Current Allergy and Asthma Reports

, Volume 1, Issue 6, pp 566–571 | Cite as

The diagnosis and treatment of whipple’s disease

  • Thomas Marth


Whipple’s disease is a rare, chronic, and systemic infectious disease caused by the ubiquitously occuring bacterium Tropheryma whippelii. For two reasons, the disease represents a good example for documenting the input of modern molecular-based techniques into pathogenetic, diagnostic, and therapeutic concepts in clinical medicine. First, the unidentified and uncultivable causative organism has been characterized by novel molecular-genetic techniques. Second, in contrast to other chronic inflammatory disorders, clinical manifestations of T. whippelii infection seem to be based on reduced T-cell helper type 1 (TH1) activity. These findings have led to an improved pathophysiologic understanding of the disease and to new aspects in treatment strategies that are discussed in this paper.


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Copyright information

© Current Science Inc. 2001

Authors and Affiliations

  • Thomas Marth
    • 1
  1. 1.Deutsche Klinik für DiagnostikWiesbadenGermany

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