Current Allergy and Asthma Reports

, Volume 12, Issue 5, pp 465–477

Time for New Methods for Avoidance of House Dust Mite and Other Allergens



Asthma is a common disease in which environmental exposures and lifestyle factors play critical roles in expression and symptoms. Recommended methods for reducing exposure to domestic allergens as a component of asthma and rhinitis management have changed little over the last 30 years. The data that implementation of these provides clinical benefit are inconsistent. We contend that current methods are ineffective at reducing chronic personal exposure. More effective strategies can be developed based on understanding when people are exposed, the sources of this exposure and the activities associated with this exposure. Developing new methods should be founded on understanding the aerodynamic behavior of particles, their aerosolization, removal from surfaces, and the complex relationships between exposures and clinical outcomes. It will also require developing better proxy measures of chronic exposure, identifying markers for the sub-set of people who benefit, and integrating this with strategies addressing other domestic exposures and lifestyle factors.


Allergen Aeroallergen Avoidance Intervention Asthma Reaerosolization Personal exposure Methods HDM House dust mite 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Matsui EC. Role of environmental control in the management of asthma and allergy. J Allergy Clin Immunol. 2012;129:271–2. e1–3.PubMedCrossRefGoogle Scholar
  2. 2.
    Arshad SH. Environmental control for secondary prevention of asthma. Clin Exp Allergy. 2010;40:2–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Rao D, Phipatanakul W. Impact of environmental controls on childhood asthma. Curr Allergy Asthma Rep. 2011;11:414–20.Google Scholar
  4. 4.
    Bush RK. Does allergen avoidance work? Immunol Allergy Clin North Am. 2011;31:493–507.PubMedCrossRefGoogle Scholar
  5. 5.
    •• Tovey ER, Marks GB. It's time to rethink mite allergen avoidance. J Allergy Clin Immunol. 2011;128:723–7. e1–6. Heralds the first significant divergence from traditional approaches to HDM allergen avoidance and provides more detailed review of the complexity of the environmental drivers of asthma and the potential of allergen avoidance to be clinically effective. The current article focuses on the practical framework of how to achieve this. Google Scholar
  6. 6.
    To T, Stanojevic S, Moores G, Gershon A, Bateman E, Cruz A, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health. 2012:204;12:204.Google Scholar
  7. 7.
    Bousquet J, Kiley J, Bateman ED, Viegi G, Cruz AA, Khaltaev N, et al. Prioritized research agenda for prevention and control of chronic respiratory diseases. Eur Respir J. 2010;36:995–1001.PubMedCrossRefGoogle Scholar
  8. 8.
    National Heart, Lung and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma: 2007. Available at Accessed January 2012.
  9. 9.
    Global strategy for asthma management and prevention 2009.Available at Accessed January 2012.
  10. 10.
    British guideline on the management of asthma. 2009. Available from: Accessed January 2012.
  11. 11.
    Haahtela T, von Hertzen L, Makela M, Hannuksela M. Finnish Allergy Programme 2008-2018 - time to act and change the course. Allergy. 2008;63:634–45.PubMedCrossRefGoogle Scholar
  12. 12.
    von Hertzen LC, Savolainen J, Hannuksela M, Klaukka T, Lauerma A, Makela MJ, et al. Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance. Allergy. 2009;64:678–701.CrossRefGoogle Scholar
  13. 13.
    Simpson A, Custovic A. Prevention of allergic sensitization by environmental control. Curr Allergy Asthma Rep. 2009;9:363–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Martinez FD. New insights into the natural history of asthma: primary prevention on the horizon. J Allergy Clin Immunol. 2011;128:939–45.PubMedCrossRefGoogle Scholar
  15. 15.
    Gotzsche PC, Johansen HK. House dust mite control measures for asthma: systematic review. Allergy. 2008;63:646–59.PubMedCrossRefGoogle Scholar
  16. 16.
    Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, et al. Results of a home-based environmental intervention among urban children with asthma. N Eng J Med. 2004;351:1068–80.CrossRefGoogle Scholar
  17. 17.
