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Current Treatment Options in Oncology

, Volume 10, Issue 1–2, pp 94–106 | Cite as

The Clinical Management of Chondrosarcoma

  • Richard F. RiedelEmail author
  • Nicole Larrier
  • Leslie Dodd
  • David Kirsch
  • Salutario Martinez
  • Brian E. Brigman
Bone Cancer

Opinion statement

Chondrosarcomas (CHS) represent a heterogeneous group of disorders ranging from indolent, low-grade tumors to aggressive, high-grade forms. Surgical resection represents the primary and preferred treatment modality for individuals with localized disease. Radiation therapy is appropriate for the treatment of positive surgical margins or palliation of disease-related symptoms. The treatment of advanced, metastatic disease is particularly challenging given the recognition that conventional chemotherapy has proven to be largely ineffective. Systemic chemotherapy may be considered in variant forms such as mesenchymal or dedifferentiated chondrosarcomas but high-quality data supporting its use is limited. There is universal agreement, however, that novel treatment strategies are desperately needed. This review will highlight the need for a coordinated multidisciplinary approach to optimize the management and care of patients.

Keywords

Standard Uptake Value National Comprehensive Cancer Network Radiat Oncol Biol Phys Chondrosarcoma National Comprehensive Cancer Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CGE

Cobalt gray equivalent

CHS

Chondrosarcoma(s)

CT

Computed tomography

DFS

Disease free survival

FDG

Fluorodeoxyglucose

FSRT

Fractionated stereotactic radiation therapy

GE

Gray equivalent

GY

Gray

HE

Helium

MR

Magnetic resonance

MRI

Magnetic resonance imaging

NCCN

National comprehensive cancer network

NE

Neon

PET

Positron emission tomography

RT

Radiation therapy

SUV

Standard uptake value

TRAIL

TNF-related apoptosis inducing ligand

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References and Recommended Reading

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Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  • Richard F. Riedel
    • 1
    Email author
  • Nicole Larrier
    • 2
  • Leslie Dodd
    • 3
  • David Kirsch
    • 2
  • Salutario Martinez
    • 4
  • Brian E. Brigman
    • 5
  1. 1.Division of Medical Oncology, Department of Internal MedicineDuke University Medical CenterDurhamUSA
  2. 2.Department of Radiation OncologyDuke University Medical CenterDurhamUSA
  3. 3.Department of PathologyDuke University Medical CenterDurhamUSA
  4. 4.Department of RadiologyDuke University Medical CenterDurhamUSA
  5. 5.Division of Orthopaedic Surgery, Department of SurgeryDuke University Medical CenterDurhamUSA

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