The Emerging Role of Interleukin-1β in Autoinflammatory Diseases
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The autoinflammatory syndromes are a group of multisystem disorders characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces in the absence of an immune reaction. Recent advances have revealed the importance of interleukin-1β, not only in the pathogenesis of many of these rare inherited diseases, but also in acquired diseases. The development and availability of anti–interleukin-1β therapeutics have introduced the possibility of proof-of-concept studies, which are likely to further widen this field.
KeywordsInterleukin-1 Inflammasome Autoinflammatory diseases Caspase-1 Cryopyrin NLRP3 CAPS Anakinra Rilonacept Canakinumab
Dr. Lachmann has received support from a European Union Framework 7 grant.
Dr. Lachmann has served as a consultant for Novartis and received honoraria and had travel/accommodations expenses covered by Novartis and Bristol-Myers Squibb.
Ms Lane reported no potential conflicts of interest relevant to this article.
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