    Takaro TK, Krieger J, Song L, Sharify D, Beaudet N. The breathe-easy home: the impact of asthma-friendly home construction on clinical outcomes and trigger exposure. Am J Public Health. 2011;101:55–62.PubMedCrossRefGoogle Scholar
  18. 18.
    Xu Y, Raja S, Ferro AR, Jaques PA, Hopke PK, Gressani C, et al. Effectiveness of heating, ventilation and air conditioning system with HEPA filter unit on indoor air quality and asthmatic children's health. Build Environ. 2010;45:330–7.CrossRefGoogle Scholar
  19. 19.
    Crocker DD, Hopkins D, Kinyota S, Dumitru G, Herman E, Ligon C. A systematic review of home-based multi-trigger multi-component environmental interventions to reduce asthma morbidity. J Allergy Clin Immunol. 2009;123:63.CrossRefGoogle Scholar
  20. 20.
    Boyle R, Pedroletti C, Wickman M, Bjermer L, Valovirta E, Dahl R, et al. Nocturnal temperature controlled laminar airflow for treating atopic asthma: a randomized controlled trial. Thorax. 2012;67:215–21.PubMedCrossRefGoogle Scholar
  21. 21.
    Stillerman A, Nachtsheim C, Li W, Albrecht M, Waldman J. Efficacy of a novel air filtration pillow for avoidance of perennial allergens in symptomatic adults. Ann Allergy Asthma Immunol. 2010;104:440–9.PubMedCrossRefGoogle Scholar
  22. 22.
    van Leeuwen WS, Eintoven Jr W, Kremer W. The allergen-proof chamber in the treatment of bronchial asthma and other respiratory diseases. Lancet. 1927;1:287–9.Google Scholar
  23. 23.
    •• Arrandale VH, Brauer M, Brook JR, Brunekreef B, Gold DR, London SJ, et al. Exposure assessment in cohort studies of childhood asthma. Environ Health Perspect. 2011;119:591–7. Provides a comprehensive overview of the issues, which make the measurement of environmental exposures in asthma a challenge and suggests strategies for improving such measurements in longitudinal cohort studies.PubMedCrossRefGoogle Scholar
  24. 24.
    Holt PG, Rowe J, Kusel M, Parsons F, Hollams EM, Bosco A, et al. Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study. J Allergy Clin Immunol. 2010;125:653–9.PubMedCrossRefGoogle Scholar
  25. 25.
    de Jongste JC, Carraro S, Hop WC, Baraldi E, Grp CS. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 2009;179:93–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-ige) for asthma in inner-city children. N Eng J Med. 2011;364:1005–15.CrossRefGoogle Scholar
  27. 27.
    Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61:376–82.PubMedCrossRefGoogle Scholar
  28. 28.
    Tovey E, Marks G. Methods and effectiveness of environmental control. J Allergy Clin Immunol. 1999;103:179–91.PubMedCrossRefGoogle Scholar
  29. 29.
    Sakaguchi M, Inouye S, Yasueda H, Irie T, Yoshizawa S, Shida T. Measurement of allergens associated with dust mite allergy. II. concentrations of airborne mite allergens (Der i and Der ii) in the house. Int Arch Allergy Appl Immunol. 1989;90:190–3.PubMedCrossRefGoogle Scholar
  30. 30.
    Poulos LM, O'Meara TJ, Sporik R, Tovey ER. Detection of inhaled Der p 1. Clin Exp Allergy. 1999;29:1232–8.PubMedCrossRefGoogle Scholar
  31. 31.
    De Lucca SD, O'Meara T. J, Tovey ER. Exposure to mite and cat allergens on a range of clothing items at home and the transfer of cat allergen in the workplace. J Allergy Clin Immunol. 2000;106:874–9.PubMedCrossRefGoogle Scholar
  32. 32.
    O'Rourke SD, Tovey ER, O'Meara T. J. personal exposure to mite and cat allergens. J Allergy Clin Immunol. 2002;109(Suppl):S47.CrossRefGoogle Scholar
  33. 33.
