Current Allergy and Asthma Reports

, Volume 3, Issue 5, pp 396–401

Immune deficiencies due to defects in cytokine signaling

  • John Kelly
  • Warren J. Leonard

DOI: 10.1007/s11882-003-0073-y

Cite this article as:
Kelly, J. & Leonard, W.J. Curr Allergy Asthma Rep (2003) 3: 396. doi:10.1007/s11882-003-0073-y


Severe combined immunodeficiency (SCID) represents a syndrome comprising the most severe forms of inherited immunodeficiencies. Defects in cytokine signaling pathways can result in impaired development of lymphoid cells and/or defective functioning of these cells, and most cases of SCID result from defective signaling through the common cytokine receptor γ chain (γc) or associated molecules and signaling pathways. Studies of these patients and the analysis of genetargeted mice provide insight into the underlying signaling defects in inherited immunodeficiencies. The identification of the genetic defects in humans with SCID provides the basis for future therapies for these patients. More subtle deficiencies in cytokine signaling have also been found as causes of other forms of immunodeficiency, and the knowledge learned could lead to novel approaches to antimicrobial therapy.

Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • John Kelly
    • 1
  • Warren J. Leonard
    • 1
  1. 1.Laboratory of Molecular ImmunologyNational Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaUSA

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