Current Allergy and Asthma Reports

, Volume 9, Issue 3, pp 179–185 | Cite as

Fatal anaphylaxis to foods: Epidemiology, recognition, and prevention

Article

Abstract

The inability to accurately predict the severity of future allergic reactions to foods in a given individual coupled with the real—although usually remote—risk of a fatal anaphylactic reaction complicates care and remains a constant source of concern to food-allergic patients, their family members, and health care providers. Current epidemiologic evidence suggests that the incidence of food-induced anaphylaxis is increasing, although confidently approximating the incidence of fatal allergic reactions to foods remains difficult. This article briefly reviews the epidemiology of fatal anaphylactic reactions to foods, discusses factors that may aid in identifying individuals at higher risk, emphasizes important aspects of patient education and prevention, and touches on the psychological impact of having a family member with food allergy.

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References and Recommended Reading

  1. 1.
    Sicherer SH, Sampson HA: Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol 2007, 120:491–503; quiz 504–505.PubMedCrossRefGoogle Scholar
  2. 2.
    Yocum MW, Butterfield JH, Klein JS, et al.: Epidemiology of anaphylaxis in Olmsted County: a population-based study. J Allergy Clin Immunol 1999, 104:452–456.PubMedCrossRefGoogle Scholar
  3. 3.
    Clark S, Bock SA, Gaeta TJ, et al.: Multicenter study of emergency department visits for food allergies. J Allergy Clin Immunol 2004, 113:347–352.PubMedCrossRefGoogle Scholar
  4. 4.
    Decker WW, Campbell RL, Manivannan V, et al.: The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008, 122:1161–1165.PubMedCrossRefGoogle Scholar
  5. 5.
    Bock SA, Muñoz-Furlong A, Sampson HA: Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001, 107:191–193.PubMedCrossRefGoogle Scholar
  6. 6.
    Yocum MW, Khan DA: Assessment of patients who have experienced anaphylaxis: a 3-year survey. Mayo Clin Proc 1994, 69:16–23.PubMedGoogle Scholar
  7. 7.
    Pumphrey RSH, Stanworth SJ: The clinical spectrum of anaphylaxis in north-west England. Clin Exp Allergy 1996, 26:1364–1370.PubMedCrossRefGoogle Scholar
  8. 8.
    Pumphrey RS: Life-threatening manifestations and fatal anaphylaxis to foods in children. In Food Allergy in Childhood: Causes and Consequences. Edited by Koletzko S. Heilbronn, Germany: SPS Verlagsgesellschaft mbH; 2007:106–112.Google Scholar
  9. 9.
    Moneret-Vautrin DA, Ganny G, Morisset M, et al.: Severe food anaphylaxis: 107 cases registered in 2002 by the Allergy Vigilance Network. Eur Ann Allergy Clin Immunol 2004, 36:46–51.PubMedGoogle Scholar
  10. 10.
    Pumphrey RS: Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000, 30:1144–1150.PubMedCrossRefGoogle Scholar
  11. 11.
    Colver AF, Nevantaus H, Macdougall CF, Cant AJ: Severe food-allergic reactions in children across the UK and Ireland, 1998–2000. Acta Paediatr 2005, 94:689–695.PubMedCrossRefGoogle Scholar
  12. 12.
    Krugman SD, Chiaramonte DR, Matsui EC: Diagnosis and management of food induced anaphylaxis: a national survey of pediatricians. Pediatrics 2006, 118:e554–e560.PubMedCrossRefGoogle Scholar
  13. 13.
    Bock SA, Munoz-Furlong A, Sampson HA: Further fatalities caused by anaphylactic reactions to food, 2001–2006 [letter]. J Allergy Clin Immunol 2007, 119:1016–1018.PubMedCrossRefGoogle Scholar
  14. 14.
    Pumphrey RSH, Gowland MH: Further fatal allergic reactions to food in the United Kingdom, 1999–2006 [letter]. J Allergy Clin Immunol 2007, 119:1018–1019.PubMedCrossRefGoogle Scholar
  15. 15.
    Lin RY, Anderson AS, Shah SN, Nurruzzaman F: Increasing anaphylaxis hospitalizations in the first 2 decades of life: New York state, 1990–2006. Ann Allergy Asthma Immunol 2008, 101:387–393.PubMedCrossRefGoogle Scholar
  16. 16.
    Lieberman P, Camargo CA, Bohlke K, et al.: Epidemiology of anaphylaxis: finding of the ACAAI Epidemiology of Anaphylaxis Working Group. Ann Allergy Asthma Immunol 2006, 97:596–602.PubMedGoogle Scholar
