Air Quality, Atmosphere & Health

, Volume 5, Issue 2, pp 151–167 | Cite as

Air pollutants and sources associated with health effects

  • Alberto Ayala
  • Michael Brauer
  • Joe L. Mauderly
  • Jonathan M. Samet
Article
First Online:
Received:
Accepted:

Abstract

This paper provides four complementary perspectives on the understanding of the risk posed to health by particular sources of air pollution. These perspectives are based on contributions to a plenary session "Pollutants and Sources Associated with Health Effects" at the American Association for Aerosol Research meeting. Research that advanced understanding of source impacts is critical to the prospects for more refined air quality management that moves from the pollutant-oriented approaches in place for the "criteria pollutants" to more targeted strategies. Such research will also be needed in support of multipollutant air quality management strategies. Here, after beginning with a discussion of mobile sources (Ayala), we provide brief historical summaries of relevant research and future research directions framed around the core scientific research disciplines: exposure sciences (Brauer), toxicology (Mauderly) and epidemiology (Samet). Overall, we find that the overarching most important need is to "put the regulatory cart behind the research horse", in the sense that the focus of research, funding permitting, should not be limited to supporting existing air quality regulations. We suggest that more informative research can be carried out using increasingly sophisticated tools and drawing on advancing biological knowledge. However, these tools need to be used and managed in an appropriate framework.

Keywords

Exposure sciences Toxicology Epidemiology Multipollutant air quality management 
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References

  1. Allen RW, Carlsten C, Karlen B, Leckie S, van Eeden S, Vedal S, Wong I, Brauer M (2011) An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med 183:1222–1230CrossRefGoogle Scholar
  2. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE (2008) Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102(5):589–596CrossRefGoogle Scholar
  3. Bagley ST, Baumgard KJ, Gratz LD, Johnson JJ, Leddy DG (1996) Characterization of fuel and after-treatment device effects on diesel emissions. Res Rep Health Eff Inst 76:1–75, Discussion 77–86Google Scholar
  4. Ballester F, Medina S, Boldo E, Goodman P, Neuberger M, Iniguez C, Kunzli N (2008) Reducing ambient levels of fine particulates could substantially improve health: a mortality impact assessment for 26 European cities. J Epidemiol Community Health 62(2):98–105CrossRefGoogle Scholar
  5. Barn P, Larson T, Noullett M, Kennedy S, Copes R, Brauer M (2008) Infiltration of forest fire and residential wood smoke: an evaluation of air cleaner effectiveness. J Expo Sci Environ Epidemiol 18(5):503–511CrossRefGoogle Scholar
  6. Barregard L, Sallsten G, Gustafson P, Andersson L, Johansson L, Basu S, Stigendal L (2006) Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation. Inhal Toxicol 18(11):845–853CrossRefGoogle Scholar
  7. Barrett SR, Britter RE, Waitz IA (2010) Global mortality attributable to aircraft cruise emissions. Environ Sci Technol 44(19):7736–7742CrossRefGoogle Scholar
  8. Bedsworth LW, Taylor MR (2007) Learning from California's zero-emission vehicle program. In: Hanak E (ed) California Economic Policy. Public Policy Institute of California, San Francisco, 3Google Scholar
  9. Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP (2010) Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources. Epidemiology 21(6):884–891CrossRefGoogle Scholar
  10. Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM (2007) Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies. Environ Heal Perspect 115(7):989–995CrossRefGoogle Scholar
