Current Treatment Options in Oncology

, Volume 15, Issue 2, pp 171–186 | Cite as

Optimal Therapy for Adult Patients with Acute Myeloid Leukemia in First Complete Remission

Leukemia (JP Dutcher, Section Editor)
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Opinion statement

Although it is absolutely clear that postremission therapy is currently necessary to obtain disease-free long-term survivorship for patients with acute myeloid leukemia (AML) in first complete remission (CR), it is not entirely clear what form that treatment should take. High-dose cytarabine is clearly effective and there definitely is a dose-response relationship for cytarabine and remission duration. High-dose cytarabine is effective for younger patients but not elderly patients. It is effective for patients with favorable cytogenetics but it is not clear whether it is effective for patients with intermediate or unfavorable cytogenetics. Furthermore, it is not clear what the most effective and least toxic dose and schedule of high-dose cytarabine is.

Keywords

Acute myeloid leukemia High-dose cytarabine Cytogenetics Lenalidomide Clofarabine Interleukin-2 Stem cell transplantation 

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Cancer Research Foundation of New YorkChappaquaUSA

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