Xenotropic Murine Leukemia Virus-Related Virus in Chronic Fatigue Syndrome and Prostate Cancer
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Xenotropic murine leukemia virus-related virus (XMRV) is a γ retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer. The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients. The six strains of XMRV that have been sequenced have greater than 99% identity, indicating a new human infection rather than laboratory contamination. DNA, RNA, and proteins from XMRV have been detected in 50% to 67% of CFS patients and in about 3.7% of healthy controls. XMRV infections could be transmitted to permissive cell lines from CFS plasma, suggesting the potential for communicable and blood-borne spread of the virus and potentially CFS. This troubling concept is currently under intense evaluation. The most important steps now are to independently confirm the initial findings; develop reliable assays of biomarkers; and to move on to investigations of XMRV pathophysiology and treatment in CFS, prostate cancer, and potentially other virus-related syndromes, if they exist.
KeywordsXMRV Xenotropic murine leukemia virus-related virus Chronic fatigue syndrome CFS Prostate cancer Gamma-retrovirus Pseudoallergy Nonallergic rhinopathy
This work was supported by US Public Health Service Award RO1 ES015382 from the National Institute of Environmental and Health Sciences; Department of Defense Congressionally Directed Medical Research Program W81XWH-07-1-0618; and M01-RR13297 from the General Clinical Research Center Program, National Center for Research Resources, National Institutes of Health.
No potential conflict of interest relevant to this article was reported.
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