    Marriott C, O'Meara T, Salome CM, Tovey ER. The impact of bed encasing on the nocturnal der p 1 exposure and asthma. J Allergy Clin Immunol. 2004;113:S22.CrossRefGoogle Scholar
  34. 34.
    Mites, Asthma and Domestic Design 5. Mite allergens and myths. Available at: Accessed January 2012.
  35. 35.
    •• Raja S, Xu Y, Ferro AR, Jaques PA, Hopke PK. Resuspension of indoor aeroallergens and relationship to lung inflammation in asthmatic children. Environ Int. 2010;36:8–14. This is perhaps the first paper (to be read in combination with reference 18, Xu), which comprehensively measures multiple aeroallergen and airborne endotoxin exposures in children throughout the day and night and includes addressing issues such as resuspension of dust from reservoirs. There is a wealth of information collected, which although underexplored, helps to establish new directions for such studies.PubMedCrossRefGoogle Scholar
  36. 36.
    • Esposito WA, Chew GL, Correa JC, Chillrud SN, Miller RL, Kinney PL. Quantitative measurement of airborne cockroach allergen in New York City apartments. Indoor Air. 2011;21:512–20. This is also part of the ‘new generation’ of studies examining chronic airborne exposure to allergens, including consideration of the size of their particles and aerodynamic behavior.PubMedCrossRefGoogle Scholar
  37. 37.
    Mites, Asthma and Domestic Design 5. The dose response relationships between asthma and allergen exposure. Available at: Accessed April 2012.
  38. 38.
    Marks GB, Tovey ER, Peat JK, Salome CM, Woolcock AJ. Variability and repeatability of house dust mite allergen measurement: implications for study design and interpretation. Clin Exp Allergy. 1995;25:1190–7.PubMedCrossRefGoogle Scholar
  39. 39.
    Mitakakis TZ, Mahmic A, Tovey ER. Comparison of vacuuming procedures for reservoir dust mite allergen on floors. J Allergy Clin Immunol. 2002;109:122–4.PubMedCrossRefGoogle Scholar
  40. 40.
    Gore RB, Hadi EA, Craven M, Smillie FI, O'Meara TJ, Tovey ER, et al. Intra-nasal air sampling and reservoir house dust in the quantitation of Dermatophagoides pteronyssinus exposure. J Allergy Clin Immunol. 2001;107:S220.Google Scholar
  41. 41.
    O'Meara T, Tovey ER. Monitoring personal allergen exposure. Clin Rev Allergy Immunol. 2000;18:341–95.PubMedCrossRefGoogle Scholar
  42. 42.
    Glasgow NJ, Ponsonby AL, Kemp A, Tovey E, van Asperen P, McKay K, et al. Feather bedding and childhood asthma associated with house dust mite sensitization: a randomized controlled trial. Arch Dis Child. 2011;96:541–7.PubMedCrossRefGoogle Scholar
  43. 43.
    Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency particulate arrest-filter vacuum cleaners increase personal cat allergen exposure in homes with cats. J Allergy Clin Immunol. 2003;111:784–7.PubMedCrossRefGoogle Scholar
  44. 44.
    Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy. 2006;61:119–23.PubMedCrossRefGoogle Scholar
  45. 45.
    Gore RB, Bishop S, Durrell B, Curbishley L, Woodcock A, Custovic A. Air filtration units in homes with cats: can they reduce personal exposure to cat allergen? Clin Exp Allergy. 2003;33:765–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Lau J, Sercombe J, Rimmer JS, Tovey ER. Bed encasings reduce reservoir allergens but not aeroallergens. J Allergy Clin Immunol. 2006;117.Google Scholar
  47. 47.
    Wrzeszcz K, Sercombe JK, Tovey ER. Localized air filtration can reduce airborne der p 1 allergen concentration and airborne particle count in both disturbed and undisturbed conditions. J Allergy Clin Immunol. 2008;121:S92.Google Scholar
  48. 48.
    Gore R, Boyle RJ, Hanna H, Custovic A, Gore C, Svensson P, et al. Personal allergen exposure is increased by turning over in bed and improved by temperature-controlled laminar airflow. Clin Exp Allergy. 2011;41:1848.Google Scholar
  49. 49.
    • Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, et al. Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility. J Allergy Clin Immunol. 2011;128:390–396. e1–7. This study uses serial measurements of aeroallergen exposure to show that the types of antibody responses are functions of both the amount, and the variation of exposure. This extends our understanding of the clinical response to inhaled allergens. Google Scholar
  50. 50.
    Renstrom A. Exposure to airborne allergens: a review of sampling methods. J Environ Monit. 2002;4:619–22.PubMedCrossRefGoogle Scholar
  51. 51.
    De Lucca SD, Taylor DJM, O'Meara TJ, Jones AS, Tovey ER. Measurement and characterization of cockroach allergens detected during normal domestic activity. J Allergy Clin Immunol. 1999;104:672–80.PubMedCrossRefGoogle Scholar
  52. 52.
    Green BJ, O'Meara T, Sercombe JK, Tovey ER. Measurement of personal exposure to outdoor aeromycota in northern New South Wales, Australia. Ann Agric Environ Med. 2006;13:225–34.PubMedGoogle Scholar
  53. 53.
    Renstrom A, Karlsson AS, Tovey E. Nasal air sampling used for the assessment of occupational allergen exposure and the efficacy of respiratory protection. Clin Exp Allergy. 2002;32:1769–75.PubMedCrossRefGoogle Scholar
  54. 54.
    Custis NJ, Woodfolk JA, Vaughan JW, Platts-Mills TAE. Quantitative measurement of airborne allergens from dust mites, dogs, and cats using an ion-charging device. Clin Exp Allergy. 2003;33:986–91.PubMedCrossRefGoogle Scholar
  55. 55.
    Tovey E, De Lucca S, Poulos L, O'Meara T. The halogen assay: a new technique for measuring airborne allergen. In: Jones MG, Lympany P, editors. Methods in molecular medicine: allergy methods and protocols. Totowa: Humana Press Inc; 2008. p. 227–46.CrossRefGoogle Scholar
  56. 56.
    Wang Z, Shalat SL, Black K, Lioy PJ, Stambler AA, Emoekpere OH, et al. Use of a robotic sampling platform to assess young children's exposure to indoor bioaerosols. Indoor Air. 2012;22:159–69.PubMedCrossRefGoogle Scholar
  57. 57.
    • National Academy of Sciences. Using Personal Monitors and Sensors to Characterize Individual Exposures. Available at: Accessed January 2012. This is one talk from a great website containing many recent conference presentations about the new science of exposure measurement.
  58. 58.
    Liu DL, Nazaroff WW. Particle penetration through building cracks. Aerosol Sci Technol. 2003;37:565–73.CrossRefGoogle Scholar
  59. 59.
    Thatcher TL, Lai ACK, Moreno-Jackson R, Sextro RG, Nazaroff WW. Effects of room furnishings and air speed on particle deposition rates indoors. Atmos Environ. 2002;36:1811–9.CrossRefGoogle Scholar
  60. 60.
    Qian J, Ferro AR, Fowler KR. Estimating the resuspension rate and residence time of indoor particles. J Air Waste Manag Assoc. 2008;58:502–16.PubMedCrossRefGoogle Scholar
  61. 61.
    Custovic A, Woodcock H, Craven M, Hassall R, Hadley E, Simpson A, et al. Dust mite allergens are carried on not only large particles. Pediatr Allergy Immunol. 1999;10:258–60.PubMedCrossRefGoogle Scholar
  62. 62.
    Montoya LD, Hildemann LM. Size distributions and height variations of airborne particulate matter and cat allergen indoors immediately following dust-disturbing activities. J Aerosol Sci. 2005;36:735–49.CrossRefGoogle Scholar
  63. 63.
    Salares VR, Hinde CA, Miller JD. Analysis of settled dust in homes and fungal glucan in air particulate collected during HEPA vacuuming. Indoor Built Environ. 2009;18:485–91.CrossRefGoogle Scholar
  64. 64.
