Review of Immune Therapies Targeting Ovarian Cancer
The rise of immunotherapy is the greatest advance in oncology to occur over the last several years, but applications in gynecologic malignancies lag behind other tumors. The term “immunotherapy” envelops monoclonal antibodies as receptor mediators, including immune checkpoint inhibitors (ICPI), cancer vaccines, and adoptive immunotherapies alone or in combination with other therapeutic approaches. The purpose of this review is to summarize the status of immunotherapy trials in ovarian cancer and to specifically highlight data published in the last 1–2 years.
KeywordsOvarian cancer Immunotherapy Immune checkpoint inhibitors Cancer vaccine Adoptive immunotherapy PD1 PD-L1 PD-L2 CTLA-4 Nivolumab Ipilimumab Pembrolizumab Avelumab Atezolizumab PARP inhibitors BRCA 1/2 mutation Microsatellite instability Bevacizumab Anti-angiogenic NY-ESO MAGE p53 Mirvetuximab soravtansine Folate receptor alpha Folate-binding protein TILS CAR-T cells NK cells T cells HER2 Mesothelin
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
References and Recommended Reading
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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