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Current Allergy and Asthma Reports

, Volume 13, Issue 3, pp 298–307 | Cite as

Virus/Allergen Interactions in Asthma

  • Monica L. Gavala
  • Hiba Bashir
  • James E. Gern
ALLERGENS (RK BUSH, SECTION EDITOR)

Abstract

Understanding the underlying mechanisms that cause and exacerbate allergic asthmatic disease is of great clinical interest. Clinical studies have revealed that allergies and viral respiratory illnesses are strongly linked to the inception and exacerbation of asthma, and suggest the possibility that there are interactive inflammatory mechanisms. Recent work has revealed a number of mechanisms of virus and allergen cross-talk that may play a role in the pathophysiology of allergic asthma, including (1) deficiency in virus-induced interferon responses, (2) defective epithelial barrier function, (3) increased release of epithelium-derived cytokines (e.g., thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, IL-33), (4) dysregulation of lymphocytes [e.g., innate lymphoid cells (ILCs), regulatory T cells (Tregs)], and (5) altered activation of purinergic receptors. One or more of these processes may provide targets for new therapeutics to treat allergic asthma and prevent disease exacerbation.

Keywords

Asthma Virus Allergen Atopy Interactions Rhinovirus Exacerbations eATP TSLP IL-33 IL-25 Treg ILC P2X7 FcεR1 Dendritic cells 

Notes

Conflict of Interest

Monica L. Gavala declares that she has no conflict of interest.

Hiba Bashir declares that she has no conflict of interest.

James E. Gern has served as a consultant for GlaxoSmithKline, Biota Pharmaceuticals, Centocor, Boehringer Ingelheim GmbH, MedImmune, Theraclone Sciences, Merck & Co., and Gilead Sciences, and has received grant support from AstraZeneca, GlaxoSmithKline, and Merck & Co.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Monica L. Gavala
    • 1
  • Hiba Bashir
    • 2
  • James E. Gern
    • 3
  1. 1.Department of Biomolecular ChemistrySchool of Medicine and Public Health, University of Wisconsin-MadisonMadisonUSA
  2. 2.Department of MedicineUniversity of Wisconsin Medical SchoolMadisonUSA
  3. 3.Departments of Pediatrics and MedicineUniversity of Wisconsin Medical SchoolMadisonUSA

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