    Bogdanovic J, De Pater AJ, Doekes G, Wouters IM, Heederik DJJ. Application of porous foams for size selective measurements of airborne wheat allergen. Ann Occup Hyg. 2006;50:131–6.PubMedCrossRefGoogle Scholar
  65. 65.
    Zeidler MR, Goldin JG, Kleerup EC, Kim HJ, Truong DA, Gjertson DW, et al. Small airways response to naturalistic cat allergen exposure in subjects with asthma. J Allergy Clin Immunol. 2006;118:1075–81.PubMedCrossRefGoogle Scholar
  66. 66.
    Taylor PE, Jonsson H. Thunderstorm asthma. Curr Allergy Asthma Rep. 2004;4:409–13.PubMedCrossRefGoogle Scholar
  67. 67.
    Wood RA, Mudd KE, Eggleston PA. The distribution of cat and dust mite allergens on wall surfaces. J Allergy Clin Immunol. 1992;89:126–30.PubMedCrossRefGoogle Scholar
  68. 68.
    Sercombe J, Liu-Brennan D, Garcia M, Tovey ER. Evaluation of home allergen sampling devices. Allergy. 2005;60:515–20.PubMedCrossRefGoogle Scholar
  69. 69.
    • Samadi S, Heederik DJJ, Krop EJM, Jamshidifard AR, Willemse T, Wouters IM. Allergen and endotoxin exposure in a companion animal hospital. Occup Environ Med. 2010;67:486–92. This paper uses a range of sampling methods, including aeroallergen and wipe samples, to provide a comprehensive description of the sites and origins of exposure in an occupational setting.PubMedCrossRefGoogle Scholar
  70. 70.
    Karlsson AS, Hedren M, Almqvist C, Larsson K, Renstrom A. Evaluation of Petri dish sampling for assessment of cat allergen in airborne dust. Allergy. 2002;57:164–8.PubMedCrossRefGoogle Scholar
  71. 71.
    Raulf-Heimsoth M. Allergen quantification at workplace. Allergologie. 2008;31:142–6.Google Scholar
  72. 72.
    Corradi M, Romano C, Mutti A. Laboratory animal allergy. Med Lav. 2011;102:428–44.PubMedGoogle Scholar
  73. 73.
    Baur X, Sigsgaard T, Aasen TB, Burge PS, Heederik D, Henneberger P, et al. Guidelines for the management of work-related asthma. Eur Respir J. 2012;39:529–45.PubMedCrossRefGoogle Scholar
  74. 74.
    Fox AT, Sasieni P, du Toit G, Syed H, Lack G. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol. 2009;123:417–23.PubMedCrossRefGoogle Scholar
  75. 75.
    Brough H, Stephens A, Turcanu V, Lack G. Distribution of peanut in the home environment. Allergy. 2009;64:1428.Google Scholar
  76. 76.
    Matsumoto T, Miike T, Ono T. Mite-related allergy and oral tolerance. Allergy. 1996;51:276–7.PubMedGoogle Scholar
  77. 77.
    Doreswamy V, Peden DB. Modulation of asthma by endotoxin. Clin Exp Allergy. 2011;41:9–19.PubMedCrossRefGoogle Scholar
  78. 78.
    Simpson A, John SL, Jury F, Niven R, Woodcock A, Ollier WER, et al. Endotoxin exposure, CD14, and allergic disease - An interaction between genes and the environment. Am J Respir Crit Care Med. 2006;174:386–92.PubMedCrossRefGoogle Scholar
  79. 79.
    McCormack MC, Breysse PN, Matsui EC, Hansel NN, Peng RD, Curtin-Brosnan J, et al. Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Ann Allergy Asthma Immunol. 2011;106:308–15.PubMedCrossRefGoogle Scholar
  80. 80.
    • Rijssenbeek-Nouwens L, Fieten K, Bron A, Hashimoto S, Bel E, Weersink E. High altitude treatment in atopic and non-atopic patients with severe asthma. Eur Respir J. 2012 [Epub ahead of print 22 March]. While this paper confirms that severe asthma greatly improves when people are relocated from urban houses to mountain sanatoria, it shows that these improvements occur in both allergic and non-allergic subjects. This both confirms and questions the nature of environmental drivers of asthma. Google Scholar
  81. 81.
