Role of regulatory dendritic cells in allergy and asthma
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Dendritic cells (DCs) are the most efficient inducers of all immune responses, and are capable of either inducing productive immunity or maintaining the state of tolerance to self antigens and allergens. In this review, we summarize the emerging literature on DCs, with emphasis on the regulatory function of DCs in allergy and asthma. In particular, we summarize recent data regarding the relationship between DC subsets and TH1, TH2, and regulatory T (TReg) cells. The diverse functions of DCs have been attributed to distinct lineages of DCs, which arise from common immature precursor cells that differentiate in response to specific maturationinducing or local microenvironment conditions. These subsets of DCs induce different lineages of T cells, such as TH1, TH2, and TReg cells, including Th1Reg and Th2Reg cells, which regulate allergic diseases and asthma. Subsets of DCs regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing antiinflammatory responses and protective immunity.
KeywordsAsthma Dendritic Cell Costimulatory Molecule Plasmacytoid Dendritic Cell Bronchial Lymph Node
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References and Recommended Reading
- 14.LeibundGut-Landmann S, Waldburger J-M, e Sousa CR, et al.: MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells. 2004, advanced online publication.Google Scholar
- 16.Anderson CF, Lucas M, Gutierrez-Kobeh L, et al.: T cell biasing by activated dendritic cells. J Immunol 2004, 173:955–961.In this report the authors demonstrate that DCs respond to immune complexes by altering their cytokine production such as IL-12p70 to induce a Th2-like cytokine response in T cells. Furthermore, they show the mechanism by which DCs altered their cytokine production in response to immune complexes, which was different from the mechanisms of macrophages.PubMedGoogle Scholar
- 21.Watanabe N, Hanabuchi S, Soumelis V, et al.: Human thymic stromal lymphopoietin promotes dendritic cell mediated CD4+ T cell homeostatic expansion. 2004, 5:426–434.Google Scholar
- 23.Rohn TA, Boes M, Wolters D, et al.: Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization. Nature Immunol 2004, 5:909–918.The authors conclude that the self-peptide CLIP on DCs qualifies as an endogenous regulator in priming of T helper cells by antagonizing the polarization toward the TH1 phenotype.CrossRefGoogle Scholar
- 38.Braun-Fahrlander C, Gassner M, Grize L, et al.: Prevalence of hay fever and allergic sensitization in farmer’s children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 1999, 29:28–34.PubMedCrossRefGoogle Scholar
- 41.Akdis M, Verhagen J, Taylor A, et al.: Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004, 199:1567–75.This work demonstrates that immune response to allergens in health and disease is the result of a balance between allergen-specific Tr1 cells and allergen-specific Th2 cells.PubMedCrossRefGoogle Scholar
- 47.de Heer HJ, Hammad H, Soullie T, et al.: Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004, 200:89–98.In this work, the authors showed that pDCs provide intrinsic protection against inflammatory responses to harmless antigens in lungs.PubMedCrossRefGoogle Scholar
- 50.Stock P, Akbari O, Berry G, et al.: Induction of a TH1-like regulatory cell that expresses Foxp3 and protects against airway hyperreactivity. Nature Immunol 2004, 5:1149–1156.In this work, Stock et al. developed a novel adaptive TReg cell type in vivo that produced both IL-10 and IFN-γ and expressed foxp3 and T-bet.CrossRefGoogle Scholar
- 58.Herman A, Freeman G, Mathis D, Benoist C: CD4+CD25+T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 2004, 199:1479–1489.The authors demonstrated that TRegs in the pancreatic lesion express FoxP3 and produce high levels of IL-10 and inducible costimulator (ICOS). Blockade of ICOS rapidly converts early insulitis to diabetes, which disrupts the balance of Teffs and Tregs and promotes a very broad shift in the expression of the T regulatory-specific profile.PubMedCrossRefGoogle Scholar