  11. Bell ML, Ebisu K, Peng RD, Samet JM, Dominici F (2009) Hospital admissions and chemical composition of fine particle air pollution. Am J Respir Crit Care Med 179(12):1115–1120CrossRefGoogle Scholar
  12. Bell ML, Levy JK, Lin Z (2008) The effect of sandstorms and air pollution on cause-specific hospital admissions in Taipei, Taiwan. Occup Environ Med 65(2):104–111CrossRefGoogle Scholar
  13. Bell ML, Samet JM, Dominici F (2004) Time-series studies of particulate matter. Annu Rev Public Health 25:247–280CrossRefGoogle Scholar
  14. Bennett DH, McKone TE, Evans JS, Nazaroff WW, Margni MD, Jolliet O, Smith KR (2002) Defining intake fraction. Environ Sci Technol 36(9):207A–211ACrossRefGoogle Scholar
  15. Biswas P, Wu CY (2005) 2005 Critical review: nanoparticles and the environment. J Air Waste Manag Assoc 55(6):708–746Google Scholar
  16. Biswas S, Hu SH, Verma V, Herner JD, Robertson WH, Ayala A, Sioutas C (2008) Physical properties of particulate matter (PM) from late model heavy-duty diesel vehicles operating with advanced PM and NOx emission control technologies. Atmos Environ 42(22):5622–5634CrossRefGoogle Scholar
  17. Boldo E, Linares C, Lumbreras J, Borge R, Narros A, Garcia-Perez J, Fernandez-Navarro P, Perez-Gomez B, Aragones N, Ramis R, Pollan M, Moreno T, Karanasiou A, Lopez-Abente G (2010) Health impact assessment of a reduction in ambient PM(2.5) levels in Spain. Environ Int 37(2):342–348CrossRefGoogle Scholar
  18. Bond GS (1910) Effect of various agents on the blood flow through the coronary arteries and veins. J Exp Med 12(5):575–585CrossRefGoogle Scholar
  19. Brauner EV, Forchhammer L, Moller P, Barregard L, Gunnarsen L, Afshari A, Wahlin P, Glasius M, Dragsted LO, Basu S, Raaschou-Nielsen O, Loft S (2008) Indoor particles affect vascular function in the aged: an air filtration-based intervention study. Am J Respir Crit Care Med 177(4):419–425CrossRefGoogle Scholar
  20. Burtscher H (2005) Physical characterization of particulate emissions from diesel engines: a review. J Aerosol Sci 36(7):896–932CrossRefGoogle Scholar
  21. Cakmak S, Dales RE, Vida CB (2009) Components of particulate air pollution and mortality in Chile. Int J Occup Environ Health 15(2):152–158Google Scholar
  22. Cackette T (2010) Reducing vehicle emissions to meet environmental goals. Proceedings of the Coordinating Research Council 20th on-road vehicle emissions workshop, San Diego, CA. March 22–24, 2010Google Scholar
  23. California Air Resources Board (2010) California greenhouse gas emission inventory. Available via http://www.arb.ca.gov/cc/inventory/inventory.htm. Accessed 28 Jan 2011.
  24. Clancy L, Goodman P, Sinclair H, Dockery DW (2002) Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 360(9341):1210–1214CrossRefGoogle Scholar
  25. Corbett JJ, Winebrake JJ, Green EH, Kasibhatla P, Eyring V, Lauer A (2007) Mortality from ship emissions: a global assessment. Environ Sci Technol 41(24):8512–8518CrossRefGoogle Scholar
  26. de Bruijne K, Sexton KG, Ebersviller S, Olenick C, Woodside R, Doyle-Eisele M, Jeffries H and Jaspers I (2008) Comparing the toxicity of fresh and aged diesel exhaust using a newly developed in vitro exposure system. Platform paper presented at 27th American Association of Aerosol Research Annual Conference, OrlandoGoogle Scholar
  27. Deane M, Goldsmith JR, Tuma D (1965) Respiratory conditions in outside workers. Report on outside plant telephone workers in San Francisco and Los Angeles. Arch Environ Health 10:323–331Google Scholar
  28. Dockery DW, Cunningham J, Damokosh AI, Neas LM, Spengler JD, Koutrakis P, Ware JH, Raizenne M, Speizer FE (1996) Health effects of acid aerosols on North American children: respiratory symptoms. Environ Heal Perspect 104(5):500–505CrossRefGoogle Scholar
  29. Doll R, Hill AB (1950) Smoking and carcinoma of the lung. British Med J 2(4681):739–748CrossRefGoogle Scholar
  30. Doll R, Hill AB (1952) A study of the aetiology of carcinoma of the lung. British Med J 2(4797):1271–1286CrossRefGoogle Scholar
