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Current Allergy and Asthma Reports

, Volume 3, Issue 5, pp 424–429 | Cite as

Environmental control for fungal allergen exposure

  • Peyton A. Eggleston
Article

Abstract

With our limited knowledge of the mold allergens, we must rely on common sense to reduce environmental exposure for patients who are allergic to mold. We understand that the first step is moisture control. Appropriate building design, keeping rainwater and ground water away from the interior, accomplishes this. In addition, the heating ventilation and air conditioning system must be appropriately designed and maintained. Functional maintenance of inside water sources such as free water from plumbing, appliances, and showers can prevent damaging leaks. Indoor humidity or water vapor must be controlled and maintained to prevent condensation on walls or in microenvironments, such as attics, bedrooms, basements, and beneath wall-to-wall carpeting. Few abatement trials have been published, but several suggest that such measures can reduce mold exposure.

Keywords

Allergy Clin Immunol Mold Growth Indoor Allergen Mold Spore Indoor Mold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References and Recommended Reading

  1. 1.
    Institute of Medicine Committee on the Assessment of Asthma and Indoor Air: Indoor dampness and asthma. In Clearing the Air: Asthma and Indoor Air Exposures. Washington DC: National Academy Press; 2000:263–297. An excellent assessment of current knowledge regarding the respiratory health effects of indoor dampness and moisture.Google Scholar
  2. 2.
    Brunekreef B, Dockery DW, Spiezer FE, et al.: Home dampness and respiratory morbidity in children. Am Rev Respir Dis 1989, 140:1363–1367.PubMedGoogle Scholar
  3. 3.
    Dales RE, Miller D, McMullen E: Indoor air quality and health: validity and determinants of reported home dampness and moulds. Int J Epidemiol 1997, 26:120–124.PubMedCrossRefGoogle Scholar
  4. 4.
    Gent JF, Ren P, Belager K, et al.: Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environ Health Perspect 2002, 110:A781-A786.PubMedCrossRefGoogle Scholar
  5. 5.
    Pirhonen I, Nevalainen A, Husman T, Pekkanen J: Home dampness, moulds and their influence on respiratory infections and symptoms in adults in Finland. Eur Respir J 1996, 9:2618–2622.PubMedCrossRefGoogle Scholar
  6. 6.
    Solomon WR, Platts-Mills TAE: Aerobiology and inhalant allergens. In Allergy Principles and Practice, edn 5. Edited by Middleton E Jr, Reed CE, Ellis EF, et al. St Louis: Mosby; 1998:367–403.Google Scholar
  7. 7.
    Liu D, Nazaroff WW: Particle penetration through windows. Proc Indoor Air 2002. 2002, 8:862–867.Google Scholar
  8. 8.
    Mosley RB, Greenwell DJ, Sparks LE, et al.: Penetration of ambient fine particles into the indoor environment. Aerosol Sci Technol 2001, 34:127–136.CrossRefGoogle Scholar
  9. 9.
    Garrett MH, Rayment PR, Hoper MA, et al.: Indoor airborne fungal spores, house dampness and associations with environmental factors and respiratory health in children. Clin Exp Allergy 1998, 28:459–467.PubMedCrossRefGoogle Scholar
  10. 10.
    Institute of Medicine Committee on the Health Effects of Indoor Allergens: Engineering control strategies. In Allergens: Assessing and Controlling Adverse Health Effects. Washington, DC: National Academy Press; 1993:206–232.Google Scholar
  11. 11.
    American Thoracic Society Workshop: Achieving healthy indoor air. Am J Resp Crit Care Med 1997, 156(Suppl):44–64. A detailed description of building design and maintenance to prevent indoor dampness problems, with all appropriate references to documents.Google Scholar
  12. 12.
    Gravesen S, Nielsen P, Iversen R, Nielsen K: Microfungal contamination of damp buildings: examples of risk constructions and risk materials. Environ Health Perspect 1999, 107(Suppl3):505–508.PubMedGoogle Scholar
  13. 13.
    Halonen M, Stern DA, Wright AL, et al.: Alternaria as a major allergen for asthma in children raised in a desert environment. Am J Respir Crit Care Med 1997, 155:1356–1361.PubMedGoogle Scholar
  14. 14.
    Wood RA, Eggleston PA, Lind P, et al.: Antigenic analysis of household dust samples. Am Rev Respir Dis 1988, 137:358–363.PubMedGoogle Scholar
  15. 15.
    Douwes J, van der Sluis B, Doekes G, et al.: Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: relations with culturable fungi, reported home dampness, and respiratory symptoms. J Allergy Clin Immunol 1999, 103:494–500.PubMedCrossRefGoogle Scholar
  16. 16.
    Wickman M, Gravesen S, Nordvall L, et al.: Indoor viable dustbound microfungi in relation to residential characteristics, living habits, and symptoms in atopic and control children. J Allergy Clin Immunol 1992, 89:752–759.PubMedCrossRefGoogle Scholar
  17. 17.
    Dharmage S, Bailey M, Raven J, et al.: Prevalence and residential determinants of fungi within homes in Melbourne, Australia. Clin Exp Allergy 1999, 29:1481–1489.PubMedCrossRefGoogle Scholar
  18. 18.
    Burge HA, Solomon WR, Boise JR: An appraisal of impregnon as a deterrent of domestic fungus growth. J Allergy Clin Immunol 1976, 58:491–499.PubMedCrossRefGoogle Scholar
  19. 19.
    Garrison RA, Robertson LD, Koehn RD, Wynn SR: Effect of heating-ventilation-air conditioning system sanitation on airborne fungal populations in residential environments. Ann Allergy 1994, 71:548–556.Google Scholar
  20. 20.
    Kuhn DM, Ghannoun MA: Indoor mold, toxigenic fungi and Stachybotrys chartarum: infectious disease perspective. Clin Microbiol Rev 2003, 16:144–172. This is the definitive reference on the infectious and toxic effects of mold. It is extensively referenced and deals with the very important issue of toxigenic mold. This aspect of mold biology is well publicized, and this paper provides a clear and thoughtful assessment of the evidence.PubMedCrossRefGoogle Scholar
  21. 21.
    Von Essen S, Robbins RA, Thompson AB, Rennard SI: Organic dust toxic syndrome: an acute febrile reaction to organic dust exposure distinct from hypersensitivity pneumonitis. J Toxicol Clin Toxicol 1990, 28:389–342.CrossRefGoogle Scholar
  22. 22.
    Etzel RA, Montana E, Sorenson WG, et al.: Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 1998, 152:757–762.PubMedGoogle Scholar
  23. 23.
    Richerson HP: Unifying concepts underlying the effect of organic dusts exposure. Am J Ind Med 1990, 17:139–142.PubMedGoogle Scholar
  24. 24.
    Environmental Protection Agency: Clear your home of asthma triggers. No 402-F-99-005. Washington, DC: EPA; 1999.Google Scholar
  25. 25.
    Savilahti R, Uitti J, Laippala P, et al.: Respiratory morbidity among children following renovation of a water-damaged school. Arch Environ Health 2000, 55:405–410.PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Peyton A. Eggleston
    • 1
  1. 1.Department of PediatricsJohns Hopkins University School of Medicine CMSC 1102, Johns Hopkins HospitalBaltimoreUSA

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