Intraocular inflammation: Its causes and investigations



Intraocular inflammation, or uveitis, incorporates a diverse group of infectious and immune-mediated disorders. In addition, some conditions masquerade as uveitis. However, classifying uveitis according to anatomic location in adult and pediatric populations, and appreciating the effect of immune status and regional differences, refines the list of potential causes. In this way, a select few investigations can be performed, rather than a nondirected battery of tests.

References and Recommended Reading

  1. 1.
    Bloch-Michel E, Nussenblatt RB: International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol 1987, 103:234–235.PubMedGoogle Scholar
  2. 2.
    Standardization of Uveitis Nomenclature (SUN) Working Group: Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005, 140:509–516.CrossRefGoogle Scholar
  3. 3.
    Chang JH, Wakefield D: Uveitis: a global perspective. Ocul Immunol Inflamm 2002, 10:263–279.PubMedCrossRefGoogle Scholar
  4. 4.
    Chang JH, McCluskey PJ, Wakefield D: Acute anterior uveitis and HLA-B27. Surv Ophthalmol 2005, 50:364–388.PubMedCrossRefGoogle Scholar
  5. 5.
    Huerta-Sil G, Casasola-Vargas JC, Londono JD, et al.: Low grade sacroiliitis as prognostic factor in patients with undifferentiated spondyloarthritis fulfilling diagnostic criteria for ankylosing spondylitis throughout follow-up. Ann Rheum Dis 2006, 65:642–646.PubMedCrossRefGoogle Scholar
  6. 6.
    Rothova A: Ocular involvement in sarcoidosis. Br J Ophthalmol 2000, 84:110–116.PubMedCrossRefGoogle Scholar
  7. 7.
    McCluskey P, Powell RJ: The eye in systemic inflammatory diseases. Lancet 2004, 364:2125–2133.PubMedCrossRefGoogle Scholar
  8. 8.
    Baarsma GS, La Hey E, Glasius E: The predictive value of serum angiotensin converting enzyme and lysozyme for the diagnosis of ocular sarcoidosis. Am J Ophthalmol 1987, 104:211–217.PubMedGoogle Scholar
  9. 9.
    Herpetic Eye Disease Study Group: A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. Arch Ophthalmol 1996, 114:1065–1072.Google Scholar
  10. 10.
    Van der Lelij A, Ooijman FM, Kijlstra A, et al.: Anterior uveitis with sectoral iris atrophy in the absence of keratitis. A distinct clinical entity among herpetic eye diseases. Ophthalmology 2000, 107:1164–1170.PubMedCrossRefGoogle Scholar
  11. 11.
    Singh R, Gupta V, Gupta A: Pattern of uveitis in a referral eye clinic in North India. Indian J Ophthalmol 2004, 52:121–125.PubMedGoogle Scholar
  12. 12.
    Wakabayashi T, Morimura Y, Miyamoto Y, et al.: Changing patterns of intraocular inflammatory disease in Japan. Ocul Immunol Inflamm 2003, 11:277–286.PubMedCrossRefGoogle Scholar
  13. 13.
    Wilhelmus KR, Lukehart SA: Syphilis. In Ocular Infection and Immunity. Edited by Pepose JS, Holland GN, Wilhelmus KR. Boston: Mosby; 1996:1437–1466.Google Scholar
  14. 14.
    Kiss S, Damico FM, Young LH: Ocular manifestations and treatment of syphilis. Semin Ophthalmol 2005, 20:161–167.PubMedCrossRefGoogle Scholar
  15. 15.
    Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines 2002. MMWR Morb Mortal Wkly Rep 2002, 51(RR-6):1–78.Google Scholar
  16. 16.
    Rathinam SR, Namperumalsamy P: Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol 2007, 55:173–183.PubMedGoogle Scholar
  17. 17.
    Chu KM, Rathinam SR, Namperumalsamy P, et al.: Identification of Leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in South India. J Infect Dis 1998, 177:1314–1321.PubMedGoogle Scholar
  18. 18.
    Kotaniemi K, Kautiainen H, Karma A, et al.: Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: a prospective study. Ophthalmology 2001, 108:2071–2075.PubMedCrossRefGoogle Scholar
  19. 19.
    Kotaniemi K, Savolainen A, Karma A, et al.: Recent advances in uveitis of juvenile idiopathic arthritis. Surv Ophthalmol 2003, 48:489–502.PubMedCrossRefGoogle Scholar
  20. 20.
    Reiff A: Ocular complications of childhood rheumatic diseases: uveitis. Curr Infect Dis Rep 2006, 8:459–468.CrossRefGoogle Scholar
  21. 21.
    Cassidy J, Kivlin J, Lindsley C, et al.: Ophthalmic examinations in children with juvenile rheumatoid arthritis. Paediatrics 2006, 117:1843–1845.CrossRefGoogle Scholar
  22. 22.
    Mackensen F, Smith JR, Rosenbaum JT.: Enhanced recognition, treatment and prognosis of tubulointerstitial nephritis and uveitis. Ophthalmology 2007, 114:995–999.PubMedCrossRefGoogle Scholar
  23. 23.