  31. Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML (2007) Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environ Health Perspect 115(12):1701–1703CrossRefGoogle Scholar
  32. Ebelt ST, Wilson WE, Brauer M (2005) Exposure to ambient and nonambient components of particulate matter: a comparison of health effects. Epidemiology 16(3):396–405CrossRefGoogle Scholar
  33. Ferris BG Jr, Higgins IT, Higgins MW, Peters JM, Van GWF, Goldman MD (1971) Chronic nonspecific respiratory disease, Berlin, New Hampshire, 1961–1967: a cross-sectional study. Am Rev Respir Dis 104(2):232–244Google Scholar
  34. Ferris BG Jr, Speizer FE, Spengler JD, Dockery DW, Bishop YM, Wolfson M, Humble C (1979) Effects of sulfur oxides and respirable particles on human health: methodology and demography of populations in study. Am Rev Respir Dis 120:767–779Google Scholar
  35. Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J (2007) Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet 369(9561):571–577CrossRefGoogle Scholar
  36. Giles LV, Barn P, Kunzli N, Romieu I, Mittleman MA, van Eeden S, Allen R, Carlsten C, Stieb D, Noonan C, Smargiassi A, Kaufman JD, Hajat S, Kosatsky T, Brauer M (2010) From good intentions to proven interventions: effectiveness of actions to reduce the health impacts of air pollution. Environ Health Perspect 119(1):29–36CrossRefGoogle Scholar
  37. Giles LV, Barn P, Kunzli N, Romieu I, Mittleman MA, van Eeden S, Allen R, Carlsten C, Stieb D, Noonan C, Smargiassi A, Kaufman JD, Hajat S, Kosatsky T, Brauer M (2011) From good intentions to proven interventions: effectiveness of actions to reduce the health impacts of air pollution. Environ Health Perspect 119(1):29–36CrossRefGoogle Scholar
  38. Gilmore EA, Lave LB, Adams PJ (2006) The costs, air quality, and human health effects of meeting peak electricity demand with installed backup generators. Environ Sci Technol 40(22):6887–6893CrossRefGoogle Scholar
  39. Guarieiro ALN, Guarieiro LLN, Santos JVS and Andrade JB (2010) Particle number concentrations and size distributed mass emission factors for diesels and biodiesel engines. Poster presented at 2010 American Association of Aerosol Research International Specialty Conference on Air Pollution and Health, San DiegoGoogle Scholar
  40. Health Effects Institute (2010) Traffic-related air pollution: a critical review of the literature on emissions, exposure, and health effects. Special report 17. Health Effects Institute, Boston, MAGoogle Scholar
  41. Herner JD, Hu S, Robertson WH, Huai T, Collins JF, Dwyer H, Ayala A (2009) Effect of advanced aftertreatment for PM and NO(x) control on heavy-duty diesel truck emissions. Environ Sci Technol 43(15):5928–5933CrossRefGoogle Scholar
  42. Hesterberg TW, Bunn WB, McClellan RO, Hart GA, Lapin CA (2005) Carcinogenicity studies of diesel engine exhausts in laboratory animals: a review of past studies and a discussion of future research needs. Crit Rev Toxicol 35(5):379–411CrossRefGoogle Scholar
  43. Hexter CA, Goldsmith JR (1971) Carbon monoxide: association of community air pollution with mortality. Science 172:265–267CrossRefGoogle Scholar
  44. Hinners RG, Burkart JK, Contner GL (1966) Animal exposure chambers in air pollution studies. Arch Environ Health 13(5):609–615Google Scholar
  45. Hu S, Herner JD, Robertson W, Huai T, Collins J, Dwyer H and Ayala A (2011) Nucleation mode particle emissions from in-use heavy duty vehicles equipped with diesel particulate filter (DPF) and selective catalytic reduction (SCR) retrofits. Environ Sci Tech (in press)Google Scholar
  46. Hyde D, Orthoefer J, Dungworth D, Tyler W, Carter R, Lum H (1978) Morphometric and morphologic evaluation of pulmonary lesions in beagle dogs chronically exposed to high ambient levels of air pollutants. Lab Invest 38(4):455–469Google Scholar
