Current Treatment Options in Oncology

, Volume 8, Issue 4, pp 287–295 | Cite as

Mutational Analysis and Overcoming Imatinib Resistance in Chronic Myeloid Leukemia with Novel Tyrosine Kinase Inhibitors

Acute Leukemia

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References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: *Of importance **Of major importance

  1. 1.
    Peng B, Hayes M, Resta D, et al.: Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004; 22(5):935–942PubMedCrossRefGoogle Scholar
  2. 2.
    Druker BJ, Talpaz M, Resta DJ, et al.: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344(14):1031–1037PubMedCrossRefGoogle Scholar
  3. 3.**
    Druker BJ, Guilhot F, O’Brien SG, et al.: Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355:2408–2417PubMedCrossRefGoogle Scholar
  4. 4.
    Kantarjian H, Talpaz M, O’Brien S, et al.: High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004; 103(8):2873–2878PubMedCrossRefGoogle Scholar
  5. 5.
    Druker BJ, Kantarjian HM, Talpaz M, et al.: A Phase I study of Gleevec (Imatinib Mesylate) administered concomitantly with cytosine arabinoside (Ara-C) in patients with Philadelphia positive chronic myeloid leukemia (CML). Blood 2001; 98:845aGoogle Scholar
  6. 6.
    O’Dwyer ME, Mauro MJ, Kuyl J, et al.: Preliminary evaluation of the combination of Imatinib mesylate (Gleevec) in combination with low dose Interferon-alpha for the treatment of chronic phase CML. Blood 2001; 98(11):846aGoogle Scholar
  7. 7.
    Mauro MJ, O’Dwyer ME, Stone RM, et al.: Preliminary evaluation of the combination of imatinib mesylate (Gleevec) with low dose Ara-C as initial therapy for newly diagnosed chronic phase CML. Blood 2002; 100(11):165aGoogle Scholar
  8. 8.
    Gardembas M, Rousselot P, Tulliez M, et al.: Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase. Blood 2003; 102(13):4298–4305PubMedCrossRefGoogle Scholar
  9. 9.
    Gorre ME, Mohammed M, Ellwood K, et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293:876–888PubMedCrossRefGoogle Scholar
  10. 10.
    Hughes T, Deininger M, Hochhaus A, et al.: Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28–37PubMedCrossRefGoogle Scholar
  11. 11.
    Deininger M, Buchdunger E, Druker BJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640–2653PubMedCrossRefGoogle Scholar
  12. 12.
    Schindler T, Bornmann W, Pellicena P, et al.: Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 2000; 289(5486):1938–1942PubMedCrossRefGoogle Scholar
  13. 13.
    Hochhaus A, Kreil S, Corbin AS, et al.: Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16:2190–2196PubMedCrossRefGoogle Scholar
  14. 14.
    Donato NJ, Wu JY, Stapley J, et al.: BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101:690–698PubMedCrossRefGoogle Scholar
  15. 15.*
    Deborah L, White DL, Verity A, et al.: OCT-1–mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108(2):697–704CrossRefGoogle Scholar
  16. 16.
    Willis SG, Lange T, Demehri S, et al.: High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005;106:2128–2137PubMedCrossRefGoogle Scholar
  17. 17.
    National Comprehensive Cancer Network Chronic Myelogenous Leukemia Clinical Practice Guidelines in Oncology, v.2.2008. http://www.nccn.org/professionals/physician_gls/PDF/cml.pdf. Accessed August 1, 2007
  18. 18.**
    Baccarani M, Saglio G, Goldman J, et al.: Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemia net. Blood 2006; 108(6):1809–1820PubMedCrossRefGoogle Scholar
  19. 19.*
    Talpaz M, Shah NP, Kantarjian H, et al.: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354:2531–2541PubMedCrossRefGoogle Scholar
  20. 20.*
    Kantarjian H, Giles F, Wunderle L, et al.: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542–2551PubMedCrossRefGoogle Scholar
  21. 21.
    Baccarani HM, Kantarjian H, Apperley JF, et al.: Efficacy of dasatinib (Sprycel) in patients with chronic phase chronic myeloid leukemia (CP-CML) resistant or intolerant to imatinib: updated results of the CA180013 ‘START-C’ phase II study. Blood (ASH Annual Meeting Abstracts) 2006; 108:164aGoogle Scholar
  22. 22.**
    Hochhaus A, Kantarjian HM, Baccarani M, et al.: Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109:2303–2309PubMedCrossRefGoogle Scholar
  23. 23.
    Guilhot F, Apperley J, Facon T, et al.: Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: updated results of the CA180013 (START-C) trial. European Hematology Association Proceedings 2007, Abstract #358Google Scholar
  24. 24.
    Rosti G, le Coutre P, Bhalla K, et al.: A phase II study of nilotinib administered to imatinib resistant and intolerant patients with chronic myelogenous leukemia (CML) in chronic phase (CP). ASCO 2007, #7007 (Abstract)Google Scholar
  25. 25.**
    Kantarjian HM, Giles F, Gattermann N, et al.: Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007, 110(10):3540–3546Google Scholar
  26. 26.**
    Kantarjian H, Pasquini R, Hamerschlak N, et al.: Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood 2007; 109(12):5143–5150PubMedCrossRefGoogle Scholar
  27. 27.
    Hochhaus A, Kim DW, Rousselot P, et al.: Dasatinib (SPRYCEL) 50 mg or 70 mg BID versus 100 mg or 140 mg QD in patients with chronic myeloid leukemia in chronic phase (CML-CP) resistant or intolerant to imatinib: results of the CA180-034 study. Blood (ASH Annual Meeting Abstracts) 2006; 108:166Google Scholar
  28. 28.
    Giles F, Cortes J, Bergstrom DA, et al.: MK-0457, a novel aurora kinase and BCR-ABL inhibitor, is active against BCR-ABL T315I mutant chronic myelogenous leukemia (CML). Blood (ASH Annual Meeting Abstracts) 2006; 108:163Google Scholar
  29. 29.
    Cortes J, Kantarjian H, Baccarani M, et al.: A Phase 1/2 Study of SKI-606, a dual inhibitor of Src and Abl kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory or intolerant of imatinib. Blood (ASH Annual Meeting Abstracts) 2006; 108:168Google Scholar
  30. 30.
    Yokota A, Kimura S, Masuda S, et al.: INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity. Blood 2007; 109(1):306–314PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc. 2007

Authors and Affiliations

  1. 1.Center for Hematologic MalignanciesOregon Health & Science UniversityPortlandUSA

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