Current Allergy and Asthma Reports

, Volume 13, Issue 2, pp 203–208 | Cite as

Role of Leukotriene Antagonists and Antihistamines in the Treatment of Allergic Rhinitis

  • Bengü Çobanoğlu
  • Elina Toskala
  • Ahmet Ural
  • Cemal Cingi


Allergic rhinitis is the most common atopic disorder seen in ENT clinics. It is diagnosed by history, physical exam and objective testing. Patient education, environmental control measures, pharmacotherapy, and allergen-specific immunotherapy are the cornerstones of allergic rhinitis treatment and can significantly reduce the burden of disease. Current treatment guidelines include antihistamines, intranasal corticosteroids, oral and intranasal decongestants, intranasal anticholinergics, intranasal cromolyn, and leukotriene receptor antagonists. In the mechanism of allergic rhinitis, histamine is responsible for major allergic rhinitis symptoms such as rhinorrhea, nasal itching and sneezing. Its effect on nasal congestion is less evident. In contrast, leukotrienes result in increase in nasal airway resistance and vascular permeability. Antihistamines and leukotriene receptor antagonists are commonly used in the treatment of allergic rhinitis. The published literature about combined antihistamines and leukotriene antagonists in mono- or combination therapy is reviewed and presented.


Allergic rhinitis Early phase Late phase Antihistamines Montelukast Leukotrienes Leukotriene antagonists Treatment Histamine 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bengü Çobanoğlu
    • 1
  • Elina Toskala
    • 2
  • Ahmet Ural
    • 3
  • Cemal Cingi
    • 4
  1. 1.Department of Otolaryngology-Head Neck SurgeryTrabzon Research and Training HospitalTrabzonTurkey
  2. 2.Department of Otolaryngology-Head and Neck SurgeryTemple University, School of MedicinePhiladelphiaUSA
  3. 3.Department of Otolaryngology-Head Neck SurgeryKaradeniz Technical University, School of MedicineTrabzonTurkey
  4. 4.Department of Otolaryngology-Head Neck SurgeryEskisehir Osmangazi University, School of MedicineEskişehirTurkey

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