    Powe DG, Kormelink TG, Sisson M, Blokhuis BJ, Kramer MF, Jones NS, et al. Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis. J Allergy Clin Immunol. 2010;125:139–45.PubMedCrossRefGoogle Scholar
  82. 82.
    Burney PGJ, Newson RB, Burrows MS, Wheeler DM. The effects of allergens in outdoor air on both atopic and nonatopic subjects with airway disease. Allergy. 2008;63:542–6.PubMedCrossRefGoogle Scholar
  83. 83.
    Rabito FA, Carlson J, Holt EW, Iqbal S, James MA. Cockroach exposure independent of sensitization status and association with hospitalizations for asthma in inner-city children. Ann Allergy Asthma Immunol. 2011;106:103–9.PubMedCrossRefGoogle Scholar
  84. 84.
    Langley SJ, Goldthorpe S, Craven M, Woodcock A, Custovic A. Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitized, atopic asthmatic subjects. Thorax. 2005;60:17–21.PubMedCrossRefGoogle Scholar
  85. 85.
    Rivera-Mariani F, Bolaños-Rosero B. Allerg1enicity of airborne basidiospores and ascospores: need for further studies. Aerobiologia. 2012;28:83–97.CrossRefGoogle Scholar
  86. 86.
    Liu AH. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol. 2002;109:379–92.PubMedCrossRefGoogle Scholar
  87. 87.
    von Hertzen L, Hanski I, Haahtela T. Natural immunity. EMBO Rep. 2011;12:1089–93.CrossRefGoogle Scholar
  88. 88.
    Tovey ER, Kemp AS, Almqvist C, Sharland A, Marks GB. Do immune responses to inhaled skin flakes modulate the expression of allergic disease? Clin Exp Allergy. 2007;37:1199–203.PubMedCrossRefGoogle Scholar
  89. 89.
    Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P, et al. Early life environmental control - effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med. 2004;170:433–9.PubMedCrossRefGoogle Scholar
  90. 90.
    Gomes C, Frelhaut J, Bahnfleth W. Resuspension of allergen-containing particles under mechanical and aerodynamic disturbances from human walking. Atmos Environ. 2007;41:5257–70.CrossRefGoogle Scholar
  91. 91.
    Ferro AR, Kopperud RJ, Hildemann LM. Source strengths for indoor human activities that resuspend particulate matter. Environ Sci Technol. 2004;38:1759–64.PubMedCrossRefGoogle Scholar
  92. 92.
    Murakami S. Analysis and design of micro-climate around the human body with respiration by CFD. Indoor Air. 2004;14:144–56.PubMedCrossRefGoogle Scholar
  93. 93.
    • Tang JW, Noakes CJ, Nielsen PV, Eames I, Nicolle A, Li Y, et al. Observing and quantifying airflows in the infection control of aerosol- and airborne-transmitted diseases: an overview of approaches. J Hosp Infect. 2011;77:213–22. Although the paper concerns virus transmission it provides fascinating insight into the dynamics of particle movement associated with the human body.PubMedCrossRefGoogle Scholar
  94. 94.
    Chen Q, Hildemann LM. The effects of human activities on exposure to particulate matter and bioaerosols in residential homes. Environ Sci Technol. 2009;43:4641–6.PubMedCrossRefGoogle Scholar
  95. 95.
    • Qian J, Hospodsky D, Yamamoto N, Nazaroff W, Peccia J. Size-resolved emission rates of airborne bacteria and fungi in an occupied classroom. Indoor Air. 2012;epub Jan 18. This paper, uses a range of sophisticated gene-based detection methods, to examine the timing and size distribution of different and clinically-relevant biological particles under real exposure conditions. Google Scholar
  96. 96.
    • Delfino RJ, Staimer N, Tjoa T. Personal endotoxin exposure in a panel study of school children with asthma. Environ Health. 2011;10:69. The second paper (first is 98) to examine the ‘personal cloud’ of exposure to endotoxin, which is much higher than measurements made away from the person and is associated with activity.PubMedCrossRefGoogle Scholar
  97. 97.
