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Systemic Contact Dermatitis and Allergy to Biomedical Devices

  • ALLERGIC SKIN DISEASES (L FONACIER, SECTION EDITOR)
  • Published:
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Abstract

Systemic contact dermatitis (SCD) refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross-reacting allergen via the systemic route. It occurs to allergens including metals, medications, and foods. There has been recent interest in metal allergy as it relates to the implantation of devices such as orthopedic, dental, cardiac, and gynecologic implants. This review will briefly address all causes of systemic contact dermatitis with a special and expanded focus on metal implant allergy. We present literature on SCD to various metal biomedical devices, patch testing for diagnosis of metal allergy pre and post implantation and treatment.

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References

Papers of particular interest, published recently, have been hihglighted as: • Of importance •• Of major importance

  1. • Winnicki M, Shear NH. A systematic approach to systemic contact dermatitis and symmetric drug-related intertriginous and flexural exanthema (SDRIFE): a closer look at these conditions and an approach to intertriginous eruptions. Am J Clin Dermatol. 2011;12(3):171–80. Evaluation of systemic contact dermatitis with special attention to symmetric drug-related intertriginous exanthema which is suggestive of medication-induced dermatitis in patients without previous history of cutaneous sensitization.

    Article  PubMed  Google Scholar 

  2. Veien NK. Systemic contact dermatitis. Int J Dermatol. 2011;50(12):1445–56.

    Article  PubMed  CAS  Google Scholar 

  3. Yoshihisa Y, Shimizu T. Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract. 2012;2012:749561.

    PubMed  Google Scholar 

  4. Andersen KE, Hjorth N, Menne T. The baboon syndrome: systemically-induced allergic contact dermatitis. Contact Dermatitis. 1984;10(2):97–100.

    Article  PubMed  CAS  Google Scholar 

  5. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis. 2002;47(4):189–98.

    Article  PubMed  Google Scholar 

  6. Rycroft RJ. Recurrent facial dermatitis from chamomile tea. Contact Dermatitis. 2003;48(4):229.

    Article  PubMed  Google Scholar 

  7. Rodriguez-Serna M, Sanchez-Motilla JM, Ramon R, Aliaga A. Allergic and systemic contact dermatitis from Matricaria chamomilla tea. Contact Dermatitis. 1998;39(4):192–3.

    Article  PubMed  CAS  Google Scholar 

  8. Cusack C, Buckley C. Compositae dermatitis in a herbal medicine enthusiast. Contact Dermatitis. 2005;53(2):120–1.

    Article  PubMed  CAS  Google Scholar 

  9. Fonacier LS, Aquino MR, Mucci T. Current strategies in treating severe contact dermatitis in pediatric patients. Curr Allergy Asthma Rep. 2012;12(6):599–606.

    Article  PubMed  Google Scholar 

  10. Herro EM, Jacob SE. Systemic Contact Dermatitis - Kids and Ketchup. Pediatr Dermatol. May 2013;30(3):e32–3.

  11. Salam TN, Fowler Jr JF. Balsam-related systemic contact dermatitis. J Am Acad Dermatol. 2001;45(3):377–81.

    Article  PubMed  CAS  Google Scholar 

  12. Lowther A, McCormick T, Nedorost S. Systemic contact dermatitis from propylene glycol. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Mar-Apr 2008;19(2):105–108

    Google Scholar 

  13. • Scheman A, Cha C, Jacob SE, Nedorost S. Food avoidance diets for systemic, lip, and oral contact allergy: an american contact alternatives group article. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Nov-Dec 2012;23(6):248–257. Food avoidance may be helpful in patients with systemic contact dermatitis, particularly if sensitized to propylene glycol, an emerging contact allergen.

  14. Warshaw EM, Belsito DV, Taylor JS, et al. North American Contact Dermatitis Group patch test results: 2009 to 2010. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Mar-Apr 2013;24(2):50–59

    Google Scholar 

  15. Guin JD, Phillips D. Erythroderma from systemic contact dermatitis: a complication of systemic gentamicin in a patient with contact allergy to neomycin. Cutis. 1989;43(6):564–7.

    PubMed  CAS  Google Scholar 

  16. Hausermann P, Harr T, Bircher AJ. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis. 2004;51(5–6):297–310.

    Article  PubMed  CAS  Google Scholar 

  17. Zug KA, Warshaw EM, Fowler JF, Jr., et al. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. May-Jun 2009;20(3):149–160

    Google Scholar 

  18. Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007;73(5):307–12.

