Emerging Role of Human Basophil Biology in Health and Disease

  • Jessica L. Cromheecke
  • Kathleen T. Nguyen
  • David P. Huston
IMMUNE DEFICIENCY AND DYSREGULATION (DP HUSTON, SECTION EDITOR)

DOI: 10.1007/s11882-013-0408-2

Cite this article as:
Cromheecke, J.L., Nguyen, K.T. & Huston, D.P. Curr Allergy Asthma Rep (2014) 14: 408. doi:10.1007/s11882-013-0408-2
Part of the following topical collections:
  1. Topical Collection on Immune Deficiency and Dysregulation

Abstract

Basophils have emerged in recent years as a small but potent subpopulation of leukocytes capable of bridging innate and adaptive immunity. They can be activated through IgE-dependent and IgE-independent mechanisms to release preformed mediators and to produce Th2 cytokines. In addition to their role in protective immunity to helminths, basophils are major participants in allergic reactions as diverse as anaphylaxis and immediate hypersensitivity reactions, late-phase hypersensitivity reactions, and delayed hypersensitivity reactions. Additionally, basophils have been implicated in the pathophysiology of autoimmune diseases such as lupus nephritis and rheumatoid arthritis, and the modulation of immune responses to bacterial infections, as well as being a feature of myelogenous leukemias. Distinct signals for activation, degranulation, transendothelial migration, and immune regulation are being defined, and demonstrate the important role of basophils in promoting a Th2 microenvironment. These mechanistic insights are driving innovative approaches for diagnostic testing and therapeutic targeting of basophils.

Keywords

Basophil Allergy Anaphylaxis Autoimmunity Infection Malignancy 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jessica L. Cromheecke
    • 1
    • 2
  • Kathleen T. Nguyen
    • 1
    • 2
  • David P. Huston
    • 1
    • 2
  1. 1.Departments of Microbial Pathogenesis & Immunology and MedicineTexas A&M College of MedicineHoustonUSA
  2. 2.Texas A&M Health Science CenterClinical Science and Translational Research InstituteHoustonUSA

Personalised recommendations