Genetic Contributors to Otitis Media: Agnostic Discovery Approaches
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Otitis media (OM) is the most common disease in children in the United States, with about $5 billion spent each year in direct and indirect costs. OM is the number one reason for pediatric antibiotic usage and surgery, although treatment options are limited. Numerous studies have established the high heritability of OM and a genetic contribution to OM pathogenesis. Candidate gene studies have highlighted the roles of inflammation, mucin secretion, and pathogen recognition, but this approach is unable to identify novel pathways to target for treatment or screening purposes. Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis.
KeywordsOtitis media Discovery Genome Candidate genes Population studies Genetics
Compliance with Ethics Guidelines
Conflict of Interest
Ani Manichaikul has received grant support from the Hearing Health Foundation.
E. Kaitlynn Allen and Michèle M. Sale declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with animal subjects performed by any of the authors. With regard to the authors’ research cited in this paper, all procedures were followed in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000 and 2008.
- 3.Daly KA, Hoffman HJ, Kvaerner KJ, Kvestad E, Casselbrant ML, Homoe P, et al. Epidemiology, natural history, and risk factors: panel report from the Ninth International Research Conference on Otitis Media. Int J Pediatr Otorhinolaryngol. 2010;74(3):231–40. doi: 10.1016/j.ijporl.2009.09.006.PubMedCrossRefGoogle Scholar
- 11.Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner SM, et al. Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010;19(20):4112–20. doi: 10.1093/hmg/ddq327.PubMedCrossRefGoogle Scholar
- 12.Fearnhead NS, Wilding JL, Winney B, Tonks S, Bartlett S, Bicknell DC, et al. Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. Proc Natl Acad Sci U S A. 2004;101(45):15992–7. doi: 10.1073/pnas.0407187101.PubMedCentralPubMedCrossRefGoogle Scholar
- 22.Allen EK, Chen WM, Weeks DE, Chen F, Hou X, Mattos JL, et al. A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2. J Assoc Res Otolaryngol: JARO. 2013. doi: 10.1007/s10162-013-0411-2.PubMedGoogle Scholar