Annals of Dyslexia

, Volume 61, Issue 1, pp 1–20 | Cite as

Multivariate predictive model for dyslexia diagnosis

  • Guylaine Le Jan
  • Régine Le Bouquin-Jeannès
  • Nathalie Costet
  • Nolwenn Trolès
  • Pascal Scalart
  • Dominique Pichancourt
  • Gérard Faucon
  • Jean-Emile Gombert


Dyslexia is a specific disorder of language development that mainly affects reading. Etiological researches have led to multiple hypotheses which induced various diagnosis methods and rehabilitation treatments so that many different tests are used by practitioners to identify dyslexia symptoms. Our purpose is to determine a subset of the most efficient ones by integrating them into a multivariate predictive model. A set of screening tasks that are the most commonly used and representative of the different cognitive aspects of dyslexia was proposed to 78 children from elementary school (mean age = 9 years ± 7 months) exempt from identified reading difficulties and to 35 dyslexic children attending a specialized consultation for dyslexia. We proposed a multi-step procedure: within each category, we first selected the most representative tasks using principal component analysis and then we implemented logistic regression models on the preselected variables. Spelling and reading tasks were considered separately. The model with the best predictive performance includes eight variables from four categories of tasks and classifies correctly 94% of the children. The sensitivity (91%) and the specificity (95%) are both high. Forty minutes are necessary to complete the test.