    Hafner R, Vogel P: Sarcoidosis of early onset. A challenge for the paediatric rheumatologist. Clin Exp Rheumatol 1993, 11:685–691.PubMedGoogle Scholar
  24. 24.
    Holland GN, Stiehm ER: Special considerations in the evaluation and management of uveitis in children. Am J Opthalmol 2003, 135:867–878.CrossRefGoogle Scholar
  25. 25.
    Pandrea A, Rudinskaya A, Klein B, et al.: What does it take to diagnose Behçet’s disease? J Clin Rheumatol 2007, 13:31–34.PubMedCrossRefGoogle Scholar
  26. 26.
    Bonfioli AA, Orefice F: Behçet’s disease. Semin Ophthalmol 2005, 20:199–206.PubMedCrossRefGoogle Scholar
  27. 27.
    Kurokawa MS, Suzuki N: Behçet’s disease. Clin Exp Med 2004, 3:10–20.CrossRefGoogle Scholar
  28. 28.
    Damico FM, Kiss S, Young LH: Vogt-Koyanagi-Harada disease. Semin Ophthalmol 2005, 20:183–190.PubMedCrossRefGoogle Scholar
  29. 29.
    Read RW, Holland GN, Rao NA, et al.: Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001, 131:647–652.PubMedCrossRefGoogle Scholar
  30. 30.
    Mantovani A, Resta A, Herbort C, et al.: Work-up, diagnosis and management of acute Vogt-Koyanagi-Harada disease. Int Ophthalmol 2007, 27:105–115.PubMedCrossRefGoogle Scholar
  31. 31.
    Ohno S, Char DH, Kimura SJ, et al.: Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol 1977, 83:735–740.PubMedGoogle Scholar
  32. 32.
    Sugiura S: Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 1978, 22:9–35.Google Scholar
  33. 33.
    Yamaki K, Hara K, Sakuragi S: Application of revised diagnostic criteria for Vogt-Koyanagi-Harada disease in Japanese patients. Jpn J Ophthalmol 2005, 49:143–148.PubMedCrossRefGoogle Scholar
  34. 34.
    Miyanaga M, Kawaguchi T, Shimizu K, et al.: Influence of early cerebrospinal fluid-guided diagnosis and early high-dose corticosteroid therapy on ocular outcomes of Vogt-Koyanagi-Harada disease. Int Ophthalmol 2007, 27:183–188.PubMedCrossRefGoogle Scholar
  35. 35.
    Shah KH, Levinson RD, Yu F, et al.: Birdshot chorioretinopathy. Surv Ophthalmol 2005, 50:519–541.PubMedCrossRefGoogle Scholar
  36. 36.
    Zein G, Berta A, Foster CS: Multiple sclerosis-associated uveitis. Ocul Immunol Inflamm 2004, 12:137–142.PubMedCrossRefGoogle Scholar
  37. 37.
    Mochizuki M, Watanebe T, Yamaguchi K, et al.: Human T-lymphotropic virus type 1-associated disease. In Ocular Infection and Immunity. Edited by Pepose JS, Holland GN, Wilhelmus KR. Boston: Mosby; 1996:1366–1387.Google Scholar
  38. 38.
    Bonfioli AA, Eller AW: Acute retinal necrosis. Semin Ophthalmol 2005, 20:155–160.PubMedCrossRefGoogle Scholar
  39. 39.
    Steere AC: Lyme disease. N Engl J Med 2001, 345:115–125.PubMedCrossRefGoogle Scholar
  40. 40.
    Winward KE, Smith JL, Culbertson WW, et al.: Ocular Lyme borreliosis. Am J Ophthalmol 1989, 108:651–657.PubMedGoogle Scholar
  41. 41.
    Winterkorn JMS: Lyme disease: neurologic and ophthalmic manifestations. Surv Ophthalmol 1990, 35:191–204.PubMedCrossRefGoogle Scholar
  42. 42.
    Bonfioli AA, Orefice F: Toxoplasmosis. Semin Ophthalmol 2005, 20:129–141.PubMedCrossRefGoogle Scholar
  43. 43.
    Stewart JM, Cubillan LDP, Cunningham ET: Prevalence, clinical features and causes of vision loss among patients with ocular toxocariasis. Retina 2005, 25:1005–1013.PubMedCrossRefGoogle Scholar
  44. 44.
    Ormerod LD, Dailey JP: Ocular manifestations of cat-scratch disease. Curr Opin Ophthalmol 1999, 10:209–216.PubMedCrossRefGoogle Scholar
  45. 45.
    Sallam A, Lynn W, McCluskey P, et al.: Endogenous Candida endophthalmitis. Expert review of anti-infective therapy 2006, 4:675–685.PubMedCrossRefGoogle Scholar
  46. 46.
    Ng P, McCluskey PJ, McCaughan G, et al.: Ocular complications of heart, lung and liver transplantation. Br J Ophthalmol 1998, 82:423–428.PubMedCrossRefGoogle Scholar
  47. 47.
    Keogh A, Esmore D, Spratt A, et al.: Acetozolamide and cyclosporine. Transplantation 1988, 46:478–479.PubMedCrossRefGoogle Scholar
  48. 48.
    Goldberg DE, Smithen LM, Angelilli A, et al.: HIV-associated retinopathy in the HAART era. Retina 2005, 25:633–649.PubMedCrossRefGoogle Scholar
  49. 49.
    Choi JY, Kafkala C, Foster CS: Primary intraocular lymphoma: a review. Semin Ophthalmol 2006, 21:125–133.PubMedCrossRefGoogle Scholar
  50. 50.
    Rosenthal AR: Ocular manifestations of leukaemia: a review. Ophthalmology 1983, 90:899–905.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.LiverpoolAustralia

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