Current Allergy and Asthma Reports

, Volume 13, Issue 5, pp 453–461

Asthma Microbiome Studies and the Potential for New Therapeutic Strategies

ASTHMA (WJ CALHOUN AND SP PETERS, SECTION EDITORS)

Abstract

Recent applications of culture-independent tools for microbiome profiling have revealed significant relationships between asthma and microbiota associated with the environment, gut, or airways. Studies of the airway microbiome in particular represent a new frontier in pulmonary research. Although these studies are relatively new, current evidence suggests the possibility of new therapeutic strategies for the treatment or prevention of asthma. In this article, recent literature on microbiota and asthma are critically reviewed, with a particular focus on studies of the airway microbiome. Perspectives are presented on how growing knowledge of relationships between the microbiome and asthma is likely to translate into improved understanding of asthma pathogenesis, its heterogeneity, and opportunities for novel treatment approaches.

Keywords

Asthma Microbiome 16S ribosomal RNA Microarray Sequencing Therapy Respiratory microbiota Treatment-resistant asthma 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Pulmonary, Critical Care, Allergy, and Sleep MedicineUniversity of California San FranciscoSan FranciscoUSA

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