Effects of inhaled corticosteroids on growth in asthmatic children
- 42 Downloads
This article presents a brief review of the effects of inhaled corticosteroids on growth in children with asthma. All currently available inhaled corticosteroids, where there is adequate data, have been shown to cause significant growth suppression in children in a dose-dependent manner. It is now apparent that there are differences in the growthsuppressive effects of different corticosteroids. Recent evidence confirms that the growth-suppressive effects are short lived and that, at conventional doses, inhaled corticosteroids do not affect final attained adult height.
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 9.The Childhood Asthma Management Program Research Group: Long term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000, 343:1054–1063. This 4- to 6-year comparison of BUD, nedocromil, and placebo demonstrated that growth while receiving budesonide is decreased in the 1st year but normal thereafter.CrossRefGoogle Scholar
- 10.Cohen MB, Welles RR, Cohen S: Anthropometry in children: progress in allergic children as shown by increments in height, weight and maturity. Am J Dis Child 1940, 60:1058–1066.Google Scholar
- 26.MacKenzie CA, Wales JK: Growth of asthmatic children. BMJ 1991, 303:416.Google Scholar
- 31.Doull IJM, Campbell MJ, Holgate ST: Duration of growth suppressive effects of regular inhaled corticosteroids. Arch Dis Child 1997, 78:172–173.Google Scholar
- 33.Rao R, Gregson RK, Jones AC, et al.: Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone and beclomethasone. Eur Respir J 1990, 13:87–94.Google Scholar
- 34.Agertoft L, Pedersen S: Effect of long term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 2000, 343:1064–1069. In this longitudinal follow-up of over 300 children, BUD caused decreased growth when initiated, but there were no long-term effects on growth, and attained adult height was normal.PubMedCrossRefGoogle Scholar