Minimal Residual Disease in Indolent Lymphomas: A Critical Assessment

  • Daniele Grimaldi
  • Elisa Genuardi
  • Martina Ferrante
  • Simone Ferrero
  • Marco LadettoEmail author
Lymphoma (DO Persky, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Lymphoma

Opinion statement

Indolent non-Hodgkin lymphomas (iNHL) are a heterogeneous group of pathologies characterized by a prolonged natural history and good response to treatment. They also have a tendency to relapse, in some cases with a worse prognosis. One of the main objectives in the newest clinical trials is to identify patients at high risk of relapse. This cannot be accomplished using only clinical prognostic scores. Detection of minimal residual disease (MRD) is effective in evaluating long-term disease response, with a strong and independent predictive value that was demonstrated in large cohorts of patients. Analysis of MRD allows patient stratification based on the risk for relapse; therefore, different therapeutic programs can be designed based on the response characteristics. This tailored therapy is already happening in current clinical trials. Limits imposed by traditional PCR-based tools are being overcome due to new molecular biology techniques like droplet digital PCR and next generation sequencing. Although these techniques are not yet standardized, they will likely increase the reliability and ensure broad applicability of MRD detection in future years.


FL MRD Predictive value ddPCR NGS 


Compliance with Ethical Standards

Conflict of Interest

Daniele Grimaldi declares that he has no conflict of interest.

Elisa Genuardi declares that she has no conflict of interest.

Martina Ferrante declares that she has no conflict of interest.

Simone Ferrero has received compensation from Janssen for service as a consultant; compensation from Janssen and Pfizer for participation on advisory boards; and compensation from Janssen, Pfizer, and Gilead for service on speakers’ bureaus.

Marco Ladetto declares, in the past 5 years, the following relationships in terms of consultancy, participation on advisory boards, invitations to scientific meetings, institutional research support, and contracts: AbbVie, Acerta, Amgen, Archigen, Celgene, ADC Therapeutics, Gilead, Novartis, Johnson & Johnson, Roche, Roche Diagnostics, Sandoz, and Takeda.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Daniele Grimaldi
    • 1
  • Elisa Genuardi
    • 1
  • Martina Ferrante
    • 1
  • Simone Ferrero
    • 1
    • 2
  • Marco Ladetto
    • 3
    Email author
  1. 1.Department of Molecular Biotechnologies and Health Sciences - Hematology DivisionUniversity of TurinTurinItaly
  2. 2.Hematology DivisionA.O.U. “City of Health and Science of Turin”TurinItaly
  3. 3.A.O. SS Antonio e Biagio and Cesare ArrigoAlessandriaItaly

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