Current Allergy and Asthma Reports

, Volume 2, Issue 1, pp 63–66 | Cite as

How much food is too much? threshold doses for allergenic foods

  • Susan L. Hefle
  • Steve L. Taylor
Article

Abstract

This review summarizes recent findings and controversies in the area of threshold doses for allergenic foods. Over the years, there have been many clinical reports that ingestion of small amounts of food can elicit IgE-mediated allergic reactions. In exquisitely allergic individuals, the threshold dose for elicitation of such reactions is often considered to be zero. However, some food-allergic patients report that they can tolerate small quantities of allergenic food. Are very low quantities hazardous to foodallergic consumers? How much of the offending food is too much? Why is the concept of a threshold level important? There have been very few studies to date on threshold doses for allergenic foods, and more research is needed in this important area.

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References and Recommended Reading

  1. 1.
    Bock SA, Munoz-Furlong A, Sampson HA: Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2000, 107:191–193. An in-depth look at 32 cases of fatalities due to foods and the surrounding circumstances.CrossRefGoogle Scholar
  2. 2.
    Huggett AC, Hischenhuber C: Food manufacturing initiatives to protect the allergic consumer. Allergy 1998, 53(suppl 46):89–92.PubMedCrossRefGoogle Scholar
  3. 3.
    Yunginger JW, Sweeney KG, Sturner WQ, et al.: Fatal foodinduced anaphylaxis. JAMA 1988, 260:1450–1452.PubMedCrossRefGoogle Scholar
  4. 4.
    Sampson HA, Mendelson L, Rosen JP: Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992, 327:380–384.PubMedCrossRefGoogle Scholar
  5. 5.
    Hourihane, JO: The threshold concept in food safety and its applicability to food allergy. Allergy 2001, 67:86–90. An opinion paper outlining some of the questions and considerations surrounding threshold studies by one of the first investigators to address threshold issues.CrossRefGoogle Scholar
  6. 6.
    Hourihane JO, Kilburn SA, Nordlee JA, et al.: An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study. J Allergy Clin Immunol 1997, 100:596–600.CrossRefGoogle Scholar
  7. 7.
    Rance F, Abbal M, Dutau G: Peanut allergy in children: skin prick test, specific IgE and dose response by double-blind placebo-controlled food challenge [abstract]. Allergy 2000, 55(suppl 63):55.Google Scholar
  8. 8.
    Hansen TK, Bindslev-Jensen C: Codfish allergy in adults. Identification and diagnosis. Allergy 1992, 47:610–617.PubMedCrossRefGoogle Scholar
  9. 9.
    Christie L, Burks AW, Althage K, et al.: Threshold dose for egg allergy determined by oral challenge [abstract]. J Allergy Clin Immunol 2001, 107:S231.Google Scholar
  10. 10.
    Sicherer SH, Munoz-Furlong A, Burks AW, et al.: Prevalence of peanut and tree nut allergy in the US determined by a random digit dial telephone survey. J Allergy Clin Immunol 1999, 103:559–562.PubMedCrossRefGoogle Scholar
  11. 11.
    Laoprasert N, Wallen ND, Jones RT, et al.: Anaphylaxis in a milk-allergic child following ingestion of milk-contaminated lemon sorbet. J Food Prot 1998, 61:1522–1524.PubMedGoogle Scholar
  12. 12.
    Hefle SL: Hidden food allergens. Curr Opin Allergy Clin Immunol 2001, 1:269–271. A review of recent findings in the area of hidden food allergens.PubMedGoogle Scholar

Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • Susan L. Hefle
    • 1
  • Steve L. Taylor
    • 1
  1. 1.Food Allergy Research and Resource ProgramUniversity of NebraskaLincolnUSA

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