Etiology and Pathogenesis of Late-Onset Alzheimer’s Disease

BASIC AND APPLIED SCIENCE (M FRIERI AND PJ BRYCE, SECTION EDITORS)
Part of the following topical collections:
  1. Topical Collection on Basic and Applied Science

Abstract

Alzheimer’s disease (AD) is a neurodegenerative condition that occurs in two forms, an early-onset form that is genetically determined and a far more common late-onset form that is not. In both cases, the disease results in severe cognitive dysfunction, among other problems, and the late-onset form of the disease is now considered to be the most common cause of dementia among the elderly. While a good deal of research has been focused on elucidating the etiology of the late-onset form for more than two decades, results to date have been modest and have not yet engendered useful therapeutic strategies for cure of the disease. In this review, we discuss the prevalent ideas that have governed this research for several years, and we challenge these ideas with alternative findings suggesting a multifactorial etiology. We review promising newer ideas that may prove effective as therapeutic interventions for late-onset AD, as well as providing reliable means of earlier and more specific diagnosis of the disease process. In the discussions included here, we reference relevant clinical and basic science literature underlying research into disease etiology and pathogenesis, and we highlight current reviews on the various topics addressed.

Keywords

Alzheimer’s disease Late onset Amyloid cascade hypothesis Inflammation Infection Neuropathogenesis Etiology Pathogenesis Diagnosis 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pathology, Microbiology, Immunology, and Forensic MedicinePhiladelphia College of Osteopathic MedicinePhiladelphiaUSA
  2. 2.Department of Immunology and MicrobiologyWayne State University School of MedicineDetroitUSA

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