    Article  PubMed  Google Scholar 

  19. Brandao MH, Gontijo B, Girundi MA, de Castro MC. Ear piercing as a risk factor for contact allergy to nickel. J Pediatr (Rio J). 2010;86(2):149–54.

    Article  Google Scholar 

  20. • Thyssen JP. Nickel and cobalt allergy before and after nickel regulation--evaluation of a public health intervention. Contact Dermatitis. 2011;65 Suppl 1:1–68. Investigated the presence of nickel and cobalt in consumer items after the implementation of the EU nickel directive and demonstrated decreased rates of nickel allergy in females.

    Article  Google Scholar 

  21. Cadosch D, Chan E, Gautschi OP, Simmen HP, Filgueira L. Bio-corrosion of stainless steel by osteoclasts–in vitro evidence. J Orthop Res : Off Publ Orthop Res Soc. 2009;27(7):841–6.

    Article  CAS  Google Scholar 

  22. Okazaki Y, Gotoh E, Manabe T, Kobayashi K. Comparison of metal concentrations in rat tibia tissues with various metallic implants. Biomaterials. 2004;25(28):5913–20.

    Article  PubMed  CAS  Google Scholar 

  23. Dorr LD, Bloebaum R, Emmanual J, Meldrum R. Histologic, biochemical, and ion analysis of tissue and fluids retrieved during total hip arthroplasty. Clin Orthop Relat Res. 1990;261:82–95.

    PubMed  Google Scholar 

  24. Jacobs JJ, Skipor AK, Patterson LM, et al. Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study. J Bone Joint Surg Br. 1998;80(10):1447–58. American volume.

    CAS  Google Scholar 

  25. Savarino L, Granchi D, Ciapetti G, et al. Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings. J Biomed Mater Res. 2002;63(5):467–74.

    Article  PubMed  CAS  Google Scholar 

  26. Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg Am Vol. 2000;82(4):457–76.

    CAS  Google Scholar 

  27. Cadosch D, Chan E, Gautschi OP, Filgueira L. Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening–current concepts. J Biomed Mater Res Part A. 2009;91(4):1252–62.

    Article  CAS  Google Scholar 

  28. Honari G, Ellis SG, Wilkoff BL, Aronica MA, Svensson LG, Taylor JS. Hypersensitivity reactions associated with endovascular devices. Contact Dermatitis. 2008;59(1):7–22.

    Article  PubMed  Google Scholar 

  29. Thomas P, Summer B, Sander CA, Przybilla B, Thomas M, Naumann T. Intolerance of osteosynthesis material: evidence of dichromate contact allergy with concomitant oligoclonal T-cell infiltrate and TH1-type cytokine expression in the peri-implantar tissue. Allergy. 2000;55(10):969–72.

    Article  PubMed  CAS  Google Scholar 

  30. Gamerdinger K, Moulon C, Karp DR, et al. A new type of metal recognition by human T cells: contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel. J Exp Med. 2003;197(10):1345–53.

    Article  PubMed  CAS  Google Scholar 

  31. Messer RL, Wataha JC, Lewis JB, Lockwood PE, Caughman GB, Tseng WY. Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells. J Long-Term Eff Med Implants. 2005;15(1):39–47.

    Article  PubMed  CAS  Google Scholar 

  32. Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bull NYU Hosp Joint Dis. 2009;67(2):182–8.

    Google Scholar 

  33. Granchi D, Ciapetti G, Savarino L, et al. Effects of bone cement extracts on the cell-mediated immune response. Biomaterials. 2002;23(4):1033–41.

    Article  PubMed  CAS  Google Scholar 

  34. Watters TS, Cardona DM, Menon KS, Vinson EN, Bolognesi MP, Dodd LG. Aseptic lymphocyte-dominated vasculitis-associated lesion: a clinicopathologic review of an underrecognized cause of prosthetic failure. Am J Clin Pathol. 2010;134(6):886–93.

    Article  PubMed  Google Scholar 

  35. Greenfield EM, Beidelschies MA, Tatro JM, Goldberg VM, Hise AG. Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem. 2010;285(42):32378–84.

    Article  PubMed  CAS  Google Scholar 

  36. Takagi M, Tamaki Y, Hasegawa H, et al. Toll-like receptors in the interface membrane around loosening total hip replacement implants. J Biomed Mater Res Part A. 2007;81(4):1017–26.

