Current Allergy and Asthma Reports

, Volume 6, Issue 3, pp 203–214 | Cite as

Differential diagnosis of eosinophilic chronic rhinosinusitis

  • John C. Sok
  • Berrylin J. Ferguson


Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflammation. The provisional subcategories of ECRS include superantigen-induced eosinophilic chronic rhinosinusitis, allergic fungal sinusitis, nonallergic fungal eosinophilic chronic rhinosinusitis, and aspirin-exacerbated eosinophilic chronic rhinosinusitis. Within each subcategory, recent findings supporting distinct mechanisms that promote eosinophilic infiltration are presented, and, therefore, targeted therapeutic interventions with specific antibacterial, antifungal, or immune modulation may be indicated.


Eosinophilia Allergy Clin Immunol Nasal Polyp Omalizumab Chronic Rhinosinusitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2006

Authors and Affiliations

  1. 1.Department of OtolaryngologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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