  47. Hystad PU, Setton EM, Allen RW, Keller PC, Brauer M (2009) Modeling residential fine particulate matter infiltration for exposure assessment. J Expo Sci Environ Epidemiol 19(6):570–579CrossRefGoogle Scholar
  48. Karr CJ, Demers PA, Koehoorn MW, Lencar CC, Tamburic L, Brauer M (2009) Influence of ambient air pollutant sources on clinical encounters for infant bronchiolitis. Am J Respir Crit Care Med 180(10):995–1001CrossRefGoogle Scholar
  49. Katsouyanni K, Samet JM, Anderson HR, Atkinson R, Le Tertre A, Medina S, Samoli E, Touloumi G, Burnett RT, Krewski D, Ramsay T, Dominici F, Peng RD, Schwartz J, Zanobetti A (2009) Air pollution and health: a European and North American approach (APHENA). Res Rep Health Eff Inst 142:5–90Google Scholar
  50. Katsouyanni K, Schwartz J, Spix C, Touloumi G, Zmirou D, Zanobetti A, Wojtyniak B, Vonk JM, Tobias A, Ponka A, Medina S, Bacharova L, Anderson HR (1996) Short term effects of air pollution on health: a European approach using epidemiologic time series data: the APHEA protocol. J Epidemiol Community Health 50(Suppl 1):S12–S18CrossRefGoogle Scholar
  51. Kirchstetter TW, Agular J, Tonse S, Fairley D, Novakov T (2008) Black carbon concentrations and diesel vehicle emission factors derived from coefficient of haze measurements in California: 1967–2003. Atmos Environ 42(3):480–491CrossRefGoogle Scholar
  52. Kittelson DB (1998) Engines and nanoparticles: a review. J Aerosol Sci 29(5–6):575–588CrossRefGoogle Scholar
  53. Kittelson DB, Watts WF, Johnson JP (2004) Nanoparticle emissions on Minnesota highways. Atmos Environ 38(1):9–19CrossRefGoogle Scholar
  54. Kotin P, Falk HL, Thomas M (1954) Aromatic hydrocarbons. II. Presence in the particulate phase of gasoline-engine exhausts and the carcinogenicity of exhaust extracts. A M A Arch Ind Hyg Occup Med 9(2):164–177Google Scholar
  55. Kotin P, Falk HL, Thomas M (1955) Aromatic hydrocarbons. III. Presence in the particulate phase of diesel-engine exhausts and the carcinogenicity of exhaust extracts. AMA Arch Ind Health 11(2):113–120Google Scholar
  56. Laden F, Neas LM, Dockery DW, Schwartz J (2000) Association of fine particulate matter from different sources with daily mortality in six US cities. Environ Health Perspect 108(10):941–947CrossRefGoogle Scholar
  57. Lanni T, Frank BP, Tang S, Rosenblatt D and Lowell D (2003) Performance and emissions evaluation of compressed natural gas and clean diesel buses at New York City's Metropolitan Transit Authority, SAE Technical Paper 2003-01-0300. doi: 10.4271/2003-01-0300
  58. Lewis TR, Campbell KI, Vaughan TR Jr (1969) Effects on canine pulmonary function via induced NO2 impairment, particulate interaction, and subsequent SOx. Arch Environ Health 18(4):596–601Google Scholar
  59. Li W, Collins JF, Norbeck JM, Cocker DR and Sawant A (2006) Assessment of particulate matter emissions from a small fleet of in-use ULEV and SULEV vehicles. SAE Technical Paper 2006-01-1073. doi: 10.4271/2006-01-1076.
  60. Lippmann M, Ito K, Hwang JS, Maciejczyk P, Chen LC (2006) Cardiovascular effects of nickel in ambient air. Environ Health Perspect 114(11):1662–1669Google Scholar
  61. Madsen T, Davis B, Del Chiaro B (2010) Clean cars in California: four decades of progress in the unfinished battle to clean up our air. Environment California Research and Policy Center, California, USAGoogle Scholar
  62. Mauderly JL, Burnett RT, Castillejos M, Ozkaynak H, Samet JM, Stieb DM, Vedal S, Wyzga RE (2010) Is the air pollution health research community prepared to support a multipollutant air quality management framework? Inhal Toxicol 22(Suppl 1):1–19CrossRefGoogle Scholar
  63. Mauderly JL, Samet JM (2009) Is there evidence for synergy among air pollutants in causing health effects? Environ Health Perspect 117(1):1–6Google Scholar
  64. Mayer A, Czerwinski J, Petermann J, Wyzer M and Legerer F (2004) Reliability of DPF-systems: experience with 6000 applications of the Swiss Retrofit Fleet. SAE Technical Paper 2004-01-0076. doi: 10.4271/2004-01-0076.