    Article  CAS  Google Scholar 

  37. Schmidt M, Raghavan B, Muller V, et al. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol. 2010;11(9):814–9.

    Article  PubMed  CAS  Google Scholar 

  38. 316/316L Stainless Steel Product Data Sheet. http://www.aksteel.com/pdf/markets_products/stainless/austenitic/316_316L_Data_Sheet.pdf

  39. ASTM CoCr alloy. http://www.arcam.com/wp-content/uploads/Arcam-ASTM-F75-Cobalt-Chrome.pdf. Accessed April 20th, 2013

  40. Tilsley DA, Rotstein H. Sensitivity caused by internal exposure to nickel, chrome and cobalt. Contact Dermatitis. 1980;6(3):175–8.

    Article  PubMed  CAS  Google Scholar 

  41. Benson MK, Goodwin PG, Brostoff J. Metal sensitivity in patients with joint replacement arthroplasties. Br Med J. 1975;4(5993):374–5.

    Article  PubMed  CAS  Google Scholar 

  42. Elves MW, Wilson JN, Scales JT, Kemp HB. Incidence of metal sensitivity in patients with total joint replacements. Brit Med J. 1975;4(5993):376–8.

    Article  PubMed  CAS  Google Scholar 

  43. Gawkrodger DJ. Nickel sensitivity and the implantation of orthopaedic prostheses. Contact Dermatitis. 1993;28(5):257–9.

    Article  PubMed  CAS  Google Scholar 

  44. Thomas RH, Rademaker M, Goddard NJ, Munro DD. Severe eczema of the hands due to an orthopaedic plate made of Vitallium. Br Med J (Clin Res Ed). 1987;294(6564):106–7.

    Article  CAS  Google Scholar 

  45. Hallab N, Merritt K, Jacobs JJ. Metal sensitivity in patients with orthopaedic implants. J Bone Joint Surg Am Vol. 2001;83-A(3):428–36.

    CAS  Google Scholar 

  46. Thomas P, Bandl WD, Maier S, Summer B, Przybilla B. Hypersensitivity to titanium osteosynthesis with impaired fracture healing, eczema, and T-cell hyperresponsiveness in vitro: case report and review of the literature. Contact Dermatitis. 2006;55(4):199–202.

    Article  PubMed  CAS  Google Scholar 

  47. Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009;17(2):69–76.

    PubMed  Google Scholar 

  48. Back DL, Young DA, Shimmin AJ. How do serum cobalt and chromium levels change after metal-on-metal hip resurfacing? Clin Orthop Relat Res. 2005;438:177–81.

    Article  PubMed  Google Scholar 

  49. Gleizes V, Poupon J, Lazennec JY, Chamberlin B, Saillant G. [Value and limits of determining serum cobalt levels in patients with metal on metal articulating prostheses]. Rev Chir Orthop Reparatrice Appar Mot. 1999;85(3):217–25.

    PubMed  CAS  Google Scholar 

  50. MacDonald SJ, McCalden RW, Chess DG, et al. Metal-on-metal versus polyethylene in hip arthroplasty: a randomized clinical trial. Clin Orthop Relat Res. 2003;406:282–96.

    Article  PubMed  Google Scholar 

  51. Schaffer AW, Pilger A, Engelhardt C, Zweymueller K, Ruediger HW. Increased blood cobalt and chromium after total hip replacement. J Toxicol Clin Toxicol. 1999;37(7):839–44.

    Article  PubMed  CAS  Google Scholar 

  52. • Basko-Plluska JL, Thyssen JP, Schalock PC. Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Mar-Apr 2011;22(2):65–79. A very thorough review of metal allergy to orthopedic implants, gynecologic implants, and cardiac stents.

  53. Ridley CM. How relevant is cobalt sensitivity in a patient with an unsatisfactory total knee replacement? Clin Exp Dermatol. 1977;2(4):401–4.

    Article  PubMed  CAS  Google Scholar 

  54. Munro-Ashman D, Miller AJ. Rejection of metal to metal prosthesis and skin sensitivity to cobalt. Contact Dermatitis. 1976;2(2):65–7.

    Article  PubMed  CAS  Google Scholar 

  55. Symeonides PP, Paschaloglou C, Papageorgiou S. An allergic reaction after internal fixation of a fracture using a vitallium plate. J Allergy Clin Immunol. 1973;51(4):251–2.

