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Use of Immune Checkpoint Inhibitors in Mesothelioma

  • Patrick M. Forde
  • Arnaud Scherpereel
  • Anne S. TsaoEmail author
Lung Cancer (HA Wakelee, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Lung Cancer

Opinion statement

Recent advances in immunology have extended into the mesothelioma field. To date, only Japan has given regulatory approval to salvage nivolumab in chemo-refractory mesothelioma patients. The USA has included in the NCCN guidelines that pembrolizumab (in programmed death ligand 1 (PD-L1) immunohistochemistry (IHC)–positive patients) and nivolumab with or without ipilimumab (whatever the PD-L1 status is) are accepted salvage therapies. Based on the growing body of literature, it is anticipated that checkpoint inhibitors will receive regulatory approval in the USA and Europe soon for salvage therapy. Additional research efforts will determine whether earlier stage patients and frontline unresectable patients will benefit from the addition of immunotherapy to their treatment regimens. The realm of biomarker research has lagged behind in mesothelioma. In general, mesothelioma has less tumor mutation burden than other malignancies. Most of the single-agent salvage checkpoint inhibitor trials have shown a trend correlating higher PD-L1 immunohistochemistry (IHC) with responses. However, survival data remains immature and a larger number of patient outcomes are needed to ascertain the value of PD-L1 IHC as a predictive biomarker. Incorporation of translational studies in all immunotherapy trials and especially window-of-opportunity resectable studies should be supported and instituted in all future mesothelioma trials.

Keywords

Mesothelioma Immunotherapy Checkpoint inhibitors 

Notes

Compliance with Ethical Standards

Conflict of Interest

Patrick M. Forde has received a research funding from AstraZeneca, Bristol-Myers Squibb, Corvus, Kyowa Kirin, and Novartis and has received compensation from AbbVie, Astra Zeneca, Bristol-Myers Squibb, Boehringer Ingelheim, EMD Serono, Inivata, Eli Lilly, Merck, and Novartis for the service on advisory boards and/or as a consultant.

Arnaud Scherpereel has received a research funding (paid to his institution) from Bristol-Myers Squibb and MSD; has received a compensation from AstraZeneca, Bristol-Myers Squibb, MSD, and Roche for participation on advisory boards and/or lectures provided; and has received a travel support to international meetings on thoracic oncology from Bristol-Myers Squibb, MSD, and Roche.

Anne S. Tsao has received a research funding from Bristol-Myers Squibb, Genentech/Roche, Eli Lilly, Millennium, Seattle Genetics, Ariad, Boehringer Ingelheim, Polaris, Epizyme, Merck, AstraZeneca, and Takeda and has received compensation from Bristol-Myers Squibb, Genentech/Roche, Ariad, Boehringer Ingelheim, AstraZeneca, and Takeda for the participation on advisory boards.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Patrick M. Forde
    • 1
  • Arnaud Scherpereel
    • 2
    • 3
  • Anne S. Tsao
    • 4
    Email author
  1. 1.Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins UniversityBaltimoreUSA
  2. 2.Pulmonary and Thoracic Oncology DepartmentUniv Lille, CHU Lille, INSERM U1189 OncoThAILilleFrance
  3. 3.French National Network of Clinical Expert Centers for Malignant Pleural Mesothelioma Management (MESOCLIN)LilleFrance
  4. 4.Department of Thoracic/Head and Neck Medical OncologyUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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