Cockroaches produce several potent allergens associated with sensitization and the development of asthma. Many of these allergens have been cloned and produced as biologically active recombinant proteins. Three-dimensional structure and molecular modeling, in addition to studies on the biological functions of these proteins in the cockroach, have provided new insights into the ability of these allergens to cause immunoglobulin E antibody responses. Recent studies have pointed to a potential role of recombinant cockroach allergens for diagnosis and the development of novel therapeutic strategies that may benefit cockroachallergic patients.
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