  65. McCreanor J, Cullinan P, Nieuwenhuijsen MJ, Stewart-Evans J, Malliarou E, Jarup L, Harrington R, Svartengren M, Han IK, Ohman-Strickland P, Chung KF, Zhang J (2007) Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med 357(23):2348–2358CrossRefGoogle Scholar
  66. McDonald JD, Harrod KS, Seagrave J, Seilkop SK, Mauderly JL (2004) Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions. Environ Health Perspect 112(13):1307–1312CrossRefGoogle Scholar
  67. Michaels HM, Kupal J and Somers JH (2010) Mobile source emission reductions and CRC work. Coordinating Research Council 20th On-Road Vehicle Emissions Workshop, San Diego, CAGoogle Scholar
  68. Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, Newby DE (2007) Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 357(11):1075–1082CrossRefGoogle Scholar
  69. Mordukhovich I, Wilker E, Suh H, Wright R, Sparrow D, Vokonas PS, Schwartz J (2009) Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study. Environ Health Perspect 117(11):1767–1772Google Scholar
  70. Morgan G, Sheppeard V, Khalaj B, Ayyar A, Lincoln D, Jalaludin B, Beard J, Corbett S, Lumley T (2010) Effects of bushfire smoke on daily mortality and hospital admissions in Sydney, Australia. Epidemiology 21(1):47–55CrossRefGoogle Scholar
  71. National Research Council (1998) Research priorities for airborne particulate matter: I. immediate priorities and a long-range research portfolio. National Academies Press, Washington, D.CGoogle Scholar
  72. National Research Council (2004a) Air quality management in the United States. NRC, Washington, DCGoogle Scholar
  73. National Research Council (2004b) Research priorities for airborne particulate matter: IV. continuing research progress. National Academies Press, Washington, D.CGoogle Scholar
  74. Nethery E, Leckie SE, Teschke K, Brauer M (2008) From measures to models: an evaluation of air pollution exposure assessment for epidemiological studies of pregnant women. Occup Environ Med 65(9):579–586CrossRefGoogle Scholar
  75. Ostro B, Roth L, Malig B, Marty M (2009) The effects of fine particle components on respiratory hospital admissions in children. Environ Health Perspect 117(3):475–480CrossRefGoogle Scholar
  76. Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD (2008) Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116(7):937–942CrossRefGoogle Scholar
  77. Perez L, Kunzli N, Avol E, Hricko AM, Lurmann F, Nicholas E, Gilliland F, Peters J, McConnell R (2009) Global goods movement and the local burden of childhood asthma in southern California. Am J Public Health 99(Suppl 3):S622–S628CrossRefGoogle Scholar
  78. Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H (2004) Exposure to traffic and the onset of myocardial infarction. N Engl J Med 351(17):1721–1730CrossRefGoogle Scholar
  79. Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong H Jr, Thomas D (1999) A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med 159:760–767Google Scholar
  80. Pope CA 3rd (1996) Particulate pollution and health: a review of the Utah valley experience. J Expo Anal Environ Epidemiol 6(1):23–34Google Scholar
  81. Pope CA 3rd, Ezzati M, Dockery DW (2009) Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360(4):376–386CrossRefGoogle Scholar
  82. Pope CA III (1989) Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am J Public Health 79:623–628CrossRefGoogle Scholar
  83. Salem H, Cullumbine H (1961) Kerosene smoke and atmospheric pollutants. Arch Environ Health 2:641–647Google Scholar
  84. Samet JM, Buist S, Bascom R, Garcia J, Lipsett M, Mauderly JL, Manning D, Rand CS, Romieu I, Utell M, Wagner GR (2000a) What constitutes an adverse health effect of air pollution? Am J Respir Crit Care Med 161(2):665–673Google Scholar
  85. Samet JM, Jaakkola JJK (1999) The epidemiologic approach to investigating outdoor air pollution. In: Samet JM, Jaakkola JJK, Holgate ST, Koren HS, Maynard RL (eds) Air pollution and health. Academic, San Diego, pp 431–460CrossRefGoogle Scholar
  86. Samet JM, Zeger S, Dominici F, Dockery D, Schwartz J (2000b) The National Morbidity, Mortality, and Air Pollution Study (NMMAPS). Part I. Methods and methodological issues. Res Rep Health Eff Ins 94:5–14Google Scholar
  87. Schenker MB, Vedal S, Baatterman S, Samet JM, Speizer FE (1986) Health effects of air pollution due to coal combustion in the Chestnut Ridge region of Pennsylvania: cross-section survey of children. Arch Environ Heal 41(2):104–108CrossRefGoogle Scholar
  88. Seagrave J, McDonald JD, Gigliotti AP, Nikula KJ, Seilkop SK, Gurevich M, Mauderly JL (2002) Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions. Toxicol Sci 70(2):212–226CrossRefGoogle Scholar
  89. Setton E, Marshall JD, Brauer M, Lundquist KR, Hystad P, Keller P, Cloutier-Fisher D (2010) The impact of daily mobility on exposure to traffic-related air pollution and health effect estimates. J Expo Sci Environ Epidemiol 21(1):42–48CrossRefGoogle Scholar
  90. Somers JH, Michaels HM and Koupla JW (2010) Mobile source emission reductions and CRC work. Proceedings of the 20th Coordinating Research Council’s On-road Vehicle Emissions Workshop, San DiegoGoogle Scholar
  91. Speizer FE (1989) Studies of acid aerosols in six cities and in a new multi-city investigation: design issues. Environ Heal Perspect 79:61–67CrossRefGoogle Scholar
  92. Sperling D, Gordon D (2009) Two billion cars: driving toward sustainability. Oxford University Press, Oxford; New YorkGoogle Scholar
  93. Sultan ZM (2007) Estimates of associated outdoor particulate matter health risk and costs reductions from alternative building, ventilation and filtration scenarios. Sci Total Environ 377(1):1–11CrossRefGoogle Scholar
  94. Swann HE Jr, Balchum OJ (1966) Biological effects of urban air pollution. IV. Effects of acute smog episodes on respiration of guinea pigs. Arch Environ Health 12(6):698–704Google Scholar
  95. Tata Motors (2011) Tata 'NANO'—the people's car from Tata motors. Available via http://tatanano.inservices.tatamotors.com/tatamotors/. Accessed 28 Jan 2011
  96. The White House and Office of the Press Secretary (2010) President Obama directs administration to create first-ever national efficiency and emissions standards for medium- and heavy-duty trucks. Available via http://www.whitehouse.gov/the-press-office/president-obama-directs-administration-create-first-ever-national-efficiency-and-em. Accessed 21 May 2010.