Diagnosis Dyslexia Logistic regression Multivariate analysis Predictive model 


  1. Ans, B., Carbonnel, S., & Valdois, S. (1998). A connectionist multi-trace memory model of polysyllabic word reading. Psychological Review, 105, 678–723.CrossRefGoogle Scholar
  2. Beauvois, M. F., & Derouesné, J. (1979). Phonological alexia: Three dissociations. Journal of Neurology, 42, 1115–1124.Google Scholar
  3. Billard, C., Gillet, P., Galloux, A., Piller, A. G., Livet, M. O., Motte, J., et al. (2000). BREV: une batterie clinique de dépistage des déficits cognitifs chez l’enfant de 4 à 9 ans. Résultats de l’étude normative chez 500 enfants. Archives Françaises de Pédiatrie, 7, 128s–130s.CrossRefGoogle Scholar
  4. Casalis, S. (1995). Lecture et dyslexies de l’enfant. Paris: Septentrion.Google Scholar
  5. Casalis, S. (2003). The delay-type in developmental dyslexia: Reading processes. Current Psychology Letters: Behavior, Brain and Cognition, 10.Google Scholar
  6. Casalis, S., Colé, P., & Sopo, D. (2004). Morphological awareness in developmental dyslexia. Annals of Dyslexia, 54(1), 114–138.CrossRefGoogle Scholar
  7. Chevrier-Muller, C., & Plaza, M. (2001). Nouvelles épreuves pour l’Examen du Langage. Edition du Centre de Psychologie Appliquée (ECPA).Google Scholar
  8. Chevrier-Muller, C., Simon, A. M., & Fournier, F. (1997). Batterie Langage Oral, Langage Ecrit, Mémoire. Edition du Centre de Psychologie Appliquée (ECPA): Attention.Google Scholar
  9. Cohen, M. J. (2001). Echelle de Mémoire pour Enfants. ECPA.Google Scholar
  10. Colé, P., Marec-Breton, N., Royer, C., & Gombert, J. E. (2003). Morphologie des mots et apprentissage de la lecture. Rééducation Orthophonique, 213, 57–76.Google Scholar
  11. Coltheart, M., Mastersin, J., Bying, S., Prior, M., & Riddoch, J. (1983). Surface dyslexia. Quartely Journal of Experimental Psychology, 35, 469–595.Google Scholar
  12. Denckla, M. B., & Rudel, R. (1976). Rapid automatized naming (RAN): Dyslexia differentiated from other learning disabilities. Neuropsychologia, 14, 471–479.CrossRefGoogle Scholar
  13. Duffi, F. H., Valencia, I., Mcanulty, G. B., & Waber, D. P. (2001). Auditory evoked response data reduction by PCA: Development of variables sensitive to reading disability. ECNS, Pewaukee, 32(3), 168–178.Google Scholar
  14. Fawcett, A., Nicolson, R., & Dean, O. (1996). Impaired performance of children with dyslexia on a range of cerebellar tasks. Annals of Dyslexia, 46, 259–283.CrossRefGoogle Scholar
  15. Gombert, J. E. (2003). Implicit and explicit learning to read: implication as for subtypes of dyslexia. Current Psychology Letters, 10(1).Google Scholar
  16. Grainger, J., Bouttevin, S., Truc, C., Bastien, M., & Ziegler, J. (2003). Word superiority, pseudoword superiority, and learning to read: A comparison of dyslexic and normal readers. Brain and Language, 87, 432–440.CrossRefGoogle Scholar
  17. Hosmer, D. W., & Lemeshow, S. (2000). Applied logistic regression. Wiley.Google Scholar
  18. Iles, J., Walsh, V., & Richardson, A. (2000). Visual search performance in dyslexia. Dyslexia, 6(15), 163–177.CrossRefGoogle Scholar
  19. INSERM, Expertise collective. (2007). Dyslexie, dysorthographie, dyscalculie. Bilan des données scientifiques. Ed. INSERM.Google Scholar
  20. Jollife, I. T. (2002). Principal component analysis. Springer.Google Scholar
  21. Khomsi, A. (2001). Evaluation du Langage Oral. Edition du Centre de Psychologie Appliquée (ECPA).Google Scholar
  22. Korkman, M., Kirk, U., & Kemp, S. (2003). Bilan neuropsychologique de l’enfant. Edition du Centre de Psychologie Appliquée (ECPA).Google Scholar
  23. Laboratoire des Sciences et de l’Education – UMPF. (2005). ODEDYS 2 Outil de DEpistage des DYSlexies (
  24. Le Jan, G., Troles, N., Le Bouquin Jeannès, R., Faucon, G., Gombert, J. E, Scalart, P. et al. (2008). Développement d'une plate-forme logicielle en vue de l'élaboration d'un outil d'aide au diagnostic de la dyslexie. Approche Neuropsychologique des Apprentissages chez l'Enfant (ANAE), 91, mars, 18-22.Google Scholar
  25. Lefavrais, P. (1965). Description, définition et mesure de la dyslexie. Edition E.C.P.A.Google Scholar
  26. Liberman, A. M., Harris, K. S., Hoffman, H. S., & Griffith, B. C. (1957). The discrimination of speech sounds within and across phoneme boundaries. Journal of Experimental Psychology, 54, 358–368.CrossRefGoogle Scholar
  27. Marec-Breton, N., Gombert, J. E., & Colé, P. (2005). Traitements morphologiques lors de la reconnaissance des mots écrits chez des apprenti-lecteurs. L’Année Psychologique, 105, 9–45.CrossRefGoogle Scholar
  28. McPhillips, M., Hepper, P. G., & Mulhern, G. (2000). Effects if replicating primary-reflexes movements on specific reading difficulties in children: A randomised, double blind, controlled trial. Lancet, 94, 537–541.CrossRefGoogle Scholar