  17. 17.
    Simons FER, Sampson HA: Anaphylaxis epidemic: fact or fiction? J Allergy Clin Immunol 2008, 122:1166–1168.PubMedCrossRefGoogle Scholar
  18. 18.
    Sampson HA, Muñoz-Furlong A, Campbell RL, et al.: Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006, 117:391–397.PubMedCrossRefGoogle Scholar
  19. 19.
    Sampson MA, Muñoz-Furlong A, Sicherer SH: Risk-taking and coping strategies of adolescents and young adults with food allergy. J Allergy Clin Immunol 2006, 117:1440–1445.PubMedCrossRefGoogle Scholar
  20. 20.
    Vander Leek TK, Liu AH, Stefanski K, et al.: The natural history of peanut allergy in young children and its association with serum peanut-specific IgE. J Pediatr 2000, 137:749–755.CrossRefGoogle Scholar
  21. 21.
    Simons FER: First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol 2004, 113:837–844.PubMedGoogle Scholar
  22. 22.
    Pumphrey RS: Fatal posture in anaphylactic shock. J Allergy Clin Immunol 2003, 112:451–452.PubMedGoogle Scholar
  23. 23.
    Shreffler WG, Lencer DA, Bardina L, Sampson HA: IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol 2005, 116:893–899.PubMedCrossRefGoogle Scholar
  24. 24.
    Hourihane J’OB, Kilburn SA, Nordlee JA, et al.: An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study. J Allergy Clin Immunol 1997, 100:596–600.CrossRefGoogle Scholar
  25. 25.
    Wensing M, Penninks AH, Helfe SL, et al.: The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy. J Allergy Clin Immunol 2002, 110:915–920.PubMedCrossRefGoogle Scholar
  26. 26.
    Morrisset M, Moneret-Vautrin DA, Kanny G, et al.: Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin Exp Allergy 2003, 33:1046–1051.CrossRefGoogle Scholar
  27. 27.
    Osterballe M, Bindslev-Jensen C: Threshold levels in food challenge and specific IgE in patients with egg allergy: is there a relationship? J Allergy Clin Immunol 2003, 112:196–201.PubMedCrossRefGoogle Scholar
  28. 28.
    Crevel RWR, Ballmer-Wever BK, Holzhauser T, et al.: Thresholds for food allergens and their value to different stakeholders. Allergy 2008, 63:597–609.PubMedCrossRefGoogle Scholar
  29. 29.
    Sheikh A, ten Broek VM, Brown SGA, Simons FER: H1 antihistamines for the treatment of anaphylaxis with and without shock. Cochrane Database Syst Rev 2007, 1: CD006160.PubMedGoogle Scholar
  30. 30.
    Sheikh A, Shehata YA, Brown SG, Simons FE: Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. Cochrane Database Syst Rev 2008, 4: CD006312.PubMedGoogle Scholar
  31. 31.
    Skorpinski EW, McGeady SJ, Yousef E: Two cases of accidental epinephrine injection into a finger. J Allergy Clin Immunol 2006, 117:463–464.PubMedCrossRefGoogle Scholar
  32. 32.
    Primeau MN, Kagan R, Joseph L, et al.: The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy 2000, 30:1135–1143.PubMedCrossRefGoogle Scholar
  33. 33.
    Sicherer SH, Noone SA, Muñoz-Furlong A: The impact of childhood food allergy on quality of life. Ann Allergy Asthma Immunol 2001, 87:461–464.PubMedGoogle Scholar
  34. 34.
    Marklund B, Shlstedt S, Nordstrom G: Health-related quality of life in food hypersensitive schoolchildren and their families: parents’ perceptions. Health Qual Life Outcomes 2006, 4:48–60.PubMedCrossRefGoogle Scholar
  35. 35.
    Avery NJ, King RM, Knight S, Hourihane JO: Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol 2003, 14:378–382.PubMedCrossRefGoogle Scholar
  36. 36.
    Cohen BL, Noone S, Muñoz-Furlong A, Sicherer SH: Development of a questionnaire to measure quality of life in families with a child with food allergy. J Allergy Clin Immunol 2004, 114:1159–1163.PubMedCrossRefGoogle Scholar
  37. 37.
    DunnGalvin A, de BlokFlokstra BJM, Burks AW, et al.: Food allergy QOL questionnaire for children aged 0–12 years: content cross-cultural validity. Clin Exp Allergy 2008, 38:977–986.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  1. 1.National Jewish HealthDenverUSA

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