Clinical Consequences of Targeting IL-17 and TH17 in Autoimmune and Allergic Disorders
The TH17 lineage of T cells and its canonical cytokine IL-17 have been the focus of many recent studies in autoimmune, allergic, and infectious disease. In this review, we will briefly discuss the current knowledge about the role of these cells and IL-17 in a spectrum of disorders. It is clear that IL-17 plays pathogenic roles in certain conditions while the same pathway is critically important to immunity in others. Targeting of TH17 cells or IL-17 therapeutically may impart many benefits, but this approach is not without potentially serious implications regarding host defense. These issues will be discussed herein as we evaluate pharmacological approaches targeting this pathway that are just beginning to be fully tested in human disease.
KeywordsInflammation Immunity Host defense Allergy Asthma Lung Arthritis Psoriasis Lupus Crohn’s disease Pneumonia Multiple sclerosis IL-17 Th17 Autoimmune
Compliance with Ethics Guidelines
Conflict of Interest
John F. Alcorn has received grant support from the National Institutes of Health, National Heart, Lung, & Blood Institute, Janssen Research and Development, and Gilead.
Keven M. Robinson declares that she has no conflict of interest.
Michelle L. Manni declares that she has no conflict of interest.
Partha S. Biswas declares that he has no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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