  97. Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Hopke PK (2005) Workgroup report: workshop on source apportionment of particulate matter health effects—intercomparison of results and implications. Environ Health Perspect 113(12):1768–1774CrossRefGoogle Scholar
  98. Tonne C, Beevers S, Armstrong B, Kelly F, Wilkinson P (2008) Air pollution and mortality benefits of the London Congestion Charge: spatial and socioeconomic inequalities. Occup Environ Med 65(9):620–627CrossRefGoogle Scholar
  99. US Department of Energy, Chief Research Officers of the National Laboratories (2009) Transforming America’s energy economy, Report for the National Laboratory Directors CouncilGoogle Scholar
  100. US Environmental Protection Agency (2002) Health assessment document for diesel engine exhaust (final 2002). US EPA, Office of Research and Development, National Center for Environmental Assessment, Washington, DCGoogle Scholar
  101. US Environmental Protection Agency (2008) Analysis of particulate matter emissions from light-duty gasoline vehicles in Kansas City. Washington, DC, US EPAGoogle Scholar
  102. US Environmental Protection Agency (2009) Integrated science assessment for particulate matter (final report). US Environmental Protection Agency, Washington, DCGoogle Scholar
  103. US Environmental Protection Agency (2010a) Policy assessment for the review of the particulate matter national ambient air quality standards (second external review draft). US Environmental Protection Agency, Washington DCGoogle Scholar
  104. US Environmental Protection Agency (2010b) Quantitative health risk assessment for particulate matter (final report). US Environmental Protection Agency, Washington, DCGoogle Scholar
  105. van Donkelaar A, Martin RV, Brauer M, Kahn R, Levy R, Verduzco C, Villeneuve PJ (2010) Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application. Environ Health Perspect 118(6):847–855CrossRefGoogle Scholar
  106. Vaughan TR Jr, Jennelle LF, Lewis TR (1969) Long-term exposure to low levels of air pollutants. Effects on pulmonary function in the beagle. Arch Environ Health 19(1):45–50Google Scholar
  107. Vingarzan R (2004) A review of surface ozone background levels and trends. Atmos Environ 38(21):3431–3442CrossRefGoogle Scholar
  108. Winer AM and Paulson S (2010) Investigation and characterization of air pollution concentrations and gradients in port-adjacent communities and west and downtown Los Angeles using a mobile platform. Final Report, California Air Resources Board, Contract 04–348Google Scholar
  109. Yu CL, Wang SF, Pan PC, Wu MT, Ho CK, Smith TJ, Li Y, Pothier L, Christiani DC (2006) Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure. Am J Epidemiol 164(3):200–207CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Alberto Ayala
    • 1
  • Michael Brauer
    • 2
  • Joe L. Mauderly
    • 3
  • Jonathan M. Samet
    • 4
  1. 1.Monitoring and Laboratory Division, Cal/EPA–Air Resources BoardSacramentoUSA
  2. 2.School of Population and Public HealthThe University of British ColumbiaVancouverCanada
  3. 3.Lovelace Respiratory Research InstituteAlbuquerqueUSA
  4. 4.Department of Preventive Medicine, Keck School of Medicine of USC, USC Institute for Global HealthUniversity of Southern CaliforniaLos AngelesUSA

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