Current Allergy and Asthma Reports

, Volume 11, Issue 4, pp 300–308 | Cite as

New Therapeutics in C1INH Deficiency: A Review of Recent Studies and Advances

Article

Abstract

Hereditary angioedema (HAE) is a genetic condition causing a significant burden of illness for affected individuals. Episodes of angioedema involving the skin, gastrointestinal tract, as well as the larynx and oropharynx are often unpredictable and cause significant morbidity and mortality. Isolation of the underlying protein deficiency, specifically the serine protease C1 inhibitor, and further description of its role in multiple physiologic cascades has led to the development of several specific therapies for HAE. This report provides a brief overview of HAE but focuses primarily on reviewing recently published clinical studies of therapeutics developed for medical management of the condition.

Keywords

Hereditary angioedema C1INH deficiency Ecallantide Icatibant C1 inhibitor protein Bradykinin Kallikrein Clinical studies Treatment Therapeutics 

Notes

Disclosure

Dr. Riedl has received grant support from Dyax Corp., CSL Behring, Shire, Pharming Group, and ViroPharma; has served on scientific advisory boards for Dyax Corp., CSL Behring, Shire, and ViroPharma; and has received payment for the development of continuing medical education presentations from the Robert Michael Educational Institute and Medscape.

Dr. Parikh reported no potential conflicts of interest relevant to this article.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Clinical Immunology and Allergy, Department of MedicineUCLA David Geffen School of MedicineLos AngelesUSA

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