    Rabinovitch N, Liu AH, Zhang LN, Rodes CE, Foarde K, Dutton SJ, et al. Importance of the personal endotoxin cloud in school-age children with asthma. J Allergy Clin Immunol. 2005;116:1053–7.PubMedCrossRefGoogle Scholar
  98. 98.
    Qian J, Ferro AR. Resuspension of dust particles in a chamber and associated environmental factors. Aerosol Sci Technol. 2008;42:566–78.CrossRefGoogle Scholar
  99. 99.
    Tovey ER, Taylor DJ, Mitakakis TZ, De Lucca SD. Effectiveness of laundry washing agents and conditions in the removal of cat and dust mite allergen from bedding dust. J Allergy Clin Immunol. 2001;108:369–74.PubMedCrossRefGoogle Scholar
  100. 100.
    McDonald LG, Tovey ER, Woolcock A. The role of water temperature and laundry procedures in reducing house dust mite populations and allergen content of bedding. J Allergy Clin Immunol. 1992;90:599–608.PubMedCrossRefGoogle Scholar
  101. 101.
    Mites Asthma and Domestic Design 5. Re-aerosolization of dust and fungal spores from flooring. Available at: Accessed April 2012.
  102. 102.
    Price JA, Pollock I, Little SA, Longbottom JL, Warner JO. Measurement of airborne mite antigen in the homes of asthmatic children. Lancet. 1990;336:895–7.PubMedCrossRefGoogle Scholar
  103. 103.
    Ferro AR, Kopperud RJ, Hildemann LM. Elevated personal exposure to particulate matter from human activities in a residence. J Expo Anal Environ Epidemiol. 2004;14:S34–40.PubMedCrossRefGoogle Scholar
  104. 104.
    Shaughnessy R, Vu V. Particle loadings and resuspension related to floor coverings in chamber and in occupied school environments. Atmospheric Environment. 2012;55:515–524.Google Scholar
  105. 105.
    Tian Y, Sul K, Howard-Reed C, Leber D, Ferro A. comparative study of estimating particle resuspension rate using a consistent test mechanism. Presented at the 12th International Conference on Indoor Air Quality and Climate (Indoor Air 2011), June 5–10, Austin, TX. 2011.Google Scholar
  106. 106.
    Sublett JL. Effectiveness of air filters and air cleaners in allergic respiratory diseases: a review of the recent literature. Curr Allergy Asthma Rep. 2011;11:395–402.PubMedCrossRefGoogle Scholar
  107. 107.
    • Portnoy J, Kennedy K, Sublett J. Environmental assessment and exposure control: a practice parameter-furry animals. Ann Allergy Asthma Immunol. 2012;108:223.e1–15. This is a recent and very comprehensive overview of the nature, components and evidence for exposure and removal from furry animals (mainly cats). Google Scholar
  108. 108.
    Karlsson AS, Andersson B, Renstrom A, Svedmyr J, Larsson K, Borres MP. Airborne cat allergen reduction in classrooms that use special school clothing or ban pet ownership. J Allergy Clin Immunol. 2004;113:1172–7.PubMedCrossRefGoogle Scholar
  109. 109.
    Nurmagambetov TA, Barnett SBL, Jacob V, Chattopadhyay SK, Hopkins DP, Crocker DD, et al. Economic value of home-based, multi-trigger, multicomponent interventions with an environmental focus for reducing asthma morbidity a community guide systematic review. Am J Prev Med. 2011;41:S33–47.PubMedCrossRefGoogle Scholar
  110. 110.
    Platts-Mills TAE, Mitchell EB, Nock P, Tovey ER, Moszoro H, Wilkins SR. Reduction of bronchial hyper-reactivity during prolonged allergen avoidance. Lancet. 1982;2:675–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Woolcock Institute of Medical Research, Sydney Medical SchoolUniversity of SydneySydneyAustralia
  2. 2.206 Rowley LaboratoriesClarkson UniversityPotsdamUSA

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