The Emerging Role of Interleukin-1β in Autoinflammatory Diseases

Thirusha Lane; Helen J. Lachmann

doi:10.1007/s11882-011-0207-6

Current Allergy and Asthma Reports

October 2011, Volume 11, Issue 5, pp 361–368

The Emerging Role of Interleukin-1β in Autoinflammatory Diseases

Authors
Authors and affiliations

Thirusha Lane
Helen J. LachmannEmail author

Article

First Online:: 05 July 2011

10 Citations
336 Downloads

Abstract

The autoinflammatory syndromes are a group of multisystem disorders characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces in the absence of an immune reaction. Recent advances have revealed the importance of interleukin-1β, not only in the pathogenesis of many of these rare inherited diseases, but also in acquired diseases. The development and availability of anti–interleukin-1β therapeutics have introduced the possibility of proof-of-concept studies, which are likely to further widen this field.

Keywords

Interleukin-1 Inflammasome Autoinflammatory diseases Caspase-1 Cryopyrin NLRP3 CAPS Anakinra Rilonacept Canakinumab

References

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Thirusha Lane
- 1
Helen J. Lachmann
- 1
Email author

1.National Amyloidosis Centre, Division of MedicineUCL Medical School, Royal Free CampusLondonUK

The Emerging Role of Interleukin-1β in Autoinflammatory Diseases

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