Allergenic components of vaccines and avoidance of vaccination-related adverse events
Vaccines have had a dramatic effect on the prevalence of communicable diseases, but, in selected individuals, the injection presents a risk of anaphylaxis. Fortunately, most people have no allergic reactions to vaccines. In egg-allergic individuals, care must be taken before administering specific vaccines; the algorithm provided in this article gives specific recommendations for skin testing and desensitization. This algorithm is not needed for individuals receiving the measles-mumps-rubella vaccine because the risk of anaphylaxis is extremely low, even in those with known egg-protein sensitivity. Some individuals have gelatin sensitivity, which may cause anaphylaxis. Selected vaccines contain antibiotic drugs, so it is important to note if an individual has any known drug sensitivity, especially to neomycin, polymyxin B, or amphotericin B. Lastly, vaccine preservatives may cause reactions, but this occurs very infrequently.
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References and Recommended Reading
- 1.American Academy of Pediatrics: Report of the Committee on Infectious Diseases. In Red Book, edn 25. Edited by Pickering LK. Elk Grove Village: American Academy of Pediatrics; 2000:1–82.Google Scholar
- 2.Physicians’ Desk Reference, edn 54. Montvale: Medical Economics; 2000.Google Scholar
- 3.Zimmerman B, Zimmerman RS: Adverse reactions to vaccines. In Allergy: Principles and Practice, edn 5. Edited by Middleton EM Jr, Reed CE, Ellis EF, et al. St. Louis: Mosby; 1998:1199–1211.Google Scholar
- 15.Nakayama T, Aizawa C, Kuno-Sakai H: A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allergy Clin Immunol 1999, 103:321–325.PubMedCrossRefGoogle Scholar