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Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?

  • Ravin Ratan
  • Shreyaskumar R. Patel
Sarcoma (SH Okuno, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Sarcoma

Opinion Statement

Trabectedin and eribulin are two agents that have been recently approved for the treatment of specific soft tissue sarcoma subtypes. They have proved to be a much-needed line of additional treatment for patients with these rare tumors, but their activity remains admittedly modest in most cases. Further exploitation of these novel agents is likely to require a more granular understanding of the salient mechanisms of action. For example, if as some studies suggest, eribulin derives its benefit from restructuring of tumor vasculature to improve efficacy of subsequent lines of therapy, then patients may benefit from its use earlier in the treatment pathway. The sequencing of trabectedin with other agents is also worth examining. In a disease like myxoid liposarcoma, consideration should be given to using trabectedin before other salvage regimens like gemcitabine and docetaxel, given its tolerability and excellent efficacy against this sarcoma subtype. Also, to be further investigated is the use of trabectedin in sarcoma subtypes which were excluded from the phase III study, but in which activity has been documented in earlier trials and subsequent reports. Combinations of trabectedin with other agents, particularly doxorubicin, have been explored, but the data to date do not support the routine use of these regimens.

Keywords

Soft tissue sarcoma Trabectedin Eribulin Liposarcoma Leiomyosarcoma 

Notes

Compliance with Ethical Standards

Conflict of Interest

Ravin Ratan declares that he has no conflict of interest.

Shreyaskumar R. Patel has received compensation from Janssen, Eisai, EMD-Serono, CytRx, Bayer, and Eli Lilly for service as a consultant, and financial support through grants from Janssen, Eisai, and Morphotek.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Sarcoma Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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