Advances and Future Directions in the Targeting of HER2-positive Breast Cancer: Implications for the Future
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The natural history of HER2-positive breast cancer significantly changed in the past 15 years. Form being the most aggressive type of breast cancer, it became treatable with important cure rates. However, with new and successful drugs, resistance emerges. Progress in research and drug development continues to make available effective anti-HER2 therapies. Our challenge today is to use these tools correctly by looking at the data that support the indications of each compound and to continue clinical trial participation.
KeywordsHER2-positive breast cancer Trastuzumab resistance Pertuzumab T-DM1 PI3K signaling Immunotherapy
Conflict of Interest
Ishwaria M. Subbiah declares no conflict of interest.
Ana Maria Gonzalez-Angulo has research funding and paid consultancy to Genentech, Novartis and GlaxoSmithKline.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
This work was supported in part by National Cancer Institute 1K23CA121994 (AMG) ASCO Career Development Award (AMG), Komen for the Cure Catalystic Award KG090341 (AMG), American Cancer Society Research Scholar Grant 121329-RSG-11-187-01-TBG (AMG), National Cancer Institute through The University of Texas MD Anderson’s Cancer Center Support Grant (P30 CA016672).
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