  29. Mousty, P., Leybaert, J., Alegria, J., Content, A., & Morais, J. (1994). BELEC: une batterie d'évaluation du langage écrit et ses implications diagnostiques. In J. Grégroire, & B. Piérat (Eds.), Evaluer les troubles de la lecture: les nouveaux modèles théoriques et leurs implications diagnostiques, pp 127-145.Google Scholar
  30. Nicolson, R. I., Fawcett, A. J., & Dean, P. (2001). Dyslexia, development and the cerebellum. Trends in Neuroscience, 24(9), 515–516.CrossRefGoogle Scholar
  31. Plaza, M., Chauvin, D., Lanthier, O., Rigoard, M. T., Roustit, J., Thibault, M. P., et al. (2002). Validation longitudinale d’un outil de dépistage des troubles du langage écrit. Étude d’une cohorte d’enfants dépistés en fin de CP et réévalués en fin de CE1. Glossa, 81, 22–33.Google Scholar
  32. Ramus, F., Rosen, S., Dakin, S. C., Day, B. L., Castellote, J. M., White, S., et al. (2003). Theory of developmental dyslexia: Insights from a multiple case study of dyslexic adults. Brain, 126, 841–865.CrossRefGoogle Scholar
  33. Reynolds, D., Nicolson, R. I., & Hambly, H. (2003). Evaluation on exercise-based treatment for children with reading difficulties. Dyslexia, 9, 48–71.CrossRefGoogle Scholar
  34. Serniclaes, W., & Sprenger-Charolles, L. (2003). Categorical perception of speech sounds and dyslexia. Special issue on language disorders and reading acquisition, 1.Google Scholar
  35. Serniclaes, W., Sprenger-Charolles, L., Carré, R., & Démonet, J. F. (2001). Perceptual discrimination of speech sounds in dyslexia. Journal of Speech, Language, and Hearing Research, 44, 384–399.CrossRefGoogle Scholar
  36. Snowling, M. J. (2000). Dyslexia. Oxford: Blackwell.Google Scholar
  37. Sprenger-Charolles, L., Cole, P., Larcet, P., & Serniclaes, W. (2000). On subtypes of developmental dyslexia: evidence from processing time and accuracy scores. Canadian Journal of Experimental Psychology, 54, 88–104.Google Scholar
  38. Stein, J., & Fawler, M. S. (1985). Effect of mononuclear occlusion on visuomotor perception and reading in dyslexic children. Lancet., 2, 69–73.CrossRefGoogle Scholar
  39. Stein, J., Richardson, A. J., & Fowler, M. S. (2000). Monocular occlusion can improve binocular control and reading in dyslexics. Brain, 123, 164–170.CrossRefGoogle Scholar
  40. Steyerberg, E. W., Eijkemans, M. J. C., & Habbema, D. F. (1999). Stepwise selection in small data sets: a simulation study of bias in logistic regression analysis. Journal of Clinical Epidemiology, 52, 935–942.CrossRefGoogle Scholar
  41. Steyerberg, E. W., Eijkemans, M. J. C., Harrel, F. E., Jr., & Habbema, D. F. (2000). Prognostic modeling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. Statistics in Medicine, 19, 1059–1079.CrossRefGoogle Scholar
  42. Swets, J. A. (1988). Measuring the accuracy of diagnostic systems. Science, 240, 1285–1293.CrossRefGoogle Scholar
  43. Tallal, P. (1980). Auditory temporal perception, phonics, and reading disabilities in children. Brain Language, 9, 182–198.CrossRefGoogle Scholar
  44. Tallal, P., Miller, S., & Fitch, R. H. (1993). Neurobiological basis of speech: A case for the preeminence of temporal processing. Annals of New York of Academy of Sciences, 682, 27–47.CrossRefGoogle Scholar
  45. Valdois, S., Bosse, M. L., Ans, B., Carbonnel, S., Zorman, M., David, D., et al. (2003). Phonological and visual processing deficits can dissociate in developmental dyslexia: Evidence from two case studies. Reading and Writing: an Interdisciplinary Journal, 16, 541–572.CrossRefGoogle Scholar
  46. Valdois, S., Bosse, M. L., & Tainturier, M. J. (2004). The cognitive deficits responsible for developmental dyslexia: Review of evidence for a selective visual attentional disorder. Dyslexia, 10, 1–25.CrossRefGoogle Scholar
  47. Wechsler, D. (1991). Manual du WISC-III, échelle d’intelligence de Wechsler pour enfant (3rd ed.). Paris: Edition du Centre de Psychologie Appliquée (ECPA).Google Scholar
  48. White, S., Milne, E., Rosen, S., Hansen, P., Swettenham, J., Frith, U., et al. (2006). The role of sensorimotor impairments in dyslexia: A multiple case study of dyslexic children. Developmental science, 9(3), 237–255.CrossRefGoogle Scholar
  49. Wolf, M., & Bowers, P. (1999). The question of naming speeds deficit in developmental reading disabilities: An introduction to the double-deficit hypothesis. Journal of Educational Psychology, 19, 1–24.Google Scholar

Copyright information

© The International Dyslexia Association 2010

Authors and Affiliations

  • Guylaine Le Jan
    • 1
    • 2
  • Régine Le Bouquin-Jeannès
    • 1
    • 2
  • Nathalie Costet
    • 1
    • 2
  • Nolwenn Trolès
    • 3
  • Pascal Scalart
    • 4
  • Dominique Pichancourt
    • 5
  • Gérard Faucon
    • 1
    • 2
  • Jean-Emile Gombert
    • 3
  1. 1.INSERM, U 642RennesFrance
  2. 2.Université de Rennes 1, LTSIRennesFrance
  3. 3.Université de Rennes 2CRPCCRennesFrance
  4. 4.IRISA/ENSSATLannion CedexFrance
  5. 5.Service MPR Pédiatrique du Centre Hospitalier Lannion-TrestelTrévou-TréguignecFrance

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