Air Quality, Atmosphere & Health

, Volume 6, Issue 2, pp 455–463 | Cite as

Prenatal ambient air pollution exposure and small for gestational age birth in the Puget Sound Air Basin

  • Sheela Sathyanarayana
  • Chuan Zhou
  • Carole B. Rudra
  • Tim Gould
  • Tim Larson
  • Jane Koenig
  • Catherine J. Karr
Article

Abstract

Several studies have identified high concentrations of air pollution as harmful to the developing fetus, but few studies of traffic-derived air pollution and birth outcomes have been conducted in areas of low to moderate air pollution. We identified singleton live births between 1997 and 2005 (N = 367,046 births) in the Puget Sound Air Basin of Washington State. We estimated nitrogen dioxide (NO2) exposure using a land use regression model of traffic, PM2.5 exposure from the nearest community monitor, and proximity to highways/roadways for the residential location of all subjects. Logistic regression estimates of odds ratios (OR) of small for gestational age (SGA) and low birth weight (<2,500 g) among term births were calculated. We observed a modest association between SGA births with increasing quartile of first trimester NO2 exposure: second (OR = 1.01, 95 % confidence interval (CI) 0.97, 1.04), third (OR = 1.06, 95 % CI 1.03, 1.10), and fourth (OR = 1.08, 95 % CI 1.04, 1.12) (p trend <0.001). We did not observe an association between PM2.5 and SGA or low birth weight among term births. Our findings suggest that prenatal exposure to traffic-derived air pollutants has a modest effect on fetal growth in a region with low overall air pollutant concentrations. Given the modest associations, future studies in similar settings that maximize the opportunity to address potential residual confounding are needed.

Keywords

Air pollution Small for gestational age Low birth weight Traffic 

Abbreviations

BMI

Body mass index

CI

Confidence interval

g

Gram

LUR

Land use regression

m

Meters

μg/m3

Micrograms per cubic meter

NO

Nitric oxide

NO2

Nitrogen dioxide

PM2.5

Particulate matter ≤2.5 μm in aerodynamic diameter

OR

Odds ratio

ppb

Parts per billion

SD

Standard deviation

SGA

Small for gestational age

US

United States

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Sheela Sathyanarayana
    • 1
    • 2
    • 5
  • Chuan Zhou
    • 2
  • Carole B. Rudra
    • 3
  • Tim Gould
    • 4
  • Tim Larson
    • 4
    • 5
  • Jane Koenig
    • 5
  • Catherine J. Karr
    • 1
    • 5
  1. 1.Department of PediatricsUniversity of WashingtonSeattleUSA
  2. 2.Center for Child Health, Behavior and DevelopmentSeattle Children’s Research InstituteSeattleUSA
  3. 3.Independent HealthBuffaloUSA
  4. 4.Civil and Environmental EngineeringUniversity of WashingtonSeattleUSA
  5. 5.Department of Environmental and Occupational Health SciencesUniversity of WashingtonSeattleUSA

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