Current Allergy and Asthma Reports

, Volume 11, Issue 4, pp 334–339

Immunologic Similarities between Selected Autoimmune Diseases and Peanut Allergy: Possible New Therapeutic Approaches

Article

DOI: 10.1007/s11882-011-0201-z

Cite this article as:
Martucci, M.A. & Dreskin, S.C. Curr Allergy Asthma Rep (2011) 11: 334. doi:10.1007/s11882-011-0201-z
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Abstract

Food allergies are an important medical problem in Westernized countries. Allergy to peanuts is a dramatic example of a food allergy that tends to be particularly severe and long-lived. This article examines food allergy—specifically peanut allergy—from the perspective that tolerance to foods is a normal state, just as tolerance to self-proteins is a normal state. From this vantage point, loss of tolerance to foods in food-allergic individuals can be viewed as parallel to the loss of tolerance to self-proteins in those with autoimmune diseases. Although our knowledge base is far from satisfactory, there are important similarities in the immunologic abnormalities that are characteristic of both peanut allergy and several autoimmune diseases. Delineation of these similarities may open the door to new therapeutic approaches for the treatment of severe food allergies.

Keywords

Peanut allergy Food allergy Autoimmunity Autoimmune diseases Peanuts Allergy Thyroiditis Myasthenia gravis Therapy 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Allergy and Clinical Immunology, Department of MedicineUniversity of Colorado Denver School of MedicineAuroraUSA
  2. 2.Division of Allergy and Immunology, Department of MedicineNational Jewish HealthDenverUSA

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