    Article  PubMed  CAS  Google Scholar 

  56. Mikhael MM, Hanssen AD, Sierra RJ. Failure of metal-on-metal total hip arthroplasty mimicking hip infection. A report of two cases. J Bone Joint Surg Am Vol. 2009;91(2):443–6.

    Article  Google Scholar 

  57. Campbell P, Shimmin A, Walter L, Solomon M. Metal sensitivity as a cause of groin pain in metal-on-metal hip resurfacing. J Arthroplast. 2008;23(7):1080–5.

    Article  Google Scholar 

  58. Jensen P, Thyssen JP, Retpen JB, Menne T. Cobalt allergy and suspected aseptic lymphocyte-dominated vascular-associated lesion following total hip arthroplasty. Contact Dermatitis. 2009;61(4):238–9.

    Article  PubMed  Google Scholar 

  59. Reed KB, Davis MD, Nakamura K, Hanson L, Richardson DM. Retrospective evaluation of patch testing before or after metal device implantation. Arch Dermatol. 2008;144(8):999–1007.

    Article  PubMed  Google Scholar 

  60. Kieffer M. Nickel sensitivity: relationship between history and patch test reaction. Contact Dermatitis. 1979;5(6):398–401.

    Article  PubMed  CAS  Google Scholar 

  61. Carlsson A, Moller H. Implantation of orthopaedic devices in patients with metal allergy. Acta Derm Venereol. 1989;69(1):62–6.

    PubMed  CAS  Google Scholar 

  62. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA : J Am Med Assoc. 2000;283(15):2008–12.

    Article  CAS  Google Scholar 

  63. Granchi D, Cenni E, Giunti A, Baldini N. Metal hypersensitivity testing in patients undergoing joint replacement: a systematic review. J Bone Joint Surg Brit Vol. 2012;94(8):1126–34.

    Article  CAS  Google Scholar 

  64. Granchi D, Cenni E, Trisolino G, Giunti A, Baldini N. Sensitivity to implant materials in patients undergoing total hip replacement. J Biomed Mater Res Part B Appl Biomater. 2006;77(2):257–64.

    Article  PubMed  CAS  Google Scholar 

  65. Frigerio E, Pigatto PD, Guzzi G, Altomare G. Metal sensitivity in patients with orthopaedic implants: a prospective study. Contact Dermatitis. 2011;64(5):273–9.

    Article  PubMed  CAS  Google Scholar 

  66. Krecisz B, Kiec-Swierczynska M, Chomiczewska-Skora D. Allergy to orthopedic metal implants - a prospective study. Int J Occup Med Environ Health. 2012;25(4):463–9.

    Article  PubMed  Google Scholar 

  67. Bircher A, Friederich NF, Seelig W, Scherer K. Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement. Contact Dermatitis. 2012;66(1):20–6.

    Article  PubMed  CAS  Google Scholar 

  68. •• Schalock PC, Menne T, Johansen JD, et al. Hypersensitivity reactions to metallic implants - diagnostic algorithm and suggested patch test series for clinical use. Contact Dermatitis. 2012;66(1):4–19. A very useful review with information on patch testing in patients with suspected metal allergy due to biomedical devices.

    Article  PubMed  CAS  Google Scholar 

  69. Thyssen JP, Jakobsen SS, Engkilde K, Johansen JD, Soballe K, Menne T. The association between metal allergy, total hip arthroplasty, and revision. Acta Orthop. 2009;80(6):646–52.

    Article  PubMed  Google Scholar 

  70. Koster R, Vieluf D, Kiehn M, et al. Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis. Lancet. 2000;356(9245):1895–7.

    Article  PubMed  CAS  Google Scholar 

  71. Iijima R, Ikari Y, Amiya E, et al. The impact of metallic allergy on stent implantation: metal allergy and recurrence of in-stent restenosis. Int J Cardiol. 2005;104(3):319–25.

    Article  PubMed  Google Scholar 

  72. Hillen U, Haude M, Erbel R, Goos M. Evaluation of metal allergies in patients with coronary stents. Contact Dermatitis. 2002;47(6):353–6.

    Article  PubMed  CAS  Google Scholar 

  73. Norgaz T, Hobikoglu G, Serdar ZA, et al. Is there a link between nickel allergy and coronary stent restenosis? Tohoku J Exp Med. 2005;206(3):243–6.

