abstract

Molecular cloning of cockroach allergens and their expression as recombinant proteins have allowed a better understanding of the mechanisms of cockroach allergic disease. Recombinant cockroach allergens have been used for skin testing or in vitro methods to measure IgE antibody levels in serum. Early studies evaluating selected U.S. patients revealed that a cocktail of four cockroach allergens, Bla g 1, Bla g 2, Bla g 4, and Bla g 5, would identify 95 % of cockroach allergic patients. More recent studies pointed to an important role of sensitization to tropomyosin among certain populations, and suggested that a cocktail of five allergens Bla g 1 and/or Per a 1, Bla g 2, Bla g 4, Bla g 5, and Bla g 7, and/or Per a 7, would be expected to diagnose 50– 64 % of cockroach-allergic patients worldwide. Variation in IgE reactivity profiles could be in part due to IgE responses to cross-reactive homologous allergens from different origins. The availability of purified natural or recombinant cockroach allergens provides the capacity to improve diagnosis of cockroach allergy and to develop novel forms of immunotherapy for cockroach-allergic patients.

Keywords

Cockroach Allergy Asthma IgE Skin testing Allergy diagnosis Recombinant allergens Molecular cloning Allergen structure Tropomyosin Allergen cross-reactivity 

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Bernton H, Brown H. Insect allergy—Preliminary studies of the cockroach. J Allergy. 1964;35:506–13.PubMedGoogle Scholar
  2. 2.
    Kang B, Vellody D, Homburger H, Younginger JW. Cockroach as a cause of allergic asthma. Its specificity and immunologic profile. J Allergy Clin Immunol. 1979;63:80–6.PubMedGoogle Scholar
  3. 3.••
    Barbosa MC, Santos AB, Ferriani VP, Pomés A, Chapman MD, Arruda LK. Efficacy of recombinant allergens for diagnosis of cockroach allergy in patients with asthma and/or rhinitis. Int Arch Allergy Immunol. 2013;161:213–9. This is the first study using recombinant cockroach allergens for skin testing in patients with asthma and/or rhinitis living in Brazil. The results revealed that skin testing with recombinant allergens was safe and that cockroach tropomyosin (Per a 7 allergen) was the major sensitizing allergen. By contrast, studies carried out in the United States revealed low levels of sensitization to Per a 7, and more frequent reactions to Bla g 2 and Bla g 5 among cockroach-allergic patients.PubMedGoogle Scholar
  4. 4.
    Michel S, Yawalkar N, Schnyder B, Fischer B, Helbling A. Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. J Investig Allergol Clin Immunol. 2009;19:173–9.PubMedGoogle Scholar
  5. 5.
    Arruda LK, Pomés A. Every Cockroach Is Beautiful to Its Mother. Int Arch Allergy Immunol. 2013;161:289–92.PubMedGoogle Scholar
  6. 6.
    Cornwell PB. The Cockroach, vol. 1. London: Hutchinson; 1968.Google Scholar
  7. 7.
    Sookrung N, Chaicumpa W. A revisit to cockroach allergens. Asian Pac J Allergy Immunol. 2010;28:95–106.PubMedGoogle Scholar
  8. 8.
    Arruda LK, Vailes LD, Ferriani VP, Santos AB, Pomés A, Chapman MD. Cockroach allergens and asthma. J Allergy Clin Immunol. 2001;107:419–28.PubMedGoogle Scholar
  9. 9.
    Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997;336:1356–63.PubMedGoogle Scholar
  10. 10.
    Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, et al. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998;102:563–70.PubMedGoogle Scholar
  11. 11.
    Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, et al. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. J Allergy Clin Immunol. 2003;112:87–92.PubMedGoogle Scholar
  12. 12.
    Sheehan WJ, Rangsithienchai PA, Wood RA, Rivard D, Chinratanapisit S, Perzanowski MS, et al. Pest and allergen exposure and abatement in inner-city asthma: a work group report of the American Academy of Allergy, Asthma & Immunology Indoor Allergy/Air Pollution Committee. J Allergy Clin Immunol. 2010;125:575–8.PubMedCentralPubMedGoogle Scholar
  13. 13.
