Genetic Contributors to Otitis Media: Agnostic Discovery Approaches

  • E. Kaitlynn Allen
  • Ani Manichaikul
  • Michèle M. Sale
OTITIS (DP SKONER, SECTION EDITOR)
Part of the following topical collections:
  1. Topical Collection on Otitis

Abstract

Otitis media (OM) is the most common disease in children in the United States, with about $5 billion spent each year in direct and indirect costs. OM is the number one reason for pediatric antibiotic usage and surgery, although treatment options are limited. Numerous studies have established the high heritability of OM and a genetic contribution to OM pathogenesis. Candidate gene studies have highlighted the roles of inflammation, mucin secretion, and pathogen recognition, but this approach is unable to identify novel pathways to target for treatment or screening purposes. Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis.

Keywords

Otitis media Discovery Genome Candidate genes Population studies Genetics 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • E. Kaitlynn Allen
    • 1
    • 2
  • Ani Manichaikul
    • 1
    • 3
  • Michèle M. Sale
    • 1
    • 2
    • 4
  1. 1.Center for Public Health GenomicsUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of Biochemistry and Molecular GeneticsUniversity of VirginiaCharlottesvilleUSA
  3. 3.Department of Public Health Sciences, Division of Biostatistics and EpidemiologyUniversity of VirginiaCharlottesvilleUSA
  4. 4.Department of MedicineUniversity of VirginiaCharlottesvilleUSA

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