    Article  PubMed  CAS  Google Scholar 

  74. Saito T, Hokimoto S, Oshima S, Noda K, Kojyo Y, Matsunaga K. Metal allergic reaction in chronic refractory in-stent restenosis. Cardiovasc Revascularization Med: Incl Mol Interv. 2009;10(1):17–22.

    Article  Google Scholar 

  75. Hansen PR, Ahlehoff O, Gislason GH, Galloe AM, Menne T, Thyssen JP. Absence of metal allergy in patients with very late drug-eluting stent thrombosis: a pilot study. Int J Cardiol. 2010;145(3):629–30.

    Article  PubMed  Google Scholar 

  76. Groot ACd. Patch testing : test concentrations and vehicles for 3700 chemicals. 2nd ed. Amsterdam ; New York: Elsevier; 1994

  77. Keane FM, Morris SD, Smith HR, Rycroft RJ. Allergy in coronary in-stent restenosis. Lancet. 2001;357(9263):1205–6. author reply 1206–1207.

    Article  PubMed  CAS  Google Scholar 

  78. Kastrati A, Schomig A, Dirschinger J, et al. Increased risk of restenosis after placement of gold-coated stents: results of a randomized trial comparing gold-coated with uncoated steel stents in patients with coronary artery disease. Circulation. 2000;101(21):2478–83.

    Article  PubMed  CAS  Google Scholar 

  79. Park SJ, Lee CW, Hong MK, et al. Comparison of gold-coated NIR stents with uncoated NIR stents in patients with coronary artery disease. Am J Cardiol. 2002;89(7):872–5.

    Article  PubMed  CAS  Google Scholar 

  80. vom Dahl J, Haager PK, Grube E, et al. Effects of gold coating of coronary stents on neointimal proliferation following stent implantation. Am J Cardiol. 2002;89(7):801–5.

    Article  Google Scholar 

  81. Svedman C, Tillman C, Gustavsson CG, Moller H, Frennby B, Bruze M. Contact allergy to gold in patients with gold-plated intracoronary stents. Contact Dermatitis. 2005;52(4):192–6.

    Article  PubMed  CAS  Google Scholar 

  82. Ekqvist S, Svedman C, Moller H, et al. High frequency of contact allergy to gold in patients with endovascular coronary stents. Br J Dermatol. 2007;157(4):730–8.

    Article  PubMed  CAS  Google Scholar 

  83. Virmani R, Guagliumi G, Farb A, et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109(6):701–5.

    Article  PubMed  Google Scholar 

  84. Nebeker JR, Virmani R, Bennett CL, et al. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47(1):175–81.

    Article  PubMed  Google Scholar 

  85. FDA Document-Amplatzer. Summary of Safety and Probable Benefit. 2000; http://www.fda.gov/ohrms/dockets/ac/01/briefing/3790b1_03_sponsorss&e.pdf. Accessed 5/1/2013

  86. FDA Document: CardioSEALO Septal Occlusion System with Qwik LoadO Summary of Safety and Effectiveness Data. 2001

  87. Ries MW, Kampmann C, Rupprecht HJ, Hintereder G, Hafner G, Meyer J. Nickel release after implantation of the Amplatzer occluder. Am Hear J. 2003;145(4):737–41.

    Article  CAS  Google Scholar 

  88. Singh HR, Turner DR, Forbes TJ. Nickel allergy and the amplatzer septal occluder. J Invasive Cardiol. 2004;16(11):681–2.

    PubMed  Google Scholar 

  89. Fukahara K, Minami K, Reiss N, Fassbender D, Koerfer R. Systemic allergic reaction to the percutaneous patent foramen ovale occluder. J Thorac Cardiovasc Surg. 2003;125(1):213–4.

    Article  PubMed  Google Scholar 

  90. Raque C, Goldschmidt H. Dermatitis associated with an implanted cardiac pacemaker. Arch Dermatol. 1970;102(6):646–9.

    Article  PubMed  CAS  Google Scholar 

  91. Ishii K, Kodani E, Miyamoto S, et al. Pacemaker contact dermatitis: The effective use of a polytetrafluoroethylene sheet. Pacing Clin Electrophysiol: PACE. 2006;29(11):1299–302.

