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Current Allergy and Asthma Reports

, Volume 7, Issue 1, pp 27–32 | Cite as

Etiology of exercise-induced asthma: Physical stress-induced transcription

  • Thomas Hilberg
Article

Abstract

Exercise-induced asthma (EIA) occurs with a high prevalence in both asthmatic and nonasthmatic individuals. Although understanding of the functional genomics (proteomics) in sports medicine remains limited, this review focuses on immunologic changes as reflected in transcriptional regulation in respect to EIA. Studies demonstrated that leukotrienes play a significant role in EIA. Exercise increases the distribution of leukotrienes and influences the leukotriene transcription pathway; it could be shown that the genes ALOX5 and ALOX5AP encoding for 5-lipooxygenase (5-LO) and 5-lipoxygenase—activating protein (FLAP) as well as activators for 5-LO, p38 mitogen-activated protein kinase (MAPK), and others, are enhanced after exercise in healthy subjects. Possibly EIA is triggered via leukotriene release if a predisposition or other conditions (eg, epithelial injury and repair) are present. Furthermore, exercise influences transcription factors such as nuclear factor-kappa B (NF-κB), activator protein-1 (AP1), cytokines, and chemokines and promotes cellular responses linked to EIA, which are possibly able to modify further the incidence or the severity of EIA.

Keywords

Asthma Mast Cell Allergy Clin Immunol Montelukast Respir Crit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Thomas Hilberg
    • 1
  1. 1.Department of Sports MedicineFriedrich-Schiller-University, JenaJenaGermany

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