The Role of PD-1 Checkpoint Inhibition in Gynecologic Malignancies

  • Christine Garcia
  • Kari L. RingEmail author
Gynecologic Cancers (LA Cantrell, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gynecologic Cancers

Opinion statement

Activity of PD-1 and PD-L1 inhibitors has been demonstrated in ovarian, endometrial, and cervical cancer, with a tolerable side effect profile and the highest response rate seen in mismatch repair–deficient endometrial cancers. Other biomarkers are under active investigation. Tumor testing for mismatch repair deficiency or high microsatellite instability for treatment with pembrolizumab should be considered an option for all women with progressive gynecologic malignancy.


Programmed death ligand-1 Immunotherapy Gynecologic cancer Ovarian cancer Endometrial cancer Cervical cancer 


Compliance with Ethical Standards

Conflict of Interest

The authors declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Thorton Division of Gynecologic Oncology, Department of Obstetrics and GynecologyUniversity of VirginiaCharlottesvilleUSA

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