    Article  PubMed  Google Scholar 

  92. Weiss R. Pacemaker dermatitis. Contact Dermatitis. 1989;21(5):343–4.

    Article  PubMed  CAS  Google Scholar 

  93. Buchet S, Blanc D, Humbert P, et al. Pacemaker dermatitis. Contact Dermatitis. 1992;26(1):46–7.

    Article  PubMed  CAS  Google Scholar 

  94. Tamenishi A, Usui A, Oshima H, Ueda Y. Entirely polytetrafluoroethylene coating for pacemaker system contact dermatitis. Interact Cardiovasc Thorac Surg. 2008;7(2):275–7.

    Article  PubMed  Google Scholar 

  95. Yashiro B, Shoda M, Tomizawa Y, Manaka T, Hagiwara N. Long-term results of a cardiovascular implantable electronic device wrapped with an expanded polytetrafluoroethylene sheet. J Artif Organs: Off J Jpn Soc Artif Organs. 2012;15(3):244–9.

    Article  CAS  Google Scholar 

  96. Andrews ID, Scheinman P. Systemic hypersensitivity reaction (without cutaneous manifestations) to an implantable cardioverter-defibrillator. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. May 2011;22(3):161–164

  97. Oprea ML, Schnoring H, Sachweh JS, Ott H, Biertz J, Vazquez-Jimenez JF. Allergy to pacemaker silicone compounds: recognition and surgical management. Ann Thorac Surg. 2009;87(4):1275–7.

    Article  PubMed  Google Scholar 

  98. Rushing GD, Goretsky MJ, Gustin T, Morales M, Kelly Jr RE, Nuss D. When it is not an infection: metal allergy after the Nuss procedure for repair of pectus excavatum. J Pediatr Surg. 2007;42(1):93–7.

    Article  PubMed  Google Scholar 

  99. Castellani C, Schalamon J, Saxena AK, Hoellwarth ME. Early complications of the Nuss procedure for pectus excavatum: a prospective study. Pediatr Surg Int. 2008;24(6):659–66.

    Article  PubMed  Google Scholar 

  100. Aneja S, Taylor JS, Soldes O, DiFiore J. Dermatitis in patients undergoing the Nuss procedure for correction of pectus excavatum. Contact Dermatitis. 2011;65(6):317–21.

    Article  PubMed  Google Scholar 

  101. Ditrichova D, Kapralova S, Tichy M, et al. Oral lichenoid lesions and allergy to dental materials. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007;151(2):333–9.

    Article  PubMed  Google Scholar 

  102. Issa Y, Duxbury AJ, Macfarlane TV, Brunton PA. Oral lichenoid lesions related to dental restorative materials. Br Dent J. 2005;198(6):361–6. disussion 549; quiz 372.

    Article  PubMed  CAS  Google Scholar 

  103. McParland H, Warnakulasuriya S. Oral lichenoid contact lesions to mercury and dental amalgam–a review. J Biomed Biotechnol. 2012;2012:589569.

    Article  PubMed  CAS  Google Scholar 

  104. Raap U, Stiesch M, Reh H, Kapp A, Werfel T. Investigation of contact allergy to dental metals in 206 patients. Contact Dermatitis. 2009;60(6):339–43.

    Article  PubMed  Google Scholar 

  105. Khamaysi Z, Bergman R, Weltfriend S. Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations. Contact Dermatitis. 2006;55(4):216–8.

    Article  PubMed  CAS  Google Scholar 

  106. Szyfelbein Masterpol K, Gottlieb AB, Scheinman PL. Systemic contact dermatitis presenting as lichen planus of the lip. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Jul-Aug 2010;21(4):218–219

    Google Scholar 

  107. Pigatto PD, Zerboni R, Guzzi G. Local and systemic allergic contact dermatitis due to dental alloys. J Eur Acad Dermatol Venereol. 2008;22(1):124–6.

    PubMed  CAS  Google Scholar 

  108. Shimizu T, Kobayashi S, Tanaka M. Systemic contact dermatitis to zinc in dental fillings. Clin Exp Dermatol. 2003;28(6):675–6.

    Article  PubMed  CAS  Google Scholar 

  109. Saito N, Yamane N, Matsumura W, et al. Generalized exacerbation of systemic allergic dermatitis due to zinc patch test and dental treatments. Contact Dermatitis. 2010;62(6):372–3.

    Article  PubMed  Google Scholar 

  110. Pigatto PD, Guzzi G. Systemic contact dermatitis from nickel associated with orthodontic appliances. Contact Dermatitis. 2004;50(2):100–1.

