Chemokine networks in atopic dermatitis: traffic signals of disease

  • Andor Pivarcsi
  • Bernhard Homey


Atopic dermatitis is a chronic or chronically relapsing inflammatory skin disease with a prevalence ranging from 10% to 20% in children and 1% to 3% in adults of developed countries. Skin-infiltrating leukocytes play a pivotal role in the initiation and amplification of atopic skin inflammation. Recent studies demonstrated that infiltration of inflammatory cells into tissues is regulated by chemokines. A subset of chemokines including CCL27, CCL17, CCL22, CCL18, CCL11, and CCL13 are highly expressed in atopic dermatitis. The corresponding chemokine receptors are found on the main leukocyte subsets involved in allergic skin inflammation, such as T cells, eosinophils, and dendritic cells. In this article, we provide an overview of the role of chemokines in the complex immunopathogenesis of atopic dermatitis, highlighting potential areas for therapeutic intervention.


Atopic Dermatitis Chemokine Receptor Skin Inflammation Allergy Clin Immunol Inflammatory Skin Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Andor Pivarcsi
    • 1
  • Bernhard Homey
    • 1
  1. 1.Department of DermatologyHeinrich-Heine-UniversityDüsseldorfGermany

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