    Perzanowsky MS, Platts-Mills TAE. Further confirmation of the relevance of cockroach and dust mite sensitization to inner-city asthma morbidity. Clin Exp Allergy. 2009;39:1291–3.Google Scholar
  14. 14.
    Salo PM, Arbes Jr SJ, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol. 2008;121:678–84.PubMedCentralPubMedGoogle Scholar
  15. 15.
    Sarinho E, Schor D, Veloso MA, Rizzo JA. There are more asthmatics in homes with high cockroach infestation. Braz J Med Biol Res. 2004;37:503–10.PubMedGoogle Scholar
  16. 16.
    Finn PW, Boudreau JO, He H, Wang Y, Chapman MD, Vincent C, et al. Children at risk for asthma: home allergen levels, lymphocyte proliferation, and wheeze. J Allergy Clin Immunol. 2000;105:933–42.PubMedGoogle Scholar
  17. 17.
    Silva JM, Camara AA, Tobias KR, Macedo IS, Cardoso MR, Arruda E, et al. A prospective study of wheezing in young children: the independent effects of cockroach exposure, breast-feeding and allergic sensitization. Pediatr Allergy Immunol. 2005;16:393–401.PubMedGoogle Scholar
  18. 18.
    Ramsey CD, Celedon JC, Sredl DL, Weiss ST, Cloutier MM. Predictors of disease severity in children with asthma in Hartford, Connecticut. Pediatr Pulmonol. 2005;39:268–75.PubMedGoogle Scholar
  19. 19.
    Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts-Mills TA. Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools. Thorax. 1999;54:675–80.PubMedCentralPubMedGoogle Scholar
  20. 20.
    Wang J, Visness CM, Calatroni A, Gergen PJ, Mitchell HE, Sampson HA. Effect of environmental allergen sensitization on asthma morbidity in inner-city asthmatic children. Clin Exp Allergy. 2009;39:1381–9.PubMedGoogle Scholar
  21. 21.••
    Perzanowski MS, Chew GL, Divjan A, Jung KH, Ridder R, Tang D, et al. Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. J Allergy Clin Immunol. 2013;131:886–93. This is a very interesting study which showed that prenatal exposure to cockroach allergen among Dominican and African-American pregnant women in New York was associated with a greater risk of allergic sensitization at the ages of 5–7 years. This risk was increased only among children who were also exposed to nonvolatile polycyclic aromatic hydrocarbons (PAHs), with children null for the Glutathione-S-transferase μ 1 (GSTM1) mutation being particularly vulnerable. The study highlights the fact that combustion byproducts can act as adjuvants in the development of cockroach sensitization in urban environments.PubMedCentralPubMedGoogle Scholar
  22. 22.••
    Wang J, Calatroni A, Visness CM, Sampson HA. Correlation of specific IgE to shrimp with cockroach and dust mite exposure and sensitization in an inner-city population. J Allergy Clin Immunol. 2011;128:834–7. In this study, the authors report an interesting observation, that increasing exposure to cockroach allergen in the home is associated not only with increasing in IgE to cockroach but also with increasing in IgE to shrimp. This could be due to cross-reactive IgE responses to shared allergens, including tropomyosin.PubMedCentralPubMedGoogle Scholar
  23. 23.
    Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011;364:1005–15.PubMedCentralPubMedGoogle Scholar
  24. 24.
    Pomés A, Wünschmann S, Hindley J, Vailes LD, Chapman MD. Cockroach allergens: function, structure and allergenicity. Protein Pept Lett. 2007;14:960–9.PubMedGoogle Scholar
  25. 25.
    Arruda LK, Vailes LD, Mann BJ, Shannon J, Fox JW, Vedvick TS, et al. Molecular cloning of a major cockroach (Blattella germanica) allergen, Bla g 2. Sequence homology to the aspartic proteases. J Biol Chem. 1995;270:19563–8.PubMedGoogle Scholar
  26. 26.
    Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wlodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol. 2005;348:433–44.PubMedGoogle Scholar
  27. 27.
    Tan YW, Chan SL, Ong TC, Yit le Y, Tiong YS, Chew FT, et al. Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes. J Biol Chem. 2009;284:3148–57.PubMedGoogle Scholar
  28. 28.
    Khantisitthiporn O, Sookrung N, Tungtrongchitr A, Tongtawe P, Bunnag C, Srimanote P, et al. Native troponin-T of the American cockroach (CR), Periplaneta americana, binds to IgE in sera of CR allergic Thais. Asian Pac J Allergy Immunol. 2007;25:189–97.PubMedGoogle Scholar
  29. 29.
    Chuang JG, Su SN, Chiang BL, Lee HJ, Chow LP. Proteome mining for novel IgE-binding proteins from the German cockroach (Blattella germanica) and allergen profiling of patients. Proteomics. 2010;10:3854–67.PubMedGoogle Scholar
  30. 30.•
    Jeong KY, Kim CR, Park J, Han IS, Park JW, Yong TS. Identification of novel allergenic components from German cockroach fecal extract by a proteomic approach. Int Arch Allergy Immunol. 2013;161:315–24. In this study from Korea, Jeong et al. have have found that some of 12 IgE-binding proteins identified by proteomics strategy were digestive enzymes, including α-amylase, midgut carboxypeptidase A, chymotrypsin, astacin-like metalloprotease, and trypsin. α-Amylase was found to be an important allergen with a 41 % prevalence of IgE reactivity. Amylase activity was previously reported from various cockroach gut compartments and salivary glands.The results raise the interesting possibility that α-amylase could be another invertebrate cross-reactive allergen in the cockroach, in addition to tropomyosin, glutathione S-transferase, arginine kinase. and myosin light chain, which share homologs in mites, shrimp. and parasites.PubMedGoogle Scholar
  31. 31.
    Helm R, Cockrell G, Stanley JS, Brenner RJ, Burks W, Bannon GA. Isolation and characterization of a clone encoding a major allergen (Bla g Bd90K) involved in IgE-mediated cockroach hypersensitivity. J Allergy Clin Immunol. 1996;98:172–80.PubMedGoogle Scholar
  32. 32.
    Pomés A, Melén E, Vailes LD, Retief JD, Arruda LK, Chapman MD. Novel allergen structures with tandem amino acid repeats derived from German and American cockroach. J Biol Chem. 1998;273:30801–7.PubMedGoogle Scholar
  33. 33.
    Wu CH, Wang NM, Lee MF, Kao CY, Luo SF. Cloning of the American cockroach Cr-PII allergens: evidence for the existence of cross-reactive allergens between species. J Allergy Clin Immunol. 1998;101:832–40.PubMedGoogle Scholar
  34. 34.
    Melén E, Pomés A, Vailes LD, Arruda LK, Chapman MD. Molecular cloning of Per a 1 and definition of the cross-reactive Group 1 cockroach allergens. J Allergy Clin Immunol. 1999;103:859–64.PubMedGoogle Scholar
  35. 35.
    Yang CY, Wu JD, Wu CH. Sequence analysis of the first complete cDNA clone encoding an American cockroach Per a 1 allergen. Biochim Biophys Acta. 2000;1517:153–8.PubMedGoogle Scholar
  36. 36.••
    Mueller GA, Pedersen LC, Lih FB, Glesner J, Moon AF, Chapman MD, et al. The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment. J Allergy Clin Immunol. 2013. doi:10.1016/j.jaci.2013.06.014. This very recent study revealed that the Bla g 1 allergen has a novel fold with a capacity to bind various lipids, which suggests a digestive function associated with nonspecific transport of lipid molecules in cockroaches. Characterizing the basic structural unit of Bla g 1 allowed for absolute standardization of measurements of environmental allergen exposure.Google Scholar
  37. 37.
    Gore JC, Schal C. Gene expression and tissue distribution of the major human allergen Bla g 1 in the German cockroach, Blattella germanica L. (Dictyoptera: Blattellidae). J Med Entomol. 2004;41:953–60.PubMedGoogle Scholar
  38. 38.
    Gore JC, Schal C. Expression, production and excretion of Bla g 1, a major human allergen, in relation to food intake in the German cockroach, Blattella germanica. Med Vet Entomol. 2005;19:127–34.PubMedGoogle Scholar
  39. 39.
    Ferreira AH, Cristofoletti PT, Lorenzini DM, Guerra LO, Paiva PB, Briones MR, et al. Identification of midgut microvillar proteins from Tenebrio molitor and Spodoptera frugiperda by cDNA library screenings with antibodies. J Insect Physiol. 2007;53:1112–24.PubMedGoogle Scholar
  40. 40.
    Morlais I, Mori A, Schneider JR, Severson DW. A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti. Mol Genet Genomics. 2003;269:753–64.PubMedGoogle Scholar
  41. 41.
    Shao L, Devenport M, Fujioka H, Ghosh A, Jacobs-Lorena M. Identification and characterization of a novel peritrophic matrix protein, Ae-Aper50, and the microvillar membrane protein, AEG12, from the mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2005;35:947–59.PubMedGoogle Scholar
  42. 42.
    A. Pomés A, L.K.Arruda. Investigating cockroach allergens: Aiming to improve diagnosis and treatment of cockroach allergic patients. Methods. 2013 Aug 2. doi:pii: S1046-2023(13)00285-5. 10.1016/j.ymeth.2013.07.036. [Epub ahead of print]
  43. 43.
    Wünschmann S, Gustchina A, Chapman MD, Pomés A. Cockroach allergen Bla g 2: an unusual aspartic proteinase. J Allergy Clin Immunol. 2005;116:140–5.PubMedGoogle Scholar
  44. 44.
    Li M, Gustchina A, Alexandratos J, Wlodawer A, Wünschmann S, Kepley CL, et al. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem. 2008;283:22806–14.PubMedCentralPubMedGoogle Scholar
  45. 45.
    Li M, Gustchina A, Glesner J, Wünschmann S, Vailes LD, Chapman MD, et al. Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. J Immunol. 2011;186:333–40.PubMedCentralPubMedGoogle Scholar
  46. 46.
    Glesner J, Wünschmann S, Li M, Gustchina A, Wlodawer A, Himly M, et al. Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS One. 2011;6:e22223.PubMedCentralPubMedGoogle Scholar
  47. 47.
    Wu CH, Lan JL. Cockroach hypersensitivity: isolation and partial characterization of major allergens. J Allergy Clin Immunol. 1988;82:727–35.PubMedGoogle Scholar
  48. 48.
    Wu CH, Lee MF, Liao SC, Luo SF. Sequencing analysis of cDNA clones encoding the American cockroach Cr-PI allergens. Homology with insect hemolymph proteins. J Biol Chem. 1996;271:17937–43.PubMedGoogle Scholar
  49. 49.
    Mindykowski B, Jaenicke E, Tenzer S, Cirak S, Schweikardt T, Schild H, et al. Cockroach allergens Per a 3 are oligomers. Dev Comp Immunol. 2010;34:722–33.PubMedGoogle Scholar
  50. 50.
    Wu CH, Lee MF, Wang NM, Luo SF. Sequencing and immunochemical characterization of the American cockroach Per a 3 (Cr-PI) isoallergenic variants. Mol Immunol. 1997;34:1–8.PubMedGoogle Scholar
  51. 51.
    Smith W, Butler AJ, Hazell LA, Chapman MD, Pomés A, Nickels DG, et al. Fel d 4, a cat lipocalin allergen. Clin Exp Allergy. 2004;34:1732–8.PubMedGoogle Scholar
  52. 52.
    Konieczny A, Morgenstern JP, Bizinkauskas CB, Lilley CH, Brauer AW, Bond JF, et al. The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms. Immunology. 1997;92:577–86.PubMedCentralPubMedGoogle Scholar
  53. 53.
    Böcskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, et al. Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography. Nature. 1992;360:186–8.PubMedGoogle Scholar
  54. 54.
    Virtanen T, Kinnunen T. Mammalian allergens. Clin Allergy Immunol. 2008;21:201–18.PubMedGoogle Scholar
  55. 55.
    Virtanen T, Kinnunen T, Rytkönen-Nissinen M. Mammalian lipocalin allergens-insights into their enigmatic allergenicity. Clin Exp Allergy. 2012;42:494–504.PubMedGoogle Scholar
  56. 56.
    Nordlund B, Konradsen JR, Kull I, Borres MP, Önell A, Hedlin G, et al. IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. Allergy. 2012;67:661–9.PubMedGoogle Scholar
  57. 57.
    Fahlbusch B, Rudeschko O, Szilagyi U, Schlott B, Henzgen M, Schlenvoigt G, et al. Purification and partial characterization of the major allergen, Cav p 1, from guinea pig Cavia porcellus. Allergy. 2002;57:417–22.PubMedGoogle Scholar
  58. 58.
    Hilger C, Swiontek K, Kler S, Diederich C, Lehners C, Vogel L, et al. Evaluation of two new recombinant guinea-pig lipocalins, Cav p 2 and Cav p 3, in the diagnosis of guinea-pig allergy. Clin Exp Allergy. 2011;41:899–908.PubMedGoogle Scholar
  59. 59.
    Arruda LK, Vailes LD, Hayden ML, Benjamin DC, Chapman MD. Cloning of cockroach allergen, Bla g 4, identifies ligand binding proteins (or calycins) as a cause of IgE antibody responses. J Biol Chem. 1995;270:31196–201.PubMedGoogle Scholar
  60. 60.
    Fan Y, Gore JC, Redding KO, Vailes LD, Chapman MD, Schal C. Tissue localization and regulation by juvenile hormone of human allergen Bla g 4 from the German cockroach, Blattella germanica (L.). Insect Mol Biol. 2005;14:45–53.PubMedGoogle Scholar
  61. 61.
    Arruda LK, Vailes LD, Platts-Mills TA, Hayden ML, Chapman MD. Induction of IgE antibody responses by glutathione S-transferase from the German cockroach (Blattella germanica). J Biol Chem. 1997;272:20907–12.PubMedGoogle Scholar
  62. 62.
    Huang CH, Liew LM, Mah KW, Kuo IC, Lee BW, Chua KY. Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase. Clin Exp Allergy. 2006;36:369–76.PubMedGoogle Scholar
  63. 63.••
    Santiago HC, Leevan E, Bennuru S, Ribeiro-Gomes F, Mueller E, Wilson M, et al. Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization. J Allergy Clin Immunol. 2012;130:248–56. This is an intereseting study which showed that filarial infection in humans was associated with increased prevalence of cross-reactive IgE responses to Bla g 5 (cockroach GST), with possible clinical implications. Experimentally, mice infected with filaria developed anti-filaria GST IgE and showed immediate skin test reactivity to Bla g 5. It was shown that cockroach and helminth GST cross-react because of remarkable molecular and structural similarities.PubMedCentralPubMedGoogle Scholar
  64. 64.
    Santos AB, Chapman MD, Aalberse RC, Vailes LD, Ferriani VP, Oliver C, et al. Cockroach allergens and asthma in Brazil: identification of tropomyosin as a major allergen with potential cross-reactivity with mite and shrimp allergens. J Allergy Clin Immunol. 1999;104:329–37.PubMedGoogle Scholar
  65. 65.
    Reese G, Ayuso R, Lehrer SB. Tropomyosin: an invertebrate pan-allergen. Int Arch Allergy Immunol. 1999;119:247–58.PubMedGoogle Scholar
  66. 66.
    Santos AB, Rocha GM, Oliver C, Ferriani VP, Lima RC, Palma MS, et al. Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach. J Allergy Clin Immunol. 2008;121:1040–6.PubMedGoogle Scholar
  67. 67.
    Shanti KN, Martin BM, Nagpal S, Metcalfe DD, Rao PV. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. J Immunol. 1993;151:5354–63.PubMedGoogle Scholar
  68. 68.
    Asturias JA, Gómez-Bayón N, Arilla MC, Martínez A, Palacios R, Sánchez-Gascón F, et al. Molecular characterization of American cockroach tropomyosin (Periplaneta americana allergen 7), a cross-reactive allergen. J Immunol. 1999;162:4342–8.PubMedGoogle Scholar
  69. 69.
    Leung PS, Chu KH, Chow WK, Ansari A, Bandea CI, Kwan HS, et al. Cloning, expression, and primary structure of Metapenaeus ensis tropomyosin, the major heat-stable shrimp allergen. J Allergy Clin Immunol. 1994;94:882–90.PubMedGoogle Scholar
  70. 70.
    Lopata AL, O'Hehir RE, Lehrer SB. Shellfish allergy. Clin Exp Allergy. 2010;40:850–8.PubMedGoogle Scholar
  71. 71.
    Yang AC, Arruda LK, Santos AB, Barbosa MC, Chapman MD, Galvão CE, et al. Measurement of IgE antibodies to shrimp tropomyosin is superior to skin prick testing with commercial extract and measurement of IgE to shrimp for predicting clinically relevant allergic reactions after shrimp ingestion. J Allergy Clin Immunol. 2010;125:872–8.PubMedGoogle Scholar
  72. 72.
    Gámez C, Sánchez-García S, Ibáñez MD, López R, Aguado E, López E, et al. Tropomyosin IgE-positive results are a good predictor of shrimp allergy. Allergy. 2011;66:1375–83.PubMedGoogle Scholar
  73. 73.
    Reese G, Schicktanz S, Lauer I, Randow S, Lüttkopf D, Vogel L, et al. Structural, immunological and functional properties of natural recombinant Pen a 1, the major allergen of Brown Shrimp, Penaeus aztecus. Clin Exp Allergy. 2006;36:517–24.PubMedGoogle Scholar
  74. 74.
    Ayuso R, Reese G, Leong-Kee S, Plante M, Lehrer SB. Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of shrimp, house dust mite and cockroach tropomyosins. Int Arch Allergy Immunol. 2002;129:38–48.PubMedGoogle Scholar
  75. 75.
    Jenkins JA, Breiteneder H, Mills EN. Evolutionary distance from human homologs reflects allergenicity of animal food proteins. J Allergy Clin Immunol. 2007;120:1399–405.PubMedGoogle Scholar
  76. 76.
    Hindley J, Wünschmann S, Satinover SM, Woodfolk JA, Chew FT, Chapman MD, et al. Bla g 6: a troponin C allergen from Blattella germanica with IgE binding calcium dependence. J Allergy Clin Immunol. 2006;117:1389–95.PubMedGoogle Scholar
  77. 77.
    Ayuso R, Grishina G, Bardina L, Carrillo T, Blanco C, Ibáñez MD, et al. Myosin light chain is a novel shrimp allergen, Lit v 3. J Allergy Clin Immunol. 2008;122:795–802.PubMedGoogle Scholar
  78. 78.
    Yu CJ, Lin YF, Chiang BL, Chow LP. Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J Immunol. 2003;170:445–53.PubMedGoogle Scholar
  79. 79.
    Binder M, Mahler V, Hayek B, Sperr WR, Scholler M, Prozell S, et al. Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen. J Immunol. 2001;167:5470–7.PubMedGoogle Scholar
  80. 80.
    Wongtim S, Lehrer SB, Salvaggio JE, Horner WE. Protease activity in cockroach and basidiomycete allergen extracts. Allergy Proc. 1993;14:263–8.PubMedGoogle Scholar
  81. 81.
    Sudha VT, Arora N, Gaur SN, Pasha S, Singh BP. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008;63:768–76.PubMedGoogle Scholar
  82. 82.
    Sudha VT, Arora N, Singh BP. Serine protease activity of Per a 10 augments allergen-induced airway inflammation in a mouse model. Eur J Clin Invest. 2009;39:507–16.PubMedGoogle Scholar
  83. 83.
    Goel C, Govindaraj D, Singh BP, Farooque A, Kalra N, Arora N. Serine protease Per a 10 from Periplaneta americana bias dendritic cells towards type 2 by upregulating CD86 and low IL-12 secretions. Clin Exp Allergy. 2012;42:412–22.PubMedGoogle Scholar
  84. 84.
    Govindaraj D, Gaur SN, Arora N. Characterization of recombinant Per a 10 from Periplaneta americana. Clin Vaccine Immunol. 2013;20:262–8.PubMedCentralPubMedGoogle Scholar
  85. 85.
    Patterson ML, Slater JE. Characterization and comparison of commercially available German and American cockroach allergen extracts. Clin Exp Allergy. 2002;32:721–7.PubMedGoogle Scholar
  86. 86.
    Slater JE, James R, Pongracic JA, Liu AH, Sarpong S, Sampson HA, et al. Biological potency of German cockroach allergen extracts determined in an inner city population. Clin Exp Allergy. 2007;37:1033–9.PubMedGoogle Scholar
  87. 87.
    Lopes MI, Miranda PJ, Sarinho E. Use of the skin prick test and specific immunoglobulin E for the diagnosis of cockroach allergy. J Pediatr (Rio J). 2006;82(3):204–9.Google Scholar
  88. 88.
    Londres MI, Sarinho FW, Miranda PJ, Solé D, Sarinho E. Allergy to cockroaches: challenges in diagnosis. Clin Lab. 2011;57:969–74.PubMedGoogle Scholar
  89. 89.••
    Portnoy J, Chew GL, Phipatanakul W, Williams PB, Grimes C, Kennedy K, et al. Environmental assessment and exposure reduction of cockroaches: A practice parameter. J Allergy Clin Immunol. 2013;132:802–8. An excellent review developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma & Immunology (ACAAI), and the Joint Council of Allergy, Asthma & Immunology on assessment of cockroach exposure and evidence-based recommendations to decrease levels of cockroach allergens in the environment, which could be beneficial to patients with cockroach-induced asthma.PubMedGoogle Scholar
  90. 90.
    Nowak-Wegrzyn AH, Bencharitiwong R, Schwarz J, David G, Eggleston P, Gergen PJ, et al. Mediator release assay for assessment of biological potency of German cockroach allergen extracts. J Allergy Clin Immunol. 2009;123:949–55.PubMedCentralPubMedGoogle Scholar
  91. 91.
    Satinover SM, Reefer AJ, Pomés A, Chapman MD, Platts-Mills TA, Woodfolk JA. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. J Allergy Clin Immunol. 2005;115:803–9.PubMedGoogle Scholar
  92. 92.
    Pittner G, Vrtala S, Thomas WR, Weghofer M, Kundi M, Horak F, et al. Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens. Clin Exp Allergy. 2004;34:597–603.PubMedGoogle Scholar
  93. 93.
    Weghofer M, Thomas WR, Kronqvist M, Mari A, Purohit A, Pauli G, et al. Variability of IgE reactivity profiles among European mite allergic patients. Eur J Clin Invest. 2008;38:959–65.PubMedGoogle Scholar
  94. 94.
    Westritschnig K, Sibanda E, Thomas W, Auer H, Aspock H, Pittner G, et al. Analysis of the sensitization profile towards allergens in central Africa. Clin Exp Allergy. 2003;33:22–7.PubMedGoogle Scholar
  95. 95.
    Sereda MJ, Hartmann S, Lucius R. Helminths and allergy: the example of tropomyosin. Trends Parasitol. 2008;24:272–8.PubMedGoogle Scholar
  96. 96.
    Santiago HC, Bennuru S, Boyd A, Eberhard M, Nutman TB. Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis. J Allergy Clin Immunol. 2011;127:479–86.PubMedCentralPubMedGoogle Scholar
  97. 97.
    Fitzsimmons CM, Dunne DW. Survival of the fittest: allergology or parasitology? Trends Parasitol. 2009;25:447–51.PubMedGoogle Scholar
  98. 98.
    Lee MF, Song PP, Hwang GY, Lin SJ, Chen YH. Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. Ann Allergy Asthma Immunol. 2012;108:243–8.PubMedGoogle Scholar
  99. 99.
    Kang BC, Johnson J, Morgan C, Chang JL. The role of immunotherapy in cockroach asthma. J Asthma. 1988;25:205–18.PubMedGoogle Scholar
  100. 100.
    Alonso A, Albonico JF, Mouchian K, Scavini LM, Iraneta SG, Pionetti CH. Imunological changes during cockroach immunotherapy. J Investig Allergol Clin Immunol. 1999;9:299–304.PubMedGoogle Scholar
  101. 101.
    Srivastava D, Gaur SN, Arora N, Singh BP. Clinico-immunological changes post-immunotherapy with Periplaneta americana. Eur J Clin Invest. 2011;41:879–88.PubMedGoogle Scholar
  102. 102.••
    Wood RA, Togias A, Wildfire J, Visness CM, Matsui EC, Gruchalla R, et al. Development of cockroach immunotherapy by the Inner-City Asthma Consortium. J Allergy Clin Immunol. 2013. doi:10.1016/j.jaci.2013.08.047. This very recent study reports the outcomes of four pilot studies on SLIT and SCIT using B.germanica extract. The results showed that IT with cockroach is safe, and that SCIT appears to be more effective in terms of inducing immunological responses than SLIT. The studies reported in this publication provide the basis for continuing investigation of the efficacy of IT in treatment of cockroach-allergic patients with asthma, rhinitis, or both.Google Scholar
  103. 103.
    Pomés A, Chapman MD, Vailes LD, Blundell TL, Dhanaraj V. Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization. Am J Respir Crit Care Med. 2002;165:391–7.PubMedGoogle Scholar
  104. 104.
    Jeong KY, Lee J, Lee IY, Ree HI, Hong CS, Yong TS. Allergenicity of recombinant Bla g 7, German cockroach tropomyosin. Allergy. 2003;58:1059–63.PubMedGoogle Scholar
  105. 105.
    Jeong KY, Lee J, Lee IY, Ree HI, Hong CS, Yong TS. Analysis of amino acid sequence variations and immunoglobulin E-binding epitopes of German cockroach tropomyosin. Clin Diagn Lab Immunol. 2004;11:874–8.PubMedCentralPubMedGoogle Scholar
  106. 106.
    Wu CH, Hsieh MJ, Huang JH, Luo SF. Identification of low molecular weight allergens of American cockroach and production of monoclonal antibodies. Ann Allergy Asthma Immunol. 1996;76:195–203.PubMedGoogle Scholar
  107. 107.
    Wu CH, Wang NM, Lee MF. Sequencing analysis of a cDNA encoding the American cockroach (Periplaneta americana) Cr-PII allergen. Allergy Clin Immunol Int Suppl. 1997;4:11.Google Scholar
  108. 108.
    Wang NM, Lee MF, Wu CH. Immunologic characterization of a recombinant American cockroach (Periplaneta americana) Per a 1 (Cr-PII) allergen. Allergy. 1999;54:119–27.PubMedGoogle Scholar
  109. 109.
    Sookrung N, Chaicumpa W, Tungtrongchitr A, Vichyanond P, Bunnag C, Ramasoota P, et al. Periplaneta americana arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. Environ Health Perspect. 2006;114:875–80.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • L. Karla Arruda
    • 1
  • Michelle C. R. Barbosa
    • 1
  • Ana Beatriz R. Santos
    • 2
  • Adriana S. Moreno
    • 1
  • Martin D. Chapman
    • 3
  • Anna Pomés
    • 3
  1. 1.Department of Medicine, Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoBrazil
  2. 2.Institute of Health SciencesPaulista University Campus CampinasCampinasBrazil
  3. 3.Indoor Biotechnologies, IncorporatedCharlottesvilleUSA

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