    Article  PubMed  CAS  Google Scholar 

  111. Kerosuo H, Kanerva L. Systemic contact dermatitis caused by nickel in a stainless steel orthodontic appliance. Contact Dermatitis. 1997;36(2):112–3.

    Article  PubMed  CAS  Google Scholar 

  112. Hubler Jr WR, Hubler Sr WR. Dermatitis from a chromium dental plate. Contact Dermatitis. 1983;9(5):377–83.

    Article  PubMed  Google Scholar 

  113. Purello D'Ambrosio F, Ricciardi L, Isola S, et al. Systemic contact dermatitis to copper-containing IUD. Allergy. 1996;51(9):658–9.

    PubMed  Google Scholar 

  114. Zurawin RK, Zurawin JL. Adverse events due to suspected nickel hypersensitivity in patients with essure micro-inserts. J Minim Invasive Gynecol. 2011;18(4):475–82.

    Article  PubMed  Google Scholar 

  115. Bibas N, Lassere J, Paul C, Aquilina C, Giordano-Labadie F. Nickel-induced systemic contact dermatitis and intratubal implants: the baboon syndrome revisited. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. Jan-Feb 2013;24(1):35–36

    Google Scholar 

  116. Al-Safi Z, Shavell VI, Katz LE, Berman JM. Nickel hypersensitivity associated with an intratubal microinsert system. Obstet Gynecol. 2011;117(2 Pt 2):461–2.

    Article  PubMed  Google Scholar 

  117. Josefson A, Farm G, Meding B. Validity of self-reported nickel allergy. Contact Dermatitis. 2010;62(5):289–93.

    Article  PubMed  Google Scholar 

  118. Thyssen JP, Menne T, Schalock PC, Taylor JS, Maibach HI. Pragmatic approach to the clinical work-up of patients with putative allergic disease to metallic orthopaedic implants before and after surgery. Br J Dermatol. 2011;164(3):473–8.

    PubMed  CAS  Google Scholar 

  119. Treudler R, Simon JC. Benzoyl peroxide: is it a relevant bone cement allergen in patients with orthopaedic implants? Contact Dermatitis. 2007;57(3):177–80.

    Article  PubMed  CAS  Google Scholar 

  120. Haddad FS, Cobb AG, Bentley G, Levell NJ, Dowd PM. Hypersensitivity in aseptic loosening of total hip replacements. The role of constituents of bone cement. J Bone Joint Surg Brit Vol. 1996;78(4):546–9.

    CAS  Google Scholar 

  121. Mowad CM. Practice gap: the role of patch testing in the selection and management of metal device implants. Arch Dermatol. 2012;148(6):693–4.

    Article  Google Scholar 

  122. Lai DW, Saver JL, Araujo JA, Reidl M, Tobis J. Pericarditis associated with nickel hypersensitivity to the Amplatzer occluder device: a case report. Catheter Cardiovasc Interv. 2005;66(3):424–6.

    Article  PubMed  Google Scholar 

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Conflict of Interest

Marcella Aquino has been treasurer and a board member of the Long Island Allergy & Asthma Society; has served as principal investigator on a clinical trial for Merck & Co.-SPIRO; has served as a sub-investigator on clinical trials for Novartis, Genentech, Baxter, and Dyax. Corp.; has been paid for giving lectures by the ACAAI; has had travel expenses covered/reimbursed for travel to meetings by the ACAAI; and has had travel expenses covered/reimbursed for travel to investigators’ meetings by Merck & Co.

Tania Mucci declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Section of Allergy and Clinical Immunology, Winthrop-University Hospital, Mineola, NY, USA

    Marcella Aquino & Tania Mucci

  2. Rheumatology, Allergy & Immunology, Winthrop University Hospital, 120 Mineola Blvd, Suite 410, Mineola, NY, 11501, USA

    Marcella Aquino & Tania Mucci

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  1. Marcella Aquino
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  2. Tania Mucci
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Correspondence to Marcella Aquino.

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Aquino, M., Mucci, T. Systemic Contact Dermatitis and Allergy to Biomedical Devices. Curr Allergy Asthma Rep 13, 518–527 (2013). https://doi.org/10.1007/s11882-013-0365-9

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  • DOI: https://doi.org/10